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Methyltransferases

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Definition: A subclass of enzymes of the transferase class that catalyze the transfer of a methyl group from one compound to another. (Dorland, 28th ed) EC 2.1.1.     
Examples Acetylserotonin O-Methyltransferase; Betaine-Homocysteine S-Methyltransferase; Catechol O-Methyltransferase; DNA Modification Methylases; Glycine N-Methyltransferase; Guanidinoacetate N-Methyltransferase; Histamine N-Methyltransferase; Homocysteine S-Methyltransferase; 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Nicotinamide N-Methyltransferase; Phenylethanolamine N-Methyltransferase; Phosphatidyl-N-Methylethanolamine N-Methyltransferase; Phosphatidylethanolamine N-Methyltransferase; Protein Methyltransferases; Thymidylate Synthase; tRNA Methyltransferases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Crg1 protein, S cerevisiae  EC 2.1.1.-   *Methyltransferases *Saccharomyces cerevisiae Proteins. PLoS Genet. 2011 Oct;7(10) (dup#4):e1002332
RID2 protein, Arabidopsis  EC 2.1.1.-   *Methyltransferases *Arabidopsis Proteins Nuclear Proteins. Plant J. 2011 Jul;67(1):49-60.
QUA3 protein, Arabidopsis  EC 2.1.1.-   *Methyltransferases *Arabidopsis Proteins. J Exp Bot. 2011 Oct;62(14):5063-78.
fibrillarin 2, Arabidopsis  EC 2.1.1.-   *Methyltransferases. Nucleic Acids Res. 2011 Nov 1;39(20):8869-80.
HMTR1 protein, human  EC 2.1.1.-   *Methyltransferases. Nucleic Acids Res 2011 Jun;39(11):4756-68
HMTR2 protein, human  EC 2.1.1.-   *Methyltransferases. Nucleic Acids Res 2011 Jun;39(11):4756-68
Nsp16 protein, SARS virus  EC 2.1.1.-   *Methyltransferases *Viral Nonstructural Proteins. Acta Crystallogr Sect F Struct Biol Cryst Commun 2011 Mar 1;67(Pt 3):404-8
RlmN protein, E coli  EC 2.1.1.-   *Methyltransferases *Escherichia coli Proteins. Science. 2011 Apr 29;332(6029):604-7
NpmA protein, E coli  EC 2.1.1.-   *Methyltransferases *Escherichia coli Proteins. Antimicrob Agents Chemother 2007 Dec;51(12):4401-9
Hen1 protein, zebrafish  EC 2.1.1.-   *Methyltransferases *Zebrafish Proteins. EMBO J 2010 Nov 3;29(21):3688-700
YibK protein, E coli  EC 2.1.1.-   *Methyltransferases *Escherichia coli Proteins. RNA 2010 Nov;16(11):2131-43
PRMT2 protein, mouse  EC 2.1.1.-   *Methyltransferases. Circ Res 2010 Oct 15;107(8):992-1001
MidA protein, human  EC 2.1.1.-   *Methyltransferases. J Cell Sci 2010 May 15;123(Pt 10):1674-83
NRMT protein, human  EC 2.1.1.-   *Methyltransferases. Nature. 2010 Aug 26;466(7310):1125-8
QUASIMODO2 protein, Arabidopsis  EC 2.1.1.-   *Methyltransferases *Arabidopsis Proteins. Plant Mol Biol 2010 Aug;73(6):605-15
EMG1 protein, human  EC 2.1.1.-   *Methyltransferases *Nuclear Proteins. Nucleic Acids Res 2010 Apr 1;38(7):2387-98
RsmI protein, E coli  EC 2.1.1.-   *Methyltransferases *Escherichia coli Proteins. Nucleic Acids Res 2010 Mar 1;38(4):1341-52
RsmH protein, E coli  EC 2.1.1.-   *Methyltransferases *Escherichia coli Proteins. Nucleic Acids Res 2010 Mar 1;38(4):1341-52
RumA protein, E coli  EC 2.1.1.-   *Methyltransferases. Biochem Biophys Res Commun 2010 Feb 5;392(2):223-7
7SK methylphosphate capping enzyme, human  EC 2.1.1.-   *Methyltransferases. Nucleic Acids Res 2010 Feb;38(2):360-9
SHTAP protein, mouse  EC 2.1.1.-   *Carrier Proteins *Methyltransferases. Biol Cell 2010;102(2):93-106
BSMT1 protein, Arabidopsis  EC 2.1.1.-   *Methyltransferases *Arabidopsis Proteins. Mol Cells 2009 Aug;28(2):105-9
METT-10 protein, C elegans  EC 2.1.1.-   *Methyltransferases *Caenorhabditis elegans Proteins. Genetics 2009 Sep;183(1):233-47
HOL1 protein, Arabidopsis  EC 2.1.1.-   *Methyltransferases *Arabidopsis Proteins. J Biol Chem 2009 Jul 17;284(29):19301-9
YfiC protein, E coli  EC 2.1.1.-   *Methyltransferases *Escherichia coli Proteins. RNA 2009 Jun;15(6):1134-41
ATXR6 protein, Arabidopsis  EC 2.1.1.-   *Methyltransferases *Arabidopsis Proteins. Nat Struct Mol Biol. 2009 Jul;16(7); 763-8
ATXR5 protein, Arabidopsis  EC 2.1.1.-   *Methyltransferases *Arabidopsis Proteins. Nat Struct Mol Biol. 2009 Jul;16(7); 763-8
STRM-1 protein, C elegans  EC 2.1.1.-   *Methyltransferases *Caenorhabditis elegans Proteins. Dev Cell 2009 Jun;16(6):833-43
N6A1 protein, mouse  EC 2.1.1.-   *Methyltransferases. Mol Biol Rep 2009 Apr;36(4):767-74
RmtB protein, E coli  EC 2.1.1.-   *Methyltransferases *Escherichia coli Proteins. J Mol Biol 2009 May 8;388(3):570-82
TAE1 protein, S cerevisiae  EC 2.1.1.-   *Methyltransferases *Saccharomyces cerevisiae Proteins. BMC Genomics 2008;9:583
Cfr protein, E coli  EC 2.1.1.-   *Methyltransferases *Escherichia coli Proteins. Antimicrob Agents Chemother 2006 Jul;50(7):2500-5
C20orf7 protein, human  EC 2.1.1.-   *Methyltransferases *Mitochondrial Proteins. Am J Hum Genet 2008 Oct;83(4):468-78
RlmH protein, E coli  EC 2.1.1.-   *Methyltransferases *Escherichia coli Proteins. RNA 2008 Oct;14(10):2223-33
AS3MT protein, mouse  EC 2.1.1.137   *Methyltransferases. Amino Acids 2008 Aug;35(2):355-8
rebeccamycin 4'-O-methyltransferase, Lechevalieria aerocolonigenes  EC 2.1.1.-   *Methyltransferases. J Biol Chem 2008 Aug 15;283(33):22628-36
HemK2alpha protein, human  EC 2.1.1.22   *Methyltransferases. FEBS Lett 2008 Jul 9;582(16):2352-6
juvenile hormone acid O-methyltransferase, Drosophila  EC 2.1.1.-   *Methyltransferases *Drosophila Proteins. Insect Biochem Mol Biol 2008 Jul;38(7):714-20
HMPrmC protein, human  EC 2.1.1.-   *Methyltransferases. Biochem Biophys Res Commun 2008 Aug 15;373(1):99-103
ISG95 protein, human  EC 2.1.1.-   *Methyltransferases. Biochem Biophys Res Commun 2008 Aug 8;372(4):719-24
diphthine synthase, Pyrococcus horikoshii  EC 2.1.1.-   *Methyltransferases. Acta Crystallogr D Biol Crystallogr 2008 Apr;64(Pt 4):397-406
PRMT10 protein, Arabidopsis  EC 2.1.1.-   *Methyltransferases *Arabidopsis Proteins. EMBO Rep 2007 Dec;8(12):1190-5
nucleomethylin protein, human  EC 2.1.1.-   *Methyltransferases *Nuclear Proteins. Cell 2008 May 16;133(4):627-39
Set11 protein, S pombe  EC 2.1.1.-   *Methyltransferases *Schizosaccharomyces pombe Proteins. J Biol Chem 2008 Mar 14;283(11):7185-95
16-methoxytabersonine methyltransferase, Catharanthus roseus  EC 2.1.1.-   *Methyltransferases. Plant J 2008 Jan;53(2):225-36
RsmE protein, E coli  EC 2.1.1.-   *Methyltransferases *Escherichia coli Proteins. RNA 2007 Nov;13(11):1969-76
PRMT11 protein, Arabidopsis  EC 2.1.1.-   *Methyltransferases *Arabidopsis Proteins. Plant J 2007 Oct;52(2):210-22
Hen1 protein, Drosophila  EC 2.1.1.-   *Methyltransferases *Drosophila Proteins. Curr Biol 2007 Jul 17;17(14):1265-72
YJR129C protein, S cerevisiae  EC 2.1.1.-   *Methyltransferases *Saccharomyces cerevisiae Proteins. Acta Biochim Pol 2006;53(4):739-45
Nsun7 protein, mouse  EC 2.1.1.-   *Methyltransferases. Biol Reprod 2007 Aug;77(2):376-82
aziridine N-methyltransferase, Streptomyces lavendulae  EC 2.1.1.-   *Methyltransferases. J Biol Chem 2007 Jul 20;282(29):20941-7
Pimet protein, Drosophila  EC 2.1.1.-   *Methyltransferases *Drosophila Proteins. Genes Dev 2007 Jul 1;21(13):1603-8
GAMT2 protein, Arabidopsis  EC 2.1.1.-   *Methyltransferases *Arabidopsis Proteins. Plant Cell 2007 Jan;19(1):32-45
GAMT1 protein, Arabidopsis  EC 2.1.1.-   *Methyltransferases *Arabidopsis Proteins. Plant Cell 2007 Jan;19(1):32-45
RsmD protein, E coli  EC 2.1.1.-   *Methyltransferases *Escherichia coli Proteins. BMC Bioinformatics 2002 Apr 3;3:10
NSUN2 protein, human  EC 2.1.1.-   *Methyltransferases. Nucleic Acids Res 2006;34(20):6034-43
Suv39h1 protein, zebrafish  EC 2.1.1.-   *Methyltransferases *Zebrafish Proteins. Mol Cell Biol 2006 Oct;26(19):7077-85
CheR protein, E coli  EC 2.1.1.-   *Methyltransferases *Escherichia coli Proteins. Cell 1981 Nov;26(3 Pt 1):333-43
Misu protein, mouse  EC 2.1.1.-   *Methyltransferases. Curr Biol 2006 May 23;16(10):971-81
S-adenosyl-L-methionine-phosphoethanolamine N-methyltransferase, C elegans  EC 2.1.1.103   *Methyltransferases *Caenorhabditis elegans Proteins. Biochemistry 2006 May 16;45(19):6056-65
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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