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Lovastatin

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Definition: A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.     
Pharmacological Action Anticholesteremic Agents; Hydroxymethylglutaryl-CoA Reductase Inhibitors
Examples Simvastatin 		Other names Mevinolin; Lovastatin, 1 alpha-Isomer; alpha-Isomer Lovastatin, 1; MK803; MK 803; Lovastatin, 1 alpha Isomer; 6 Methylcompactin; 1 alpha-Isomer Lovastatin; Monacolin K; Mevacor; MK-803; Lovastatin, (1 alpha(S*))-Isomer; 6-MethylcompactinDrugs* : LOVASTATIN; MEVACOR; ALTOPREV
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
lovastatin-niacin combination  0   *Lovastatin *Niacin Drug Combinations. J Clin Hypertens (Greenwich) 2002 Mar-Apr;4(2):146-7ADVICOR
dihydroxy-7-(1,2,3,5,6,7,8,8a-octahydro-3,5-dihydroxy-2,6-dimethyl-8-(2-methylbutyryloxy)naphthalen-1-yl)heptanoic acid lactone  0   Lovastatin/*analogs & derivatives. J Antibiot (Tokyo) 1997 Sep;50(9):750-4
dihydroxy-7-(1,2-dihydro-2-hydroxymethyl-6-methylnaphthalen-1-yl)heptanoic acid  0   Lovastatin/*analogs & derivatives. J Antibiot (Tokyo) 1997 Sep;50(9):750-4
6-(2-(8-((4-fluorobenzyl)oxy)-1,2,6,7,8,8a-hexahydro-2,6-dimethyl-1-naphthyl)ethyl)-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one  79691-18-2   Lovastatin/*analogs & derivatives Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Med Chem 1991;34(8):2474
L 669262  130468-11-0 Butanoic acid, 2,2-dimethyl-, 1,2,6,7,8,8a-hexahydro-3,7-dimethyl-6-oxo-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha,7beta,8beta(2S*,4S*),8abeta))  Lovastatin/*analogs & derivatives Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Antibiot (Tokyo) 1991;44(3):366
L 647318  87770-13-6 Butanoic acid, 2,2-dimethyl-, decahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha,3alpha,4aalpha,7beta,8beta(2S*,4S*),8abeta))  Lovastatin/*analogs & derivatives Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Pharm Res 1990;7(3):289
L 157012  114801-27-3 Butanoic acid, 2,2-dimethyl-, 1,2,3,7,8,8a-hexahydro-3-(hydroxymethyl)-7-methyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha,3beta,7beta,8beta(2S*,4S*),8abeta))  Lovastatin/*analogs & derivatives Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Pharm Res 1990;7(3):289
mevinolinic acid  77285-87-1   Lovastatin/*analogs & derivatives Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Teratology 1983;28(3):449
6-hydroxyisocompactin  85798-96-5 Butanoic acid, 2-methyl-, 1,2,6,7,8,8a-hexahydro-6-hydroxy-7-methyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester  Lovastatin/*analogs & derivatives Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Antibiot (Tokyo) 1983;36(7):918
dihydrocompactin  78366-44-6 Butanoic acid, 2-methyl-, 1,2,3,4,4a,7,8,8a-octahydro-7-methyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),4aalpha,7beta,8beta(2S*,4S*),8abeta))  Lovastatin/*analogs & derivatives Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Antibiot (Tokyo) 1981;34(5):614
dihydromevinolin  77517-29-4 Butanoic acid, 2-methyl-, 1,2,3,4,4a,7,8,8a-octahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,4aalpha,7beta,8beta(2S*,4S*),8abeta))  Lovastatin/*analogs & derivatives Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. J Antibiot (Tokyo) 1981;34(5):507
compactin  73573-88-3 7-(1,2,6,7,8,8a-hexahydro-2-methyl-8- (2-methylbutyryloxy)naphthyl)-3-hydroxyheptan-5-olide  Lovastatin/*analogs & derivatives.
Pharma Action Anti-Bacterial Agents ; Anticholesteremic Agents ; Antifungal Agents ; Hydroxymethylglutaryl-CoA Reductase Inhibitors 		Atherosclerosis 1980;35(3):259; Biochim Biophys Acta 1979;575(2):266; Biochim Biophys Acta 489(1):120;1977; Eur J Biochem 77:31;1977; Eur J Biochem 87(2):313;1978; J Antibiotics 29(12):1346;1976; J Biol Chem 1980;255(8):3715; J Biol Chem 253(4):1121;1978; J Chem Soc Perkin I 11:1165;1976; Jpn J Med Sci Biol 31(3):225;1978; Lancet 2(8104/5):1342;1978; Proc Natl Acad Sci USA 1979;76(11):5709

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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