encyclopedia of medical concepts
ψ 
ψ 

Misonidazole

More information in Books or onNLM PubMed
Definition: A nitroimidazole that sensitizes normally radio-resistant hypoxic cells to radiation. It may also be directly cytotoxic to hypoxic cells and has been proposed as an antineoplastic.     
Pharmacological Action Antineoplastic Agents; Antiprotozoal Agents; Radiation-Sensitizing Agents 		Other names Ro 70582; Ro 7 0582; Ro 070582; Ro 07 0582; alpha-(Methoxymethyl)-2-nitro-1H-imidazole-1-ethan; Ro 7-0582; Ro 07-0582
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4,5-dimethylmisonidazole  22896-05-5   Misonidazole/*analogs & derivatives. Biochem Pharmacol 1992 Mar 17;43(6):1337-44
5-(2-nitroimidazolyl)-4-hydroxy-1-iodopent-1-ene  133933-39-8   Misonidazole/*analogs & derivatives. J Med Chem 1991;34(7):2165
RSU 1137  99464-91-2   Misonidazole/*analogs & derivatives. Biochem Pharmacol 1991;41(11):1649
1-(2-nitro-1-imidazoyl)-3-(2,2,2-trifluoroethoxy)-2-propanol  21787-91-7   Misonidazole/*analogs & derivatives. Int J Radiat Oncol Biol Phys 1989;16(4):911
RK 29  93679-12-0 2-Butyn-1-ol, 4-((2-nitro-1H-imidazol-1-yl)methoxy)  Misonidazole/*analogs & derivatives. Nippon Gan Chiryo Gakkai Shi 1988;23(1):13
RSU 1131  88876-89-5 1H-Imidazole-1-ethanol, alpha-((2-methyl-1-aziridinyl)methyl)-2-nitro  Misonidazole/*analogs & derivatives. Biochem Pharmacol 1987;36(11):1787
2-amino-4,5-dihydro-4,5-dihydroxy-1-(2'-hydroxy-3'-methoxy-1'-propyl)imidazole  104939-15-3   Misonidazole/*analogs & derivatives. Int J Radiat Oncol Biol Phys 1986;12(7):1227
RSU 1164  88876-94-2 1H-Imidazole-1-ethanol, .alpha.-[(2,3-dimethyl-1-aziridinyl)methyl]-2-nitro  Misonidazole/*analogs & derivatives. Int J Radiat Oncol Biol Phys 1986;12(7):1087
RSU 1172  104970-07-2 1H-Imidazole-1-ethanol, alpha-((2-(1-methylethyl)-1-aziridinyl)methyl)-2-nitro  Misonidazole/*analogs & derivatives. Int J Radiat Oncol Biol Phys 1986;12(7):1087
RB 7040  105027-76-7 1H-Imidazole-1-ethanol, 2-nitro-.alpha.-[(2,2,3,3-tetramethyl-1-aziridinyl)methy]  Misonidazole/*analogs & derivatives. Int J Radiat Oncol Biol Phys 1986;12(7):1083
1-(4'-hydroxy-2'-butenoxy)methyl-2-nitroimidazole  101179-42-4   Misonidazole/*analogs & derivatives. Nippon Igaku Hoshasen Gakkai Zasshi 1985;45(8):1142
misonidazole-glutathione conjugate  86356-71-0   Glutathione/*analogs & derivatives Misonidazole/*analogs & derivatives. Int J Radiat Oncol Biol Phys 1984;10(8):1341
1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol  88876-88-4 1H-Imidazole-1-ethanol, alpha-(1-aziridinylmethyl)-2-nitro  Misonidazole/*analogs & derivatives.
Pharma Action Antineoplastic Agents ; Radiation-Sensitizing Agents 		Br J Cancer 1984;49(5):571
2,2'-azoxymisonidazole  78130-16-2   Misonidazole/*analogs & derivatives. Int J Radiat Biol 1984;45(5):469
2,2'-azomisonidazole  78130-17-3   Misonidazole/*analogs & derivatives. Int J Radiat Biol 1984;45(5):469
2-aminomisonidazole  76620-73-0   Misonidazole/*analogs & derivatives. Gann 1983;74(5):693
2-hydroxyaminomisonidazole  78524-63-7   Misonidazole/*analogs & derivatives. Gann 1983;74(5):693
Ro 07-1902  68160-71-4   Misonidazole/*analogs & derivatives. Br J Cancer 1983;48(1):17
misonidazole glucuronide  86589-32-4 beta-D-Glucopyranosiduronic acid, 1-(methoxymethyl)-2-(2-nitro-1H-imidazol-1-yl)ethyl  Misonidazole/*analogs & derivatives. Biochem Pharmacol 1983;32(10):1609
4-bromomisonidazole  83200-90-2 1H-Imidazole-1-ethanol, 4-bromo-alpha-(methoxymethyl)-2-nitro  Misonidazole/*analogs & derivatives. Radiat Res 1982;91(3):542
fluoromisonidazole  13551-89-8   Misonidazole/*analogs & derivatives.
Pharma Action Radiation-Sensitizing Agents 		Rad Res 1981;87(3):670
desmethylmisonidazole  13551-92-3 3-(2-nitro-I-imidazolyl)-1,2-propanediol  Misonidazole/*analogs & derivatives.
Pharma Action Mutagens ; Radiation-Sensitizing Agents 		Int J Radiat Biol 34(1):91;1978; Mutation Res 31(3):149;1975

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy