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Methylmalonic Acid

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Definition: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.  /biosyn /physiol permitted    Other names Acid, Methylmalonic
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
butyl-2-methyl-malonic acid  0   Methylmalonic Acid/*analogs & derivatives Biological Markers. Apoptosis 2009 Mar;14(3):257-67
Malonic aciduria  0   *Metabolism, Inborn Errors Carboxy-Lyases/deficiency Methylmalonic Acid.
5-fluoropentyl-2-methylmalonic acid  0   Methylmalonic Acid/*analogs & derivatives Fluorine Radioisotopes. J Nucl Med 2008 Sep;49(9):1520-8
N,N'-dimethyl-2-dimethylmalondiamide  155199-55-6   Methylmalonic Acid/*analogs & derivatives. Int J Pept Protein Res 1994 Mar;43(3):258-63
N,N'-dimethyl-2-methylmalondiamide  13566-69-3   Methylmalonic Acid/*analogs & derivatives. Int J Pept Protein Res 1994 Mar;43(3):258-63
N,N'-bis(3,4-ditrifluoromethylphenyl)methylmalonamide  60131-74-0 Propanediamide, N,N'-bis(3,4-bis(trifluoromethyl)phenyl)-2-methyl  Methylmalonic Acid/*analogs & derivatives. Parasitology 78(1):33;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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