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Methotrexate

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Definition: An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.     
Pharmacological Action Abortifacient Agents, Nonsteroidal; Dermatologic Agents; Antimetabolites, Antineoplastic; Antirheumatic Agents; Enzyme Inhibitors; Folic Acid Antagonists; Immunosuppressive Agents; Nucleic Acid Synthesis Inhibitors 		Other names Amethopterin; Sodium Salt Methotrexate; Hydrate, Methotrexate; Disodium Salt Methotrexate; Dicesium Salt Methotrexate; Mexate; Methotrexate, Sodium Salt; Methotrexate, Disodium Salt; Methotrexate, Dicesium Salt; Methotrexate, (DL)-Isomer; Methotrexate, (D)-Isomer; Methotrexate HydrateDrugs* : METHOTREXATE SODIUM; TREXALL; MEXATE-AQ; FOLEX PFS; MEXATE-AQ PRESERVED; METHOTREXATE LPF; METHOTREXATE SODIUM PRESERVATIVE FREE; ABITREXATE; METHOTREXATE PRESERVATIVE FREE; MEXATE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
methotrexate-alpha-benzyl-gamma-hexadecyl ester  0   Methotrexate/*analogs & derivatives. Chem Phys Lipids 2009 Feb;157(2):94-103
methotrexate-gamma-hexadecyl ester  0   Methotrexate/*analogs & derivatives. Chem Phys Lipids 2009 Feb;157(2):94-103
AWO54  0   Methotrexate/*analogs & derivatives Prodrugs. Ann Rheum Dis. 2008 Aug;67(8):1188-91
POG-8498 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Azacitidine Cytarabine Daunorubicin Etoposide Methotrexate Prednisone Thioguanine Vincristine 6-Mercaptopurine. Pediatr Blood Cancer 2007 Mar;48(3):262-7
MATILDE regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Methotrexate Thiotepa Idarubicin. Neurology 2006 May 9;66(9):1435-8
methotrexate-GIVGPL-dextran  0   *Dextrans *Methotrexate *Oligopeptides. J Pharm Sci 2006 Mar;95(3):542-51
methotrexate-PVGLIG-dextran  0   *Dextrans *Methotrexate *Oligopeptides. J Pharm Sci 2006 Mar;95(3):542-51
APO combination  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Methotrexate Prednisone Vincristine 6-Mercaptopurine. J Clin Oncol 2005 Jan 20;23(3):541-7
MBVP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Methotrexate Methylprednisolone Teniposide. Neurology 2004 Feb 24;62(4):544-7
MEA regimen  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Dactinomycin Etoposide Methotrexate. J Reprod Med 2004 Jun;49(6):438-42
PETHEMA ALL-3-97 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Cyclophosphamide Cytarabine Dexamethasone Etoposide Ifosfamide Methotrexate Prednisone Vincristine. Leuk Lymphoma 2003 Sep;44(9):1541-3
BEMOP-CA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Doxorubicin Etoposide Methotrexate Prednisolone Vincristine. Int J Oncol 2003 Feb;22(2):421-4
ALL-85 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Dexamethasone Etoposide Methotrexate Teniposide Vincristine 6-Mercaptopurine/analogs & derivatives. Leuk Res 2003 Jan;27(1):45-50
ALL-82 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Doxorubicin Methotrexate Teniposide 6-Mercaptopurine/analogs & derivatives. Leuk Res 2003 Jan;27(1):45-50
ALL-80 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Methotrexate 6-Mercaptopurine/analogs & derivatives. Leuk Res 2003 Jan;27(1):45-50
BOP-CISCA-POMB-ACE regimen  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cisplatin Cyclophosphamide Dactinomycin Doxorubicin Etoposide Methotrexate Vincristine. Br J Cancer 2002 May 20;86(10):1555-60
MAPO protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Methotrexate Prednisone Vincristine. Leukemia 2001 Jun;15(6):898-902
Rizzoli IOR protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Doxorubicin Ifosfamide Methotrexate. J Chemother 2001 Feb;13(1):93-9
LMB89 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Cyclophosphamide Cytarabine Doxorubicin Etoposide Hydrocortisone Methotrexate Prednisone Vincristine. Blood 2001 Jun 1;97(11):3370-9
BMC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Lomustine Methotrexate. Gynecol Oncol 2001 Jun;81(3):348-54
LBCMVD-56 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Chlorambucil Dexamethasone Lomustine Methotrexate Vincristine. Ann Oncol. 2000 Jul;11(7):857-60
M-FLP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Fluorouracil Methotrexate. Am J Clin Oncol 2000 Jun;23(3):314-8
DTPA-methotrexate  0   Pentetic Acid/*analogs & derivatives Methotrexate/*analogs & derivatives Indium Radioisotopes. Cancer Biother Radiopharm 1998 Jun;13(3):177-84
HELP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Ifosfamide Methotrexate Vindesine. Ann Oncol 1999 Sep;10(9):1065-71
4-amino-10-methylpteroylhexa-gamma-glutamic acid  0   Methotrexate/*analogs & derivatives. Brain Res 1999 Oct 2;843(1-2):48-52
MPEpiV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Methotrexate Vincristine Epirubicin. Breast Cancer Res Treat 1999 Jul;56(2):125-32
MPEpiE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Etoposide Methotrexate Epirubicin. Breast Cancer Res Treat 1999 Jul;56(2):125-32
MPEMi protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Etoposide Methotrexate Mitomycin. Breast Cancer Res Treat 1999 Jul;56(2):125-32
HCVAD protocol  0   Cytarabine *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Dexamethasone Doxorubicin Methotrexate Vincristine. Clin Cancer Res 1999 Sep;5(9):2491-7
m-BOP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cisplatin Ifosfamide Methotrexate Vincristine. Ann Oncol 1999 Jun;10(6):685-92
VEPA-L protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Doxorubicin Methotrexate Prednisolone Vincristine. Jpn J Clin Oncol 1999 Jul;29(7):340-8
MAE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Dactinomycin Etoposide Methotrexate. Br J Cancer 1999 Mar;79(9-10):1531-3
HM 91 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Doxorubicin Etoposide Methotrexate Prednisone Vinblastine Vincristine. Blood 1998 Nov 15;92(10):3591-8
HM 89 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Etoposide Methotrexate Prednisone Vincristine. Blood 1998 Nov 15;92(10):3591-8
BMPD protocol  0   Carmustine Dexamethasone *Antineoplastic Combined Chemotherapy Protocols Leucovorin Methotrexate Procarbazine. Leukemia Lymphoma 1998 Aug;30(5-6):609-17
CAPABLE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cisplatin Cyclophosphamide Doxorubicin Methotrexate. J Clin Oncol 1998 Jul;16(7):2514-21
DVP-M-CHOP protocol  0   DNA *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Methotrexate Prednisolone Vincristine. Rinsho Ketsueki 1998 Mar;39(3):176-84
MCNO regimen  0   *Antineoplastic Combined Chemotherapy Protocols Methotrexate Mitoxantrone Vincristine Carboplatin. Oncology 1998 Mar-Apr;55(2):139-44
DAVTHML regimen  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Fluoxymesterone Methotrexate Mitolactol Tamoxifen Vincristine. Am J Clin Oncol 1998 Feb;21(1):99-104
VEMP protocol 3  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Methotrexate Prednisolone Vindesine. Br J Cancer 1997;76(11):1484-8
MLL-93 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Leucovorin Cyclophosphamide Cytarabine Dexamethasone Etoposide Hydrocortisone Hydroxyurea Methotrexate Mitoxantrone. Leuk Res 1997 Sep;21(9):811-5
MIMO protocol  0   *Antineoplastic Combined Chemotherapy Protocols Methotrexate Mitoxantrone Vincristine. Oncology 1997 Sep-Oct;54(5):371-5
AIEOP 8703 protocol  0   Asparaginase *Antineoplastic Combined Chemotherapy Protocols Leucovorin Daunorubicin Methotrexate Prednisone Vincristine 6-Mercaptopurine. Blood 1997 Aug 1;90(3):1226-32
NCI PB 93-C-207 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Methotrexate. Blood 1997 May 15;89(10):3700-7
VBM protocol 2  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Methotrexate Vinblastine. J Clin Oncol 1997 May;15(5):1736-44
POG 8602 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cytarabine Hydrocortisone Methotrexate Prednisone Vincristine 6-Mercaptopurine. Blood 1990 Jul 1;76(1):117-22
N-(5-(beta-(2,4-diamino-6-pteridinyl)ethyl)-2-thenoyl)glutamic acid  0   Methotrexate/*analogs & derivatives. J Med Chem 1997 Jan 31;40(3):370-6
N-(1-((2,4-diamino-6-pteridinyl)methyl)-3,4-dihydro -2H-1,4-benzothiazine-7-carbonyl)-L-2-aminoadipic acid  0   Methotrexate/*analogs & derivatives 2-Aminoadipic Acid/*analogs & derivatives. Immunopharmacology 1996 Oct;35(1):41-6
OOS-A regimen  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Methotrexate. Cancer 1997 Jan 15;79(2):411-5
fluorescein-methotrexate  0   *Fluoresceins Methotrexate/*analogs & derivatives. Am J Physiol 1996 Dec;271(6 Pt 2):F1173-82
M-DOMP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Daunorubicin Methotrexate Prednisone Vincristine 6-Mercaptopurine. Leuk Lymphoma 1996 Jun;22(1-2):71-6
BVMM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Methotrexate Mitolactol Vincristine. Neoplasma 1996;43(1):51-6
MSK-NY-II protocol, modified  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Daunorubicin Methotrexate Prednisolone Vincristine. Med Pediatr Oncol 1996 Sep;27(3):139-44
methotrexate-N,N'-bis(dodecylamide)  0   Methotrexate/*analogs & derivatives. Anticancer Drug Des 1996 Apr;11(3):253-64
methotrexate-N,N'-bis(decylamide)  136181-93-6   Methotrexate/*analogs & derivatives. Anticancer Drug Des 1996 Apr;11(3):253-64
BFM-86 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cyclophosphamide Cytarabine Methotrexate Prednisone Vincristine 6-Mercaptopurine. Blood 1996 Jun 15;87(12):5207-12
MCHOD protocol  0   Leucovorin *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Dexamethasone Doxorubicin Methotrexate Vincristine. Neurology 1996 Jun;46(6):1757-9
IVAM regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Etoposide Ifosfamide Methotrexate. Cancer 1996 Jun 1;77(11):2302-7
HR-3 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Cytarabine Dexamethasone Etoposide Methotrexate Prednisolone. Blood 1996 Apr 15;87(8):3143-50
HR-2 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Asparaginase Daunorubicin Dexamethasone Ifosfamide Methotrexate Prednisolone Thioguanine Vindesine. Blood 1996 Apr 15;87(8):3143-50
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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