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Mollusk Venoms

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Definition: Venoms from mollusks, including CONUS and OCTOPUS species. The venoms contain proteins, enzymes, choline derivatives, slow-reacting substances, and several characterized polypeptide toxins that affect the nervous system. Mollusk venoms include cephalotoxin, venerupin, maculotoxin, surugatoxin, conotoxins, and murexine.  /antag permitted but consider also ANTIVENINS; /enzymol permitted; coordinate IM with specific mollusk (IM or NIM)   
Pharmacological Action Poisons
Examples Conotoxins; Eledoisin 		Other names Snail Venoms; Octopus Venoms; Conus Venoms; Venoms, Snail; Venoms, Octopus; Venoms, Mollusk; Venoms, Mollusc; Venoms, Conus; Venom, Snail; Venom, Octopus; Venom, Mollusk; Venom, Conus; Snail Venom; Octopus Venom; Mollusk Venom; Mollusc Venoms; Conus Venom
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PV2 protein, Pomacea canaliculata  0   *Mollusk Venoms Neurotoxins. Biochim Biophys Acta. 2010 Jul;1804(7):1492-9
turritoxin pal9a, Polystira albida  0   *Mollusk Venoms. Peptides 2009 Mar;30(3):467-76
conantokin-E  0   *Conotoxins Mollusk Venoms. Toxicon. 2008 Aug 1;52(2):203-13
conantokin-P  0   *Conotoxins Mollusk Venoms. Toxicon. 2008 Aug 1;52(2):203-13
conorfamide-Sr2, Conus spurius  0   *Mollusk Venoms *Neuropeptides. Peptides 2008 Feb;29(2):186-95
conopressin-T, Conus tulipa  0   Oxytocin/*analogs & derivatives Mollusk Venoms. J Biol Chem 2008 Mar 14;283(11):7100-8
furanoyessotoxin  0   *Oxocins Mollusk Venoms. J Agric Food Chem 2007 Dec 26;55(26):11093-100
gamma-conopressin-vil, Conus villepinii  0   *Mollusk Venoms Oxytocin/*analogs & derivatives. Biochem J 2007 Jun 15;404(3):413-9
yessotoxin 32-O-(beta-L-arabinofuranosyl-(5'-1'')-beta-L-arabinofuranoside), Protoceratium reticulatum  0   *Oxocins *Mollusk Venoms. Toxicon 2006 Apr;47(5):510-6
conkunitzin-S1, Conus striatus  0   *Mollusk Venoms. J Biol Chem 2005 Jun 24;280(25):23766-70
carboxyyessotoxin  0   *Oxocins Mollusk Venoms. Toxicon 2005 Jul;46(1):7-15
9-methyl-41a-homoyessotoxin  0   *Oxocins Mollusk Venoms. Toxicon. 2005 Jan;45(1):61-7
41a-homoyessotoxin  0   *Oxocins Mollusk Venoms. Toxicon. 2005 Jan;45(1):61-7
glacontryphan M  0   *Mollusk Venoms *Peptides, Cyclic. J Biol Chem 2004 Jul 30;279(31):32453-63
alpha-conotoxin PIA, Conus purpurascens  0   *Mollusk Venoms Conotoxins. J Neurosci 2003 Sep 17;23(24):8445-52
conophysin-R, Conus radiatus  0   *Mollusk Venoms. Toxicon 2002 Jul;40(7):901-8
conorfamide  0   *Mollusk Venoms *Neuropeptides. Toxicon 2002 Apr;40(4):401-7
45-hydroxyyessotoxin  0   *Ethers, Cyclic Mollusk Venoms. Biosci Biotechnol Biochem 2000 Aug;64(8):1761-3
conotoxin TVIIA  0   *Mollusk Venoms Toxins, Biological. Eur J Biochem 2000 Aug;267(15):4642-8
1-desulfoyessotoxin  0   *Ethers, Cyclic Mollusk Venoms. Nat Toxins 1998 ;6(6):235-9
glycyl-cysteinyl-valyl-leucyl-leucyl-prolyl-tryptophyl-cysteine (2-7)disulfide  0   *Peptides, Cyclic Mollusk Venoms. J Pept Res 1999 Aug;54(2):93-9
conantokin ET  0   *Peptides, Cyclic Mollusk Venoms. FEBS Lett 1997 Apr 28;407(2):243-8
R13Q  0   *Peptides, Cyclic Mollusk Venoms. Neuron 1996 Feb;16(2):407-13
contryphan  0   *Peptides, Cyclic Mollusk Venoms. J Biol Chem 1996 Nov 8;271(45):28002-5
SNX 202  0   *Peptides Mollusk Venoms. J Mol Biol 1996 Oct 25;263(2):297-310
omega-conotoxin TxVII  0   *omega-Conotoxins Mollusk Venoms. Biochemistry 1996 Jul 2;35(26):8748-52
MDM protein, Lymnaea stagnalis  0   *Mollusk Venoms. Eur J Immunol 1996 Apr;26(4):939-44
kahalalide F  149204-42-2   *Depsipeptides Mollusk Venoms. Cancer Lett 1996 Jan 19;99(1):43-50
conodipine M  EC 3.1.1.4   *Phospholipases A2, Secretory Mollusk Venoms. J Biol Chem 1995 Feb 24;270(8):3518-26
yessotoxin  112514-54-2   *Oxocins Mollusk Venoms. Toxicon 1990;28(9):1095
conotoxin GI, des-Glu(1)  92137-82-1   *Conotoxins Mollusk Venoms. Int J Pept Protein Res 1989;34(6):455
conantokin-T  127476-26-0   *Mollusk Venoms *Peptides.
Pharma Action Excitatory Amino Acid Antagonists 		J Biol Chem 1990;265(11):6025
onchidal  67656-42-2 2-Butenal, 2-(2-(acetyloxy)ethenyl)-4-(2,2-dimethyl-6-methylenecyclohexyl)-, (E,E)-(+)  *Terpenes Mollusk Venoms. Mol Pharmacol 1989;36(3):349
prosurugatoxin  99102-40-6 D-myo-Inositol, 4-(6'-bromo-1,1',2',3,4,6,8,8a,9,10-decahydro-6-hydroxy-6-methyl-2,2',4-trioxospiro(cyclopenta(e)pyrimido(4,5-b)(1,4)diazepine-7(2H),3'-(3H)indole)-8-carboxylate), (6S-(6alpha,7alpha,8alpha,8aalpha))  *Mollusk Venoms Snails. Chem Pharm Bull (Tokyo) 1985;33(7):2890
conotoxin GIII  101484-15-5 Conotoxin G III  *Conotoxins Mollusk Venoms Sodium Channels. J Biol Chem 1985;260(16):9280
geographutoxin II  86414-29-1 Geographutoxin I, 8-L-arginine-14-L-arginine-18-L-methionine-19-L-lysine  *Peptides, Cyclic Mollusk Venoms. FEBS Lett 1983;155(2):277
geographutoxin I  86394-16-3   *Peptides, Cyclic Mollusk Venoms Neurotoxins. FEBS Lett 1983;155(2):277
tessulatoxin  85497-48-9 Tessulatoxin  *Mollusk Venoms. Comp Biochem Physiol 1983;74B(3):381
neosurugatoxin  80680-43-9   *Mollusk Venoms Snails. Chem Pharm Bull (Tokyo) 1982;30(9):3255
striatoxin protein, Conus striatus  82030-90-8 Striatoxin  *Glycoproteins *Mollusk Venoms. Biochem Biophys Res Commun 1982;105(4):1389
conotoxin GI  76862-65-2 Conotoxin G I  *Conotoxins Mollusk Venoms. J Biol Chem 1981;156(10):4734
hepalotoxin  77536-28-8 Hepalotoxin  *Mollusk Venoms. Toxicon 15(5):463;1977
surugatoxin  40957-92-4   *Mollusk Venoms Snails. Br J Pharmacol 53:207;1975; Br J Pharmacol 58:157;1976; Folia Pharmacol Jpn 73(6):657;1977; Jpn J Pharmacol 1979;29(3):295; Jpn J Pharmacol 24(4):559;1974; Lloydia 38(1):1;1975
IS-toxin  0   *Mollusk Venoms. Jpn J Pharmacol 24(4):559;1974

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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