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Mixed Connective Tissue Disease

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Definition: A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a "speckled" epidermal nuclear staining pattern on direct immunofluorescence.  disease entity: read definition & do not confuse with CONNECTIVE TISSUE DISEASES; DF: MCTD    Other names Sharp Syndrome; Connective Tissue Disease, Mixed; MCTD; Syndrome, Sharp

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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