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Melphalan

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Definition: An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.     
Pharmacological Action Antineoplastic Agents, Alkylating; Myeloablative Agonists
Examples Peptichemio 		Other names Sarkolysin; Sarcolysine; Phenylalanine Mustard; Merphalan; Medphalan; Mustard, Phenylalanine; L-PAM; 4-(Bis(2-chloroethyl)amino)phenylalanine; AlkeranDrugs* : MELPHALAN HYDROCHLORIDE; ALKERAN
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
prophalan  0   Melphalan/*analogs & derivatives Proline/*analogs & derivatives. Mol Pharm 2005 Jan-Feb;2(1):37-46
MDT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Dexamethasone Melphalan Thalidomide. Int J Hematol 2007 Jul;86(1):69-71
methyl 3-(4-(bis(2-chloroethyl)amino)phenyl)-2-(2-(4-((N-isopropyl)amidino)phenyl)furan-5-carboxamido)propanoate  0   *Amidines Melphalan/*analogs & derivatives DNA Topoisomerases, Type II/antagonists & inhibitors. Biochem Pharmacol 2006 Jul 28;72(3):320-31
MOPPEBVCAD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Doxorubicin/*analogs & derivatives Lomustine Mechlorethamine Melphalan Prednisone Procarbazine Vinblastine Vincristine Vindesine. J Clin Oncol. 2005 Dec 20;23(36):9198-207
MEC regimen  0   *Antineoplastic Combined Chemotherapy Protocols Etoposide Melphalan Carboplatin. Bone Marrow Transplant 2002 Dec;30(12):893-8
TMC regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Melphalan Topotecan. Gynecol Oncol 2001 Sep;82(3):420-6
FBM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Melphalan Vidarabine/analogs & derivatives. Bone Marrow Transplant. 2000 Aug;26(3):243-50
ROAD-IN protocol  0   *Antineoplastic Combined Chemotherapy Protocols Dexamethasone Melphalan Nitrosourea Compounds Vincristine Interferon-alpha. Br J Haematol 2000 Jun;109(4):805-14
MMC protocol  0   Cyclophosphamide *Antineoplastic Combined Chemotherapy Protocols Melphalan Semustine. Hua Hsi I Ko Ta Hsueh Hsueh Pao 1998 Dec;29(4):407-10
BEM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Etoposide Melphalan. Bone Marrow Transplant 2000 Feb;25(3):309-13
monohydroxymelphalan  0   Melphalan/*analogs & derivatives. J Pharm Biomed Anal 1999 Jul;20(3):439-47
C-Mel  0   *Cephalosporins Melphalan/*analogs & derivatives. Biochem Conj 1998 Mar-Apr;9(2):255-9
1-(4-butanoyl-(4-bis(2-chloroethyl)amino)phenylalanine ethyl ester)-7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one  0   *Benzodiazepinones Melphalan/*analogs & derivatives. J Med Chem 1997 May 23;40(11):1726-30
PAMP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Melphalan. Ann Oncol 1996 Jan;7(1):65-70
MAC conditioning regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Cytarabine Melphalan. Chin Med J (Engl) 1996 Apr;109(4):304-7
MFP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Melphalan Medroxyprogesterone Acetate. Gynecol Oncol 1995 Nov;59(2):243-8
CMCp protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Melphalan Carboplatin. Aust N Z J Med 1994 Jun;24(3):288-95
CAV regimen  0   *Antineoplastic Combined Chemotherapy Protocols Etoposide Lomustine Melphalan. Ann Oncol 1994 May;5(5):427-32
MCNU-VMP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Melphalan Nitrosourea Compounds Prednisolone Vindesine. Int J Hematol 1994 Feb;59(2):113-23
Dexa-BEAM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cytarabine Dexamethasone Etoposide Melphalan. J Clin Oncol 1994 Mar;12(3):580-6
MP combination  0   *Antineoplastic Combined Chemotherapy Protocols Melphalan Prednisolone. Am J Hematol 1994 Mar;45(3):262-4
alpha-MSH-melphalan conjugate  0   alpha-MSH/*analogs & derivatives Melphalan/*analogs & derivatives Immunotoxins. Ann N Y Acad Sci 1993 May 31;680:391-400
PAVe protocol 1  0   *Antineoplastic Combined Chemotherapy Protocols Melphalan Procarbazine Vinblastine. Ann Oncol 1992 Nov;3(9):747-54
1,3-dipalmitoyl-2-(4'-(bis(2''-chloroethyl)amino)phenylalaninoyl)glycerol  144558-52-1   *Diglycerides Melphalan/*analogs & derivatives. Artzneimittelforschung 1992 Sep;42(9):1153-6
OMEC regimen  0   *Antineoplastic Combined Chemotherapy Protocols Etoposide Melphalan Vincristine Carboplatin. Eur J Cancer 1992;28A(8-9):1302-2
CMVP regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Melphalan Prednisone Vincristine. Haematologica 1991 Jul-Aug;76(4):289-92
VCSP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Melphalan Prednisolone Vincristine. Ter Arkh 1991;63(7):61-4
melphalan-N-4-hydroxyphenoxyacetamide  131089-09-3   Melphalan/*analogs & derivatives. Cancer Immunol Immunother 1990;31(4):202
PFT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Melphalan Tamoxifen. J Clin Oncol 1990;8(6):1005
PAFT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Fluorouracil Melphalan Tamoxifen. J Clin Oncol 1990;8(6):1005
COMPA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Melphalan Prednisone Vincristine. Rev Invest Clin 1989;41(4):345
MOCCA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Lomustine Melphalan Methylprednisolone Vincristine. Eur J Haematol 1989;43(4):329
CAVP protocol  0   Lomustine *Antineoplastic Combined Chemotherapy Protocols Etoposide Melphalan Prednisone. Haematologica (Pavia) 1989;74(3):273
MiNa protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Melphalan Peptichemio Prednisone Vincristine. Cancer 1989;64(4):789
MMPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Melphalan Nitrosourea Compounds Prednisolone Procarbazine. Gan To Kagaku Ryoho 1989;16(4 Pt 1):863
VAMP-ME protocol  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Melphalan Methylprednisolone Vincristine. Br J Haematol 1989;71(2):213
BEAM regimen  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cytarabine Etoposide Melphalan. Cancer Chemother Pharmacol 1988;22(3):256
ABCM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cyclophosphamide Doxorubicin Melphalan. Hematol Oncol 1988;6(2):145
VBAMDex protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Dexamethasone Doxorubicin Melphalan Vincristine. Eur J Haematol 1988;40(3):245
metamelfalan  1088-80-8   Melphalan/*analogs & derivatives. Eur J Cancer Clin Oncol 1987;23(6):783
beta-alanylmelphalan  112710-37-9   *Dipeptides Melphalan/*analogs & derivatives. Cancer Chemother Pharmacol 1987;19(3):190
MPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Melphalan Prednisone Procarbazine. Rev Med Chil 1986;114(5):436
antineoplastic agent K 18  0   Melphalan Immunoglobulin G. Nippon Gan Chiryo Gakkai Shi 1986;21(9):89
N-acetylmelphalan  5786-56-1   Melphalan/*analogs & derivatives. Cancer Res 1987;47(1):62
PMP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Melphalan Peptichemio Prednisone. Anticancer Res 1986;6(2):297
VMP-3 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Melphalan Prednisone Vincristine. Scand J Haematol 1985;35(5):518
VinMCP protocol  0   Melphalan *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Prednisone Vindesine. Cancer 1986;57(2):226
BEAM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cytarabine Melphalan Podophyllotoxin. Cancer Chemother Pharmacol 1986;16(2):170
K-18 conjugate  0   *gamma-Globulins *Melphalan Immunotoxins. Jpn J Surg 1985;15(2):173
FMVMP regimen  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Melphalan Methotrexate Prednisone Vincristine. Radiology 1985;154(3):601
BMP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Melphalan Prednisone. Cancer Treat Rep 1984;68(12):1439
MPCCV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Melphalan Prednisone Semustine Vincristine. J Clin Oncol 1984;2(7):836
MMM protocol 1  0   *Antineoplastic Combined Chemotherapy Protocols Melphalan Methotrexate Mitomycin. Cancer Chemother Pharmacol 1984;13(1):36
(COMPADRI)-III protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Melphalan Methotrexate Vincristine. Cancer 1984;53(12):2615
CAD protocol 1  0   *Antineoplastic Combined Chemotherapy Protocols Lomustine Melphalan Vindesine. Am J Med 1984;76(2):270
enkephalin-Leu, Ala(2)-melphalan methyl ester  88457-22-1 L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-N-(N-(N-(N-(N-L-tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)-L-leucyl)-, methyl ester  Melphalan/*analogs & derivatives Enkephalin, Leucine-2-Alanine/*analogs & derivatives. Life Sci 1983;33 suppl 1:435
MCPD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Melphalan Prednisolone. Eur J Cancer Clin Oncol 1983;19(10):1361
isopropyl melphalan  57675-29-3   Melphalan/*analogs & derivatives. Biomaterials 1983;4(3):197
VMCP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Melphalan Prednisone Vincristine. Pol Tyg Lek 1983;38(16):481-4
PMF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Melphalan Methotrexate. Cancer 1983;51(2):181
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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