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Mianserin

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Definition: A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.     
Pharmacological Action Adrenergic alpha-Antagonists; Antidepressive Agents, Second-Generation; Histamine H1 Antagonists; Serotonin Antagonists 		Other names Monohydrochloride, Mianserin; Hydrochloride, Mianserin; Tolvon; Org GB 94; Mianserin Monohydrochloride; Mianserin Hydrochloride; Lerivon
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
mirtazapine-N-oxide  0   *Cyclic N-Oxides Mianserin/*analogs & derivatives. Drug Metab Dispos 2002 Nov;30(11):1274-9
desmethylmirtazapine  0   Mianserin/*analogs & derivatives. Drug Metab Dispos 2000 Oct;28(10):1168-75
(N-methyl)mianserin  0   Mianserin/*analogs & derivatives. Nucl Med Biol 2002 Apr;29(3):317-9
6-methoxymianserin  0   Mianserin/*analogs & derivatives. J Med Chem 2002 Jul 18;45(15):3280-5
8-hydroxymirtazapine  0   Mianserin/*analogs & derivatives. J Pharmacol Exp Ther 2000 Nov;295(2):793-801
demethylmirtazapine  0   Mianserin/*analogs & derivatives.
FCC13  119200-45-2 Dibenzo(c,f)pyrazino(1,2-a)azepine-2(1H)-carboxamide, 3,4,10,14b-tetrahydro  Mianserin/*analogs & derivatives. Clin Exp Pharmacol Physiol 1992 Jan;19(1):25-30
2-N-carboxamidinonormianserin  139995-66-7 Dibenzo(c,f)pyrazino(1,2-a)azepine-2(1H)-carboximidamide, 3,4,10,14b-tetrahydro-, monohydrochloride  Mianserin/*analogs & derivatives. Clin Exp Pharmacol Physiol 1992 Jan;19(1):25-30
Org 3770 glucuronide  125426-33-7   *Glucuronates Mianserin/*analogs & derivatives. Xenobiotica 1990;20(1):133
desmethylmianserin  71936-92-0   Mianserin/*analogs & derivatives. Neuropsychobiology 1987;18(3):118
Org 2305  53245-50-4   Mianserin/*analogs & derivatives. Br J Clin Pharmacol 1987;23(2):219
setiptiline  57262-94-9   Mianserin/*analogs & derivatives. Pol J Pharmacol Pharm 1986;38(4):377
mirtazapine  61337-67-5 Pyrazino(2,1-a)pyrido(2,3-c)(2)benzazepine, 1,2,3,4,10,14b-hexahydro-2-methyl  Mianserin/*analogs & derivatives Carbon Radioisotopes.
Pharma Action Adrenergic alpha-Antagonists ; Antidepressive Agents, Tricyclic ; Histamine H1 Antagonists 		Naunyn Schmiedebergs Arch Pharmacol 1982;319(1):48REMERON SOLTAB; REMERON; MIRTAZAPINE
8-hydroxydesmethylmianserin  77117-73-8 Dibenzo(c,f)pyrazino(1,2-a)azepin-8-ol, 1,2,3,4,10,14b-hexahydro  Mianserin/*analogs & derivatives. Drug Metab Dispos 1981;9(1):48
8-hydroxymianserin  57257-81-5 2H-dibenzo(c,f)pyrazino(1,2-a)azepin-8-ol, 1,2,3,4,10,14b-hexahydro-2-methyl  Mianserin/*analogs & derivatives. Drug Metab Dispos 1981;9(1):48

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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