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Mannitol

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Definition: A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.     
Pharmacological Action Diuretics, Osmotic; Sweetening Agents
Examples Mannitol Phosphates; Mitobronitol 		Other names Osmitrol; Osmofundin; (L)-MannitolDrugs* : OSMITROL 5% IN WATER; MANNITOL 20%; MANNITOL 10% W/ DEXTROSE 5% IN DISTILLED WATER; MANNITOL 15% IN PLASTIC CONTAINER; MANNITOL 25%; OSMITROL 15% IN WATER; MANNITOL 5% IN PLASTIC CONTAINER; OSMITROL 20% IN WATER IN PLASTIC CONTAINER; MANNITOL 20% IN PLASTIC CONTAINER; OSMITROL 15% IN WATER IN PLASTIC CONTAINER; MANNITOL 15% W/ DEXTROSE 5% IN SODIUM CHLORIDE 0.45%; MANNITOL 5%; MANNITOL 5% W/ DEXTROSE 5% IN SODIUM CHLORIDE 0.12%; RESECTISOL IN PLASTIC CONTAINER; ARIDOL KIT; OSMITROL 5% IN WATER IN PLASTIC CONTAINER; OSMITROL 10% IN WATER; OSMITROL 10% IN WATER IN PLASTIC CONTAINER; MANNITOL 10%; ARIDOL
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
maculansin B  0   Mannitol/*analogs & derivatives. Phytochemistry. 2008 Dec;69(17):2966-71
maculansin A  0   Mannitol/*analogs & derivatives. Phytochemistry. 2008 Dec;69(17):2966-71
2,5-anhydro-3,4-di-O-benzylmannitol  0   Mannitol/*analogs & derivatives. Carbohydr Res 2005 May 1;341(6):776-81
mannitol hexaacetate  0   *Acetates Mannitol/*analogs & derivatives. Forensic Sci Int 2004 Oct 4;145(1):41-6
2,5-dideoxy-2,5-imino-D-mannitol  0   Mannitol/*analogs & derivatives Imino Pyranoses. Bioorg Med Chem. 2004 Jul 1;12(13):3485-95
New-Fill  0   *Cellulose *Mannitol *Lactic Acid Cosmetic Techniques. J Oral Pathol Med 2004 Feb;33(2):115-20
montanide ISA 51  0   *Oleic Acids Mannitol/*analogs & derivatives Oils. Expert Rev Vaccines. 2002 Jun;1(1):111-8
1,6-dimethylmannitol  0   Mannitol/*analogs & derivatives. Ann N Y Acad Sci 2001 Apr;928:261-73
PAGGS-M solution  0   *Adenine *Glucose *Guanosine *Mannitol Blood Preservation. Anasthesiol Intensivmed Notfallmed Schmerzther 2001 Mar;36 Suppl 1:S6-10
1,2,5,6-O-dicyclohexylidenemannitol  0   Mannitol/*analogs & derivatives. Org Lett 2001 Feb 22;3(4);503-5
PB-3 flush solution  0   *Adenosine *Allopurinol *Mannitol *Verapamil Organ Preservation Solutions. Transpl Int 1994;7 Suppl 1:S469-71
PB-2 flush solution  0   *Adenosine *Mannitol Hypertonic Solutions. Transpl Int 1994;7 Suppl 1:S465-8
1-deoxy-1-((N-(phosphonomethyl)-2-oxoethyl)amino)mannitol-6-phosphate  0   *Sugar Phosphates Mannitol/*analogs & derivatives. Bioorg Med Chem 1999 Dec;7(12):2671-82
1-amino-2,5-anhydro-1-deoxymannitol  0   Mannitol. Carbohydr Res 1999 Feb 28;315(3-4):339-44
2,3,4,5-tetra-O-acetyl-1,6-di-O-(triphenylmethyl)mannitol  0   Mannitol/*analogs & derivatives. Acta Crystallogr C 1996 Feb 15;52 Pt 2:381-3
3,4-di-O-acetyl-2,5-anhydro-1,6-di-O-(4-tolylsulfonyl)mannitol  0   *Tosyl Compounds Mannitol/*analogs & derivatives. Acta Crystallogr C 1995 Sep 15;51( Pt 9):1921-3
3,4-di-O-acetyl-2,5-anhydro-1,6-dideoxy-1,6-diiodo-mannitol  0   Mannitol/*analogs & derivatives. Carbohydr Res 1995 Apr 19;269(2):191-200
CP 11EB  0   Glucose Mannitol Cardioplegic Solutions. J Heart Lung Transplant 1994 Sep-Oct;13(5):882-90
LAP-1 solution  0   *Disaccharides *Mannitol Solutions Tissue Preservation. Transplant Proc 1994 Dec;26(6):3412
Wallwork solution  0   *Albumins *Chlorides *Mannitol *Propionic Acids Solutions. Ann Thorac Surg 1994 Sep;58(3):845-50
Celsior  0   Disaccharides Electrolytes Glutamates Glutathione Histidine Mannitol Cardioplegic Solutions Organ Preservation Solutions. Eur J Cardiothorac Surg 1994;8(4):207-13
2,5-anhydro-1-O-(4-tolylsulfonyl)mannitol  84447-04-1   *Tosyl Compounds Mannitol/*analogs & derivatives. Carbohydr Res 1993 Mar 17;241:55-61
2,5-anhydro-3,4-O-(1,2-ethanediyl)mannitol  149297-15-4   Mannitol/*analogs & derivatives. Carbohydr Res 1992 Jun 16;230(2):213-22
MAP solution  0   *Adenine *Mannitol Blood Preservation. Rinsho Ketsueki 1992 Feb;33(2):148-56
Sendai cocktail  0   Drug Combinations Mannitol Phenytoin Vitamin E. Neurol Med Chir (Tokyo) 1991 Jun;31(6):318-25
technetium Tc 99m mannitol  0   *Organotechnetium Compounds Mannitol/*analogs & derivatives. Int J Rad Appl Instrum (B) 1989;16(3):283
1,2-dideoxy-3,4,5,6-di-O-isopropylidene-1,2-C-methylene-1-nitromannitol  110085-92-2   Mannitol/*analogs & derivatives. Carbohydr Res 1988;174:291
1,4-dideoxy-1,4-iminomannitol  95189-02-9   Mannitol/*analogs & derivatives Imino Furanoses Mannosidases/antagonists & inhibitors. Arch Biochem Biophys 1985;243(1):35
Stanford cardioplegic solution  0   Bicarbonates Glucose Mannitol Potassium Chloride Sodium Chloride Cardioplegic Solutions. Curr Surg 1985;42(3):198
manniprus  96478-25-0 D-Mannitol, 6-imino-5-methyl-3-phenyl-, (R)  *Mannitol *Nitroprusside Drug Combinations. Eksp Med Morfol 1984;23(4):222
2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine  59920-31-9 D-Mannitol, 2,5-dideoxy-2,5-imino-, (6R-(6alpha,7alpha,7(R*)))  *Alkaloids Mannitol/*analogs & derivatives Imino Furanoses. J Biol Chem 1984;259(20):12409
1,5-anhydro-mannitol  492-93-3   Mannitol/*analogs & derivatives. Carbohydr Res 1984;129:87
glymarite  77621-88-6   *Glycerol *Mannitol Drug Combinations. Zh Vopr Neirokhir 1984;(2):32
mannopinic acid  74524-18-8   Mannitol/*analogs & derivatives. J Bacteriol 1984;158(2):650
mannopine  87084-52-4   Mannitol/*analogs & derivatives. J Bacteriol 1984;158(2):650
agropinic acid  74474-75-2   Mannitol/*analogs & derivatives. J Bacteriol 1984;158(2):650
Mede-Prep  0   *Dietary Fiber *Mannitol. Australas Radiol 1983;27(3):230
Bretschneider cardioplegic solution  0   Glucose Mannitol Potassium Chloride Procaine Cardioplegic Solutions Hypertonic Solutions Organ Preservation Solutions. Scand J Thorac Cardiovasc Surg 1983;17(3):265
ADSOL  0   *Adenine *Glucose *Mannitol *Sodium Chloride Blood Preservation. Transfusion 1983;23(2):165
2,5-anhydromannitol  41107-82-8 D-Mannitol, 2,5-anhydro  Mannitol/*analogs & derivatives. Biochim Biophys Acta 1981;675(3-4):322
rheogluman  0   *Dextrans *Mannitol Drug Combinations Plasma Substitutes. Klin Khir 1980;(3):4
A32390A  61241-59-6 1,6-di-0-(2-isocyano-3-methylcrotonyl)-D-mannitol  Mannitol/*analogs & derivatives Dopamine beta-Hydroxylase/antagonists & inhibitors. Adv Enzym Regul 15:267;1977; J Antibiot 31(1):19;1978; J Antibiot 31(1):27;1978; J Antibiot 31(1):33;1978
dianhydromannitol  19895-66-0 1,2:5,6-dianhydro-D-mannitol  Mannitol/*analogs & derivatives. Biochem Pharmacol 25(15):1705;1976; Eur J Cancer 11(3):169;1975
isomannide dinitrate  551-43-9 1,4,3,6-dianhydro-D-mannitol dinitrate  Mannitol/*analogs & derivatives. Biochem Pharmacol 22(1):67;1973
mannide monooleate  25339-93-9   *Oleic Acids Mannitol/*analogs & derivatives Oils.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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