encyclopedia of medical concepts
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Morphinans

More information in Books or onNLM PubMed
Definition: Compounds based on a partially saturated iminoethanophenanthrene, which can be described as ethylimino-bridged benzo-decahydronaphthalenes. They include some of the OPIOIDS found in PAPAVER that are used as ANALGESICS.     
Examples Benzomorphans; Buprenorphine; Butorphanol; Dextromethorphan; Dextrorphan; Diprenorphine; Etorphine; Levallorphan; Levorphanol; Morphine; Nalbuphine; Nalorphine; Naloxone
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
17-cyclopropylmethyl-6,7-didehydro-quinolino(2',3'-6,7)morphinan-4-ol  0   *Morphinans *Quinolines Receptors, Opioid, delta/agonists. Bioorg Med Chem. 2012 Jan 15;20(2):949-61.
6,7-didehydro-17-methyl-quinolino(2',3'-6,7)morphinan-4-ol  0   *Morphinans *Quinolines Receptors, Opioid, delta/agonists. Bioorg Med Chem. 2012 Jan 15;20(2):949-61.
6,7-didehydro-17-isobutyl-quinolino(2',3'-6,7)morphinan-4-ol  0   *Morphinans *Quinolines Receptors, Opioid, delta/agonists. Bioorg Med Chem. 2012 Jan 15;20(2):949-61.
4,5-epoxy-14-hydroxy sinomenine N-oxide  0   *Cyclic N-Oxides *Morphinans. J Asian Nat Prod Res. 2011 Jun;13(6):523-8
1-hydroxy-10-oxo-sinomenine  0   *Morphinans. J Asian Nat Prod Res. 2011 Jun;13(6):523-8
((17-N-cyclobutylmethyl)morphinan-3-yl-(-14-hydroxyl-17-N-cyclobutylmethyl) morphinan-3-yl) decanedioate  0   *Decanoates *Morphinans. Bioorg Med Chem. 2011 May 1;19(9):2808-16
JKB 119  0   *Morphinans. Biochem Pharmacol 2011 Apr 15;81(2):996-1003
milonine  0   *Morphinans. Bioorg Med Chem Lett 2011 Jan 15;21(2):122-30
3-N-ethylaminothiazolo(5,4-b)-N-cyclopropylmethylmorphinan hydrochloride  0   *Morphinans Receptors, Opioid, kappa/agonists. Acta Pharmacol Sin. 2010 Dec;31(12):1547-52
KNT 127  0   *Morphinans Receptors, Opioid, delta/agonists. Bioorg Med Chem Lett 2010 Nov 1;20(21):6302-5
17-cyclopropylmethyl-3,14-dihydroxy-4,5-epoxy-6-((3'-isoquinolyl)acetamido)morphinan  0   *Morphinans Receptors, Opioid, mu/antagonists & inhibitors. J Med Chem 2009 Mar 12;52(5):1416-27
17-cyclopropylmethyl-3,14-dihydroxy-4,5-epoxy-6-((4'-pyridyl)acetamido)morphinan  0   *Morphinans Receptors, Opioid, mu/antagonists & inhibitors. J Med Chem 2009 Mar 12;52(5):1416-27
phenylethyl orvinol  0   *Morphinans Carbon Radioisotopes Receptors, Opioid, mu/agonists Receptors, Opioid, kappa/agonists. J Med Chem 2009 Sep 24;52(18):5586-9
(5alpha,6alpha)-6-hydroxy-7,8-didehydro-4,5-epoxy-3-methoxy-17-methylmorphinanium dihydrogen phosphate hemihydrate  0   *Morphinans. Acta Crystallogr C. 2009 Aug;65(Pt 8):o419-22
SN-28 compound  0   *Morphinans. Bioorg Med Chem Lett 2009 May 15;19(10):2792-5
SN-23 compound  0   *Morphinans. Bioorg Med Chem Lett 2009 May 15;19(10):2792-5
3-aminothiazolo(5,4-b)-N-cyclopropylmethylmorphinan  0   *Morphinans. J Pharmacol Exp Ther 2009 Apr;329(1):306-13
NS22 compound  0   *Benzamides *Morphinans. Bioorg Med Chem Lett 2008 Dec 15;18(24):6398-401
cyclic-1,2-ethanediyl acetal 8,14-didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-one  0   *Morphinans. J Org Chem 2009 Jan 16;74(2):747-52
1-(N-cyclobutylmethylmorphinan-3-yl)-10-(N-cyclobutylmethylmorphinan-3-yl)sebacolyate  0   *Morphinans Receptors, Opioid, mu/agonists Receptors, Opioid, kappa/agonists. Neurochem Res 2008 Oct;33(10):2142-50
bis(N-cyclobutylmethylmorphinan-3-yl) sebacoylate dihydrochloride  0   *Alkanes *Morphinans Receptors, Opioid, mu/agonists Receptors, Opioid, kappa/antagonists & inhibitors Receptors, Opioid, kappa/agonists. Pharmacology. 2008;81(3):229-35
7',8'-dihydro-1,1'-disinomenine  0   *Morphinans. J Nat Prod 2008 Jan;71(1):127-9
2,2'-disinomenine  0   *Morphinans. J Nat Prod. 2008 Jan;71(1); 127-9
noroxymorphone  0   *Morphinans. Anesth Analg 2008 Feb;106(2):463-70
8,14-dihydropromorphinane  0   *Morphinans Alkaloids. Nat Prod Res 2007 Jul 20;21(9):852-6
butorphan  0   *Morphinans. J Med Chem 2006 Sep 7;49(18):5640-3
tazopsine  0   *Morphinans Antimalarials. PLoS Med 2006 Dec;3(12):e513
2-((4,5alpha-epoxy-3-hydroxy-14beta-methoxy-17-methylmorphinan-6beta-yl)amino)acetic acid  0   *Epoxy Compounds *Morphinans. J Pharmacol Exp Ther. 2006 Apr;317(1):220-7
bis(N-cyclobutylmethylmorphinan)fumarate  0   *Fumarates *Morphinans Receptors, Opioid, mu/antagonists & inhibitors Receptors, Opioid, mu/agonists Receptors, Opioid, kappa/agonists. J Pharmacol Exp Ther 2005 Nov;315(2):821-7
N-demethylsinomenine  0   *Morphinans. J Nat Prod 2005 Jul;68(7):1128-30
sinomenine N-oxide  0   *Morphinans. J Nat Prod 2005 Jul;68(7):1128-30
17-cyclopropylmethyl-3-hydroxy-(5beta,7beta,3',5')-pyrrolidino-2'(S)-phenyl-7alpha-methyl-6,14-endoetheno morphinan  0   *Bridged Compounds *Morphinans. Eur J Pharmacol. 2005 Feb 21;509(2-3):117-25
17-(cyclopropylmethyl)-4,5 alpha-epoxy-6 beta,21-epoxymethano-3-hydroxy-6,14-endoethenomorphinan-7 alpha-(N-phenethyl)carboxamide  0   *Morphinans. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4241-3
BU72 compound  0   *Morphinans *Pyrroles. Eur J Pharmacol 2004 Sep 19;499(1-2):107-16
4,5-epoxymorphinan  0   *Morphinans. Eur J Pharmacol. 2004 Jun 28;494(2-3):251-62
17-(cyclopropylmethyl)-4,5alpha-epoxy-3,6beta-dihydroxy-6,14-endoethenomorphinan-7alpha-(N-methyl-N-phenethyl)carboxamide  0   *Morphinans. Bioorg Med Chem. 2004 Aug 1;12(15):4133-45
morphinandienone  0   *Morphinans Alkaloids. Fitoterapia. 2004 Dec;75(7-8):792-4
17-cyclopropylmethyl-3,14-dihydroxy-4,5-epoxy-4'-phenyl-6,7-2',3'-pyrrolomorphinan  0   *Morphinans Receptors, Opioid, delta/antagonists & inhibitors. J Med Chem 2004 Dec 16;47(26):6645-8
7beta-methoxy-dihydro-sinomenine  0   *Morphinans. Yao Xue Xue Bao. 2004 Mar;39(3):180-3
6,7-dihydroxy-7,8- dihydro-sinomenine  0   *Morphinans. Yao Xue Xue Bao. 2004 Mar;39(3):180-3
17-(cyclopropylmethyl)-4-hydroxy-14-((3-phenylpropyl)oxy)morphinan-6-one  0   *Morphinans Receptors, Opioid, kappa/agonists. J Med Chem 2004 Jun 3;47(12):3242-7
5'-(4-chlorophenyl)-6,7-didehydro-4,5alpha-epoxy-3-hydroxy-17-methylpyrido(2',3'-6,7)morphinan  0   *Morphinans Receptors, Opioid, mu/agonists Receptors, Opioid, delta/antagonists & inhibitors. J Med Chem 2004 Mar 11;47(6):1400-12
5-(3-hydroxyphenyl)-N-phenylethylmorphan  0   *Morphinans. Bioorg Med Chem. 2002 Oct;10(10):3319-29
O-methylpallidinine  0   *Bridged Compounds *Morphinans. Org Lett 2002 Dec 12;4(25):4515-7
N-methyl-2,3,6-trimethoxyg morphinandien-7-one  0   *Morphinans. Zhong Yao Cai 2001 Feb;24(2):104-5
N-(3-iodoprop-(2)-enyl)  0   *Morphinans. Bioorg Med Chem Lett 2001 Oct 22;11(20):2735-40
N-propargyl  0   *Morphinans. Bioorg Med Chem Lett 2001 Oct 22;11(20):2735-40
(cyclopropylmethyl)-6,7-dehydro-4,5-epoxy-14-ethoxy-5-methylindolo(2',3'-6',7')morphinan-3-ol  0   *Indoles *Morphinans. Eur J Pharmacol 2001 Apr 20;418(1-2):79-87
17-(2-methyl-2-propenyl)-6,7-dehydro-4,5-epoxy-3,14-dihydroxy-6,7-2,3-indolomorphinan  0   *Morphinans Receptors, Opioid/antagonists & inhibitors. J Med Chem 2001 Apr 26;44(9):1471-4
AH019  0   *Morphinans. Synapse. 2001 Jan;39(1):64-9
17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-5'-guanidinyl-3,14-dihydroxyindolo(2',3'-6,7)morphinan  0   *Guanidines *Morphinans Receptors, Opioid, kappa/antagonists & inhibitors. J Med Chem 2000 Jul 13;43(14):2759-69
N-phenethyl-9-methyl-5-(3-hydroxyphenyl)morphan  0   *Morphinans Receptors, Opioid/antagonists & inhibitors. J Med Chem 1998 Oct 8;41(21):4143-9
N-methyl-9-methyl-5-(3-hydroxyphenyl)morphan  0   *Morphinans Receptors, Opioid/antagonists & inhibitors. J Med Chem 1998 Oct 8;41(21):4143-9
17-(cyclopropylmethyl)-6,7-didehydro--13,14-dihydroxy-5'-(2-(2-pyridinyl)ethenyl)indolo(2',3'-6,7)morphinan  0   *Indoles *Morphinans Receptors, Opioid/antagonists & inhibitors Receptors, Opioid/agonists. J Med Chem 1998 Jul 16;41(15):2872-81
17-(cyclopropylmethyl)-6,7-didehydro-4,5-epoxy-13,14-dihydroxy-7'-phenoxyindolo(2',3'-6,7)morphinan  0   *Indoles *Morphinans Receptors, Opioid/agonists Receptors, Opioid/antagonists & inhibitors. J Med Chem 1998 Jul 16;41(15):2872-81
TRK 820  0   *Morphinans *Spiro Compounds Receptors, Opioid, kappa/agonists. Chem Pharm Bull (Tokyo) 1998 Feb;46(2):366-9
N-cyclopropylmethyl-5-methyl-14-(4-chlorocinnamoylamino)-7,8-dihydronormorphinone  0   *Morphinans Receptors, Opioid, mu/antagonists & inhibitors. Eur J Pharmacol 1997 Feb 12;320(2-3):121-9
5-methyl-14-(4-chlorocinnamoylamino)-7,8-dihydromorphinone  0   *Morphinans Receptors, Opioid, mu/antagonists & inhibitors. Eur J Pharmacol 1997 Feb 12;320(2-3):121-9
perdolan  102578-49-4   *Morphinans. Am J Kidney Dis 1997 Jun;29(6):982-3
thevinone  15358-22-2   *Morphinans. Bioorg Med Chem 1997 Feb;5(2):369-82
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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