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Metalloendopeptidases

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Definition: ENDOPEPTIDASES which use a metal such as ZINC in the catalytic mechanism.     
Examples Botulinum Toxins; Collagenases; Gelatinases; Insulysin; Lysostaphin; Matrix Metalloproteinases; Neprilysin; PHEX Phosphate Regulating Neutral Endopeptidase; Pregnancy-Associated Plasma Protein-A; Procollagen N-Endopeptidase; Pronase; Thermolysin 		Other names Metalloendopeptidase; Metallo-Endoproteinases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
SAK-RGD-K2-Hirul  EC 3.4.24.-   *Hirudins *Metalloendopeptidases *Recombinant Fusion Proteins. Acta Biochim Pol. 2009;56(1):41-53.
NRD1 protein, human  EC 3.4.24.61   *Metalloendopeptidases Alcohol-Related Disorders. J Psychiatr Res. 2011 Nov;45(11):1419-25
stromal processing peptidase, Arabidopsis  EC 3.4.24.-   *Metalloendopeptidases *Arabidopsis Proteins Chloroplast Proteins. PLoS One. 2011;6(8):e23039.
BlaR1 protein, Staphylococcus aureus  EC 3.4.24.-   *Bacterial Proteins *Metalloendopeptidases Membrane Proteins Intracellular Signaling Peptides and Proteins. Antimicrob Agents Chemother. 1993 May;37(5):1144-9.
Pitrm1 protein, mouse  EC 3.4.24.-   *Metalloendopeptidases. Dev Dyn 20009 Dec;238(12):3175-84
Afg3l1 protein, mouse  EC 3.4.24.-   *Metalloendopeptidases. Genomics 2001 Aug;76(1-3):58-65
staphylokinase SFH  EC 3.4.24.-   *Metalloendopeptidases *Recombinant Fusion Proteins. J Thromb Thrombolysis 2007 Dec;24(3):283-92
S2P metalloprotease, Methanocaldococcus jannaschii  EC 3.4.24.-   *Bacterial Proteins *Metalloendopeptidases. Science. 2007 Dec 7;318(5856):1608-12
SAK-RGD-K2-Hir  0   *Hirudins *Metalloendopeptidases *Recombinant Fusion Proteins. Thromb Haemost 2007 Jun;97(6):1037-45
VAP2 protein, Crotalus atrox  EC 3.4.24.-   *Crotalid Venoms *Metalloendopeptidases. Eur J Biochem 1998 Apr 1;253(1):36-41
DPY-31 protein, C elegans  EC 3.4.-   *Metalloendopeptidases *Caenorhabditis elegans Proteins. Genetics 2004 Nov;168(3):259-73
halysase, Gloydius halys  EC 3.4.24.-   *Crotalid Venoms *Metalloendopeptidases. J Biochem (Tokyo) 2003 Nov;134(5):739-49
berythractivase, Bothrops erythromelas  EC 3.4.24.-   *Crotalid Venoms *Metalloendopeptidases. Biol Chem 2005 Apr;386(4):369-74
Ste23 protein, S cerevisiae  EC 3.4.24.-   *Metalloendopeptidases *Saccharomyces cerevisiae Proteins. J Biol Chem 2005 Jul 29;280(30):27481-90
ADAMTS13 protein, mouse  EC 3.4.24.-   *Metalloendopeptidases. J Thromb Haemost 2005 May;3(5):1064-73
ZmpA protein, Burkholderia cenocepacia  EC 3.4.24.-   *Bacterial Proteins *Metalloendopeptidases. J Bacteriol 2005 Jul;187(13):4421-9
invadolysin, human  EC 3.4.24.-   *Metalloendopeptidases. J Cell Biol 2004 Nov 22;167(4):673-86
invadolysin, Drosophila  EC 3.4.24.-   *Metalloendopeptidases *Drosophila Proteins. J Cell Biol 2004 Nov 22;167(4):673-86
BjussuMP-I  EC 3.4.24.-   *Metalloendopeptidases Snake Venoms. Toxicon. 2004 Aug;44(2):215-23
ECEL1 protein, human  EC 3.4.24.-   *Metalloendopeptidases.
Ecel1 protein, rat  EC 3.4.24.-   *Metalloendopeptidases.
MMP23A protein, human  EC 3.4.24.-   *Metalloendopeptidases.
Spg7 protein, mouse  EC 3.4.24.-   *Metalloendopeptidases.
dactylysin, Xenopus  EC 3.5.24.60   *Metalloendopeptidases *Xenopus Proteins. Comp Biochem Physiol B Biochem Mol Biol. 2002 Aug;132(4):751-9
STE24 protein, S cerevisiae  EC 3.4.24.-   *Membrane Proteins *Metalloendopeptidases *Saccharomyces cerevisiae Proteins.
Zmpste24 protein, mouse  EC 3.4.24.-   *Membrane Proteins *Metalloendopeptidases.
chloroplast processing enzyme protein, Arabidopsis  EC 3.4.24.-   *Metalloendopeptidases *Arabidopsis Proteins Protein Processing, Post-Translational.
Kae1 protein, S cerevisiae  EC 3.4.24.-   *Metalloendopeptidases *Saccharomyces cerevisiae Proteins. Biochem J 2004 Jan 15;377(Pt 2):395-405
ProB protein, Ehrlichia canis  EC 3.4.24.-   *Bacterial Proteins *Metalloendopeptidases. DNA Seq 2003 Apr;14(2):109-21
ProA protein, Ehrlichia canis  EC 3.4.24.-   *Bacterial Proteins *Metalloendopeptidases. DNA Seq 2003 Apr;14(2):109-21
AmpA protein, Dictyostelium protozoan  EC 3.4.24.-   *Metalloendopeptidases *Protozoan Proteins. J Muscle Res Cell Motil. 2002;23(7-8):817-28
ZmpC protein, Streptococcus pneumoniae  EC 3.4.24.-   *Metalloendopeptidases. Mol Microbiol 2003 Aug;49(3):795-805
halydin protein, Gloydius halys  EC 3.4.24.-   *Metalloendopeptidases. Biochem Biophys Res Commun 2003 Sep 26;309(3):637-42
basparin A, Bothrops asper  EC 3.4.24.-   *Crotalid Venoms *Metalloendopeptidases. Arch Biochem Biophys 2003 Oct 1;418(1):13-24
molecule metalloprotease-related protein-1, human  EC 3.4.24.-   *Metalloendopeptidases. DNA Res 2003 Jun 30;10(3);123-8
factor X activator, Russell's viper  EC 3.4.24.-   *Metalloendopeptidases *Viper Venoms. Haemostasis 2001 May-Dec;31(3-6):
factor X activator, Vipera lebetina  EC 3.4.24.-   *Metalloendopeptidases *Viper Venoms. Haemostasis 2001 May-Dec;31(3-6):123-32
UNC-71 protein, C elegans  EC 3.4.24.-   *Metalloendopeptidases *Caenorhabditis elegans Proteins Disintegrins. Development 2003 Jul;130(14):3147-61
xolloid-related protein, Xenopus  EC 3.4.24.-   *Metalloendopeptidases. Mech Dev 2002 Dec;119(2);177-90
FACE-2 protein, C elegans  EC 3.4.22.-   *Metalloendopeptidases *Caenorhabditis elegans Proteins. Biochem J 2003 Mar 15;370(Pt 3):1047-54
FACE-1 protein, C elegans  EC 3.4.22.-   *Caenorhabditis elegans Proteins *Metalloendopeptidases. Biochem J 2003 Mar 15;370(Pt 3):1047-54
agkistin, Agkistrodon halys  EC 3.4.24.-   *Crotalid Venoms *Metalloendopeptidases. Biochem Biophys Res Commun 2003 Feb 7;301(2):298-303
bothropasin, Bothrops jararaca  EC 3.4.24.-   *Crotalid Venoms *Metalloendopeptidases. Toxicon 2003 Feb;41(2):217-27
Mop protein, Vibrio cholerae  EC 3.4.24.-   *Metalloendopeptidases. Infect Immun 2003 Jan;71(1):510-5
TM-3 protein, Trimeresurus mucrosquamatus  EC 3.4.24.-   *Crotalid Venoms *Metalloendopeptidases. Acta Crystallogr D Biol Crystallogr 2002 Jul;58(Pt 7):1118-28
mikarin  EC 3.4.24.-   *Elapid Venoms *Metalloendopeptidases. Arch Biochem Biophys 2002 Dec 1;408(1):87-92
hemorrhagic toxin HR-1a, Trimeresurus flavoviridis  EC 3.4.24.-   *Metalloendopeptidases *Viper Venoms. Toxicon 2002 Sep;40(9):1369-75
Rri1 protein, S cerevisiae  EC 3.4.24.-   *Metalloendopeptidases *Saccharomyces cerevisiae Proteins. Science 2002 Oct 18;298(5593):608-11
VfpA protein, Vibrio fluvialis  EC 3.4.24.-   *Bacterial Proteins *Metalloendopeptidases. Microb Pathog 2002 Sep;33(3):127-34
StcE protein, E coli  EC 3.4.24.-   *Metalloendopeptidases *Escherichia coli Proteins. Mol Microbiol 2002 Jul;45(2):277-88
testase 4, human  EC 3.4.24.-   *Metalloendopeptidases. Gene 2002 Apr 17;288(1-2):203-10
PEGylated staphylokinase SY161  EC 3.4.24.-   *Metalloendopeptidases *Polyethylene Glycols. J Pharm Biomed Anal 2002 Jun 1;28(5):953-63
InhA2 protein, Bacillus thuringiensis  EC 3.4.24.-   *Bacterial Proteins *Metalloendopeptidases. J Bacteriol 2002 Jun;184(12):3296-304
MTP-1 protein, Ancylostoma caninum  EC 3.4.24.-   *Metalloendopeptidases. Mol Biochem Parasitol 2002 Apr 9;120(2):291-6
N(4)-(2,2-dimethyl-1-methylcarbamoylpropyl)-N(1)-hydroxy-2-hydroxymethyl-3-(4-methoxyphenyl)succinamide  0   *Hydroxamic Acids Metalloendopeptidases/antagonists & inhibitors Matrix Metalloproteinases/antagonists & inhibitors. J Med Chem 2002 May 23;45(11):2289-93
Adt-1 protein, C elegans  0   *Metalloendopeptidases *Caenorhabditis elegans Proteins. J Biol Chem 2002 Apr 5;277(14):12228-36
AG3433  0   *Furans *Nitriles *Pyrroles Metalloendopeptidases/antagonists & inhibitors. J Org Chem 2002 Mar 8;67(5):1699-702
MEP-1 protein, Ancylostoma caninum  EC 3.4.24.-   *Metalloendopeptidases *Helminth Proteins. Mol Biochem Parasitol 2002 Jan;119(1):107-16
BB 3644  0   *Aminopyridines *Hydroxamic Acids Metalloendopeptidases/antagonists & inhibitors. Int J Cancer 2002 Mar 10;98(2):210-5
N-hydroxy-2-((2,2-difluoroethoxy)(4-methoxyphenyl)phosphoryl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide  0   *Hydroxylamines *Tetrahydroisoquinolines Metalloendopeptidases/antagonists & inhibitors. J Med Chem 2002 Feb 14;45(4):930-6
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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