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Mitotane

More information in Books or onNLM PubMed
Definition: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.  TN 111 for eff on insects   
Pharmacological Action Antineoplastic Agents, Hormonal 		Other names ortho,para-DDD; o,p-DDD; Bristol Myers Squibb Brand of Mitotane; ortho,para DDD; Mytotan; Lysodren; Khloditan; Chlodithane; Chloditan; Bristol-Myers Squibb Brand of MitotaneDrugs* : LYSODREN
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-(4-chlorophenyl)-2-(4-chloro-3-thiophenol)-1,1-dichlorethene  0   Mitotane/*analogs & derivatives. Chemosphere 2009 Aug;76(6):805-10
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  3424-82-6   Mitotane/*analogs & derivatives. Clin Chim Acta 1987;170(2-3):305
2,2-(2-chlorophenyl-4'-chlorophenyl)acetic acid  34113-46-7   Mitotane/*analogs & derivatives. Clin Chim Acta 1987;170(2-3):305
mitometh  107465-03-2 Benzene, 1-chloro-2-(2,2-dichloro-1-(4-chlorophenyl)propyl)  Mitotane/*analogs & derivatives. Toxicol Appl Pharmacol 1987;87(1):1
1-(2-chlorophenyl)-1-(4-iodophenyl)-2,2-dichloroethane  16608-69-8   Mitotane/*analogs & derivatives. Toxicol Appl Pharmacol 1985;77(1):47

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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