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Maytansine

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Definition: An ansa macrolide isolated from the MAYTENUS genus of East African shrubs.     
Pharmacological Action Antineoplastic Agents, Phytogenic; Tubulin Modulators 		Other names Maitansine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
SAR 3419  0   *Antibodies, Monoclonal, Humanized Maytansine/*analogs & derivatives Immunotoxins. Clin Cancer Res. 2009 Jun 15;15(12):4038-45.
maytansinol  0   Maytansine/*analogs & derivatives. J Med Chem 1978 Jan;21(1):31-7
trastuzumab-DM1 conjugate  0   *Antibodies, Monoclonal, Humanized Maytansine/*analogs & derivatives Immunotoxins. Cancer Res 2008 Nov 15;68(22):9280-90
N2'-deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine  0   Maytansine/*analogs & derivatives. Clin Cancer Res 2009 Jun 15;15(12):4038-45
N-methylmaysenine  0   Maytansine/*analogs & derivatives. Org Lett 2009 Apr 16;11(8):1809-12
EC131 conjugate  0   *Folic Acid *Maytansine. Cancer Res 2007 Jul 1;67(13):6376-82
dechloroansamitocin P-3  0   Maytansine/*analogs & derivatives. Org Lett 2007 Apr 12;9(8):1489-92
bivatuzumab mertansine  0   *Antibodies, Monoclonal, Humanized Maytansine/*analogs & derivatives. Int J Oncol 2007 Apr;30(4):927-35
seco-proansamitocin  0   Maytansine/*analogs & derivatives. Org Lett. 2006 Jan 5;8(1):135-8
DM1 compound  0   Maytansine/*analogs & derivatives. Protein Sci 2005 Sep;14(9):2436-46
N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine  0   *Sulfhydryl Compounds Maytansine/*analogs & derivatives. J Pharm Sci. 2005 Apr;94(4):788-97
N(2')-deacetyl-N(2')-(3-mercapto-1-oxopropyl)maytansine  0   Maytansine/*analogs & derivatives. Cancer Res 2004 Jul 1;64(13):4629-36
cantuzumab mertansine  0   *Antibodies, Monoclonal, Humanized Maytansine/*analogs & derivatives. J Pharmacol Exp Ther. 2004 Mar;308(3):1073-82
N-desmethyl-4,5-desepoxymaytansinol  0   Maytansine/*analogs & derivatives. J Am Chem Soc 2002 Jun 12;124(23):6544-5
2 0-demethoxy-20-((4-azidobenzoyl)oxy)maytansinol-3-isobutyrate  150422-36-9   *Azides Maytansine/*analogs & derivatives. Bioconjug Chem 1993 Jul-Aug;4(4):284-9
20-demethoxy-20-(3-(((5-dimethylamino)naphthalen-1-yl)sulfonyl)amino)propylmaytansinol-3-isobutyrate  150422-35-8   *Dansyl Compounds Maytansine/*analogs & derivatives. Bioconjug Chem 1993 Jul-Aug;4(4):284-9
trewiasine  78987-26-5   Maytansine/*analogs & derivatives. Chung Kuo Yao Li Hsueh Pao 1988;9(6):508
15-methoxyansamitocin P-3  117860-08-9 Maytansine, 2'-de(acetylmethylamino)-15-methoxy-2'-methyl  Maytansine/*analogs & derivatives. J Nat Prod 1988;51(5):845
maytanprine  38997-09-0   Maytansine/*analogs & derivatives. Yao Hsueh Hsueh Pao 1981;16(8):628
normaytansine  75983-74-3 Maytansine, 22-demethyl  Maytansine/*analogs & derivatives. J Nat Prod 1980;43(5):637
ansamitocins  69279-90-9   Maytansine/*analogs & derivatives.
Pharma Action Tubulin Modulators 		Nature 270(5639):721;1977
colubrinol  50657-33-5   Maytansine/*analogs & derivatives. Cancer Treat Rep 60(8):1022;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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