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Mannich Bases

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Definition: Ketonic amines prepared from the condensation of a ketone with formaldehyde and ammonia or a primary or secondary amine. A Mannich base can act as the equivalent of an alpha,beta unsaturated ketone in synthesis or can be reduced to form physiologically active amino alcohols.  IM general only    Other names Bases, Mannich
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Ydcm67 compound  0   *Mannich Bases 4-Aminobenzoic Acid/*analogs & derivatives Isocitrate Lyase/antagonists & inhibitors. Int J Biol Sci 2011;7(3):376-82
NC 1153  0   *Mannich Bases. Expert Opin Ther Targets 2004 Dec;8(6):613-29
NC 1175  0   *Mannich Bases *Piperidines. J Antimicrob Chemother 1998 Nov;42(5):585-90
1-ethyl-3-((4-methylphenyl)-1-oxo-2-propenyl)-4-((4-methylphenyl)ethenyl)piperidine  0   *Mannich Bases *Piperidines. J Med Chem 1998 Oct 8;41(21):4012-20
NC 758  125563-95-3 1-Penten-3-one, 1,1'-(1,4-phenylene)bis(5-(diethylamino))-4,4-dimethyl-, dihydrobromide, (E,E)  *Mannich Bases. Fundam Appl Toxicol 1990;14(2):318
1-(4-chlorophenyl)-4,4-dimethyl-5-diethylamino-1-penten-3-one  121229-92-3   *Chlorobenzenes *Ketones Mannich Bases Sulfhydryl Reagents. Anal Biochem 1989;177(2):237
4-dimethylaminomethyl-1-(3-hydroxyphenyl)-1-nonen-3-one  81134-44-3 1-Nonen-3-one, 4-((dimethylamino)methyl)-1-(3-hydroxyphenyl)-, (E)  *Mannich Bases. J Pharm Sci 1982;71(1):25
1-(3,4-dichlorophenyl)-4-((dimethylamino)methyl) 1-nonen-3-one  69489-30-1   *Mannich Bases. J Pharm Sci 69(11):1383;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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