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Lyases

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Definition: A class of enzymes that catalyze the cleavage of C-C, C-O, and C-N, and other bonds by other means than by hydrolysis or oxidation. (Enzyme Nomenclature, 1992) EC 4.     
Examples Carbon-Carbon Lyases; Carbon-Nitrogen Lyases; Carbon-Oxygen Lyases; Carbon-Sulfur Lyases; Ferrochelatase; Phosphorus-Oxygen Lyases 		Other names Desmolases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
GUN5 protein, Arabidopsis  EC 4.99.1.-   *Lyases *Arabidopsis Proteins Membrane Proteins Protein Subunits. Plant Cell 2011 Apr;23(4):1449-67
indolyl-3-acetaldoxime dehydratase, Sclerotinia sclerotiorum  EC 4.99.1.6   *Lyases. Phytochemistry. 2010 Dec;71(17-18):1952-62
homocysteine alpha,gamma-lyase  EC 4.-   *Lyases Recombinant Proteins. Clin Chem 2002 Sep;48(9):1560-4
glutamine - phenylpyruvate transaminase  EC 2.6.1.64   *Transaminases *Lyases. J Biol Chem 1986 Nov 25;261(33):15529-37
oxd protein, Bacillus  EC 4.99.-   *Lyases *Bacterial Proteins. Biochemistry. 2000 Feb 1;39(4):800-9.; Biosci Biotechnol Biochem. 2001 Dec;65(12):2666-72.; Protein Expr Purif. 2003 Mar;28(1):131-9.
NblB protein, Synechococcus sp.  EC 4.4.-   *Bacterial Proteins *Lyases. J Bacteriol 1999 Jan;181(2):610-7
PhnI protein, Rhizobium meliloti  EC 4.99.-   *Bacterial Proteins *Lyases Bacterial Proteins. J Bacteriol 1999 Jan;181(2):389-95
TftG protein, Burkholderia cepacia  EC 4.5.1.-   *Bacterial Proteins *Lyases. J Bacteriol 1998 Sep;180(17):4667-75
formate hydrogen lyase  EC 4.99.-   *Lyases. Biofizika 1996 Mar-Apr;41(2):369-76
ChlH protein, Synechocystis  EC 4.99.1.-   *Bacterial Proteins *Lyases. J Biol Chem 1996 Jul 12;271(28):16662-7
ChlD protein, Synechocystis sp. PCC 6803  EC 4.99.1.-   *Lyases *Bacterial Proteins. J Biol Chem 1996 Jul 12;271(28):16662-7
MerB protein, Bacteria  EC 4.99.1.2   *Bacterial Proteins *Lyases. Gene 1995 Dec 1;166(1):77-82
CYT2 protein, S cerevisiae  EC 4.99.-   *Lyases *Saccharomyces cerevisiae Proteins. J Biol Chem 1995 Sep 29;270(39):22842-9
phycoerythrocyanin alpha-subunit phycobiliviolin lyase protein, bacteria  EC 4.4.-   *Bacterial Proteins *Lyases. J Biol Chem 1995 May 26;270(21):12877-84
magnesium chelatase  EC 4.99.1-   *Lyases. Plant Physiol 1994 Feb;104(2):639-48
2-deoxy-scyllo-inosose synthase  EC 4.99.-   *Lyases. J Antibiot (Tokyo) 1993 Dec;46(12):1916-8
PabC protein, Bacteria  134548-61-1   *Bacterial Proteins *Lyases 4-Aminobenzoic Acid. Eur J Biochem 1993 Jan 15;211(1-2):373-6
phycocyanin alpha-subunit phycocyanobilin lyase  EC 4.4.-   *Lyases. Proc Natl Acad Sci U S A 1992 Aug 1;89(15):7017-21
ethylene-forming enzyme, Pseudomonas  EC 4.-   *Lyases. J Gen Microbiol 1991 Oct;137(Pt 10):2281
linA protein, Pseudomonas paucimobilis  EC 4.5.1.-   *Bacterial Proteins *Lyases. J Bacteriol 1991;173(21):5807
haloalcohol hydrogen-halide lyase  EC 4.5.1.-   *Lyases. J Bacteriol 1991;173(1):124
D-selenocystine alpha, beta-lyase  EC 4.99.-   *Lyases. J Bacteriol 1988;170(2):751
homocysteine desulfhydrase  EC 4.4.1.2   *Lyases. Exp Parasitol 1987;63(2):143
carbon-phosphorus lyase  EC 4.99.-   *Lyases. J Bacteriol 1987;169(2):710
alkylmercury lyase  EC 4.99.1.2   *Lyases. Biochemistry 1986;25(22):7186
dichloromethane dehalogenase  EC 4.5.-   *Lyases. J Bacteriol 1985;162(2):676
ethylene forming enzyme  EC 4.-   *Lyases. Biochem Biophys Res Commun 1982;105(1):271
selenocysteine lyase  EC 4.4.1.16   *Lyases. J Biol Chem 1982;257(8):4386
carbon-sulfur lyase  EC 4.4.-   *Lyases. Life Sci 1981;29(23):2399
cobaltochelatase  EC 4.99.1.-   *Lyases *Bacterial Proteins. Enzyme 1981;26(6):288
3-chloro-D-alanine dehydrochlorinase  EC 4.5.1.2   *Lyases. Biochem Biophys Res Commun 1981;100(3):1104
cytochrome C synthetase  EC 4.4.1.17   *Lyases. J Biol Chem 1981;256(16):8646
protein A24 lyase  EC 4.-   *Lyases. Biochemistry 1981;20(5):1100
homocysteine cystathionine gamma-synthase  EC 4.4.-   *Lyases. Biochem Med 9(1):90;1974
diacetyl methyl carbinol synthetase  EC 4.-   *Lyases. Biochim Biophys Acta 279(3):554;1972
sulphoacetaldehyde lyase  EC 4.4.1.12   *Lyases. J Biochem(Tokyo) 76(1):229;1974; J Biochem(Tokyo) 78(2):317;1975
S-sulfocysteine synthase  EC 4.-   *Lyases. Arch Microbiol 109(1-2):101;1976
squalene cyclase  EC 4.-   *Lyases. J Biol Chem 245(6):1247;1970
salicylate synthetase  EC 4.-   *Lyases. Biochim Biophys Acta 264(1):106;1972
mucopolysaccharidase  9031-30-5 Lyase, mucopolysaccharide  *Glucuronidase *Lyases. Arch Oral Biol 1980;24(10-11):735; J Biol Chem 240:3724;1965; J Dent Res 1980;59(5):766; J Urol Nephrol 82(7-8):695;1976; Josai Shika Daigaku Kiyo 6(1):117;1977; Jpn J Pharmacol 26:91;1976; Praxis 68(27):892;1979
1-aminocyclopropanecarboxylate synthase  EC 4.4.1.14 S-adenosylmethionine methylthioadenosine-lyase (alpha, gamma-eliminating)  *Lyases Lyases/antagonists & inhibitors Arabidopsis Proteins. Arch Biochem Biophys 198(1):280;1979
dehydrochlorinases  EC 4.5.-   *Lyases. J Environ Sci Health B13(1):25;1978
DDT-dehydrochlorinase  EC 4.5.1.1   *Lyases. Comp Biochem Physiol 44(2):441;1973; Pesticides 3:425;1975
cystathionine beta-lyase  EC 4.4.1.8   *Lyases.
gamma-cyanoaminobutyrate synthase  EC 4.-   *Lyases. Biochemistry 12(26):5369;1973; Int J Pept Protein Res 13(1):102;1979
beta-cyanoalanine synthase  EC 4.4.1.9   *Lyases. Anal Biochem 83:739;1977; Arch Biochem Biophys 190(2):553;1978; Biochimie 58(1-2):9;1976; Biokhimiia 43(9):1674;1978; Int J Biochem 1980;11(1):69; Proc Natl Acad Sci USA 72(4):1617;1975
cortisol lyase  EC 4.1.2.-   *Lyases. Endocrinology 95(1):38;1974

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