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Melanocyte-Stimulating Hormones

More information in Books or onNLM PubMed
Definition: Peptides with the ability to stimulate pigmented cells MELANOCYTES in mammals and MELANOPHORES in lower vertebrates. By stimulating the synthesis and distribution of MELANIN in these pigmented cells, they increase coloration of skin and other tissue. MSHs, derived from pro-opiomelanocortin (POMC), are produced by MELANOTROPHS in the INTERMEDIATE LOBE OF PITUITARY; CORTICOTROPHS in the ANTERIOR LOBE OF PITUITARY, and the hypothalamic neurons in the ARCUATE NUCLEUS.     
Pharmacological Action Hormones
Examples alpha-MSH; beta-MSH; gamma-MSH 		Other names Melanotropin; MSH; Melanophore Stimulating Hormone; Melanocyte Stimulating Hormones; Melanophore-Stimulating Hormone; MSH (Melanocyte-Stimulating Hormones)
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
gamma-melanocyte-stimulating factor, Trp(8)  0   *Melanocyte-Stimulating Hormones. FASEB J 2008 Dec;22(12):4228-38
GKPV peptide  0   *Peptide Fragments Melanocyte-Stimulating Hormones. Peptides 2006 Feb;27(2):431-7
alpha-melanocyte stimulating hormone (6-13), Nal(7)-Phe(12)  0   *Melanocyte-Stimulating Hormones *Peptide Fragments. J Med Chem 2003 Feb 27;46(5):850-5
alpha-MSH (5-10), Phe(7)  0   *Melanocyte-Stimulating Hormones Ligands Organotechnetium Compounds. Nucl Med Biol 1999 Aug;26(6):687-93
RMI 2004  0   *Melanocyte-Stimulating Hormones. Eur J Pharmacol 1999 Aug 13;378(3):249-58
RMI 2005  0   *Melanocyte-Stimulating Hormones *Peptide Fragments. Eur J Pharmacol 1999 Aug 13;378(3):249-58
RMI 2001  0   *Melanocyte-Stimulating Hormones. Eur J Pharmacol 1999 Aug 13;378(3):249-58
HS 028  0   *Melanocyte-Stimulating Hormones *Peptide Fragments. Br J Pharmacol 1999 Jan;126(1):27-34
MSH, alpha, 4-fluorobenzoyl-Nle(4)-Phe(7)  0   *Melanocyte-Stimulating Hormones Fluorine Radioisotopes. Nucl Med Biol 1997 Feb;24(2):171-8
SHU 9119  168482-23-3   *Melanocyte-Stimulating Hormones Receptors, Corticotropin/antagonists & inhibitors. Nature 1997 Jan 9;385(6612):165-8
DTPA bis((Nle(4)-Phe(7))-alpha-MSH)  0   *Melanocyte-Stimulating Hormones Pentetic Acid/*analogs & derivatives. Nucl Med Commun 1995 Oct;16(10):860-6
alpha-MSH, DTPA-Nle(4)-Phe(7)  0   *Melanocyte-Stimulating Hormones Pentetic Acid/*analogs & derivatives. Nucl Med Commun 1995 Oct;16(10):860-6
bis(MSH)-DTPA  129494-00-4   *Melanocyte-Stimulating Hormones Pentetic Acid/*analogs & derivatives. Ann N Y Acad Sci 1993 May 31;680:451-3
MSH (5-10), cyclic  137668-62-3   *Melanocyte-Stimulating Hormones *Peptides, Cyclic. Pigment Cell Res 1991 Oct;4(4):180-5
desacetyl-MSH (4-10)  0   *Melanocyte-Stimulating Hormones *Peptide Fragments Drug Carriers. Biochem Soc Trans 1991;18(5):882
N-acetyllysyl-prolyl-valinamide  57899-96-4   *Melanocyte-Stimulating Hormones *Peptide Fragments. Peptides 1990;11(5):979
MSH, beta, (5-22)  17750-75-3   *Melanocyte-Stimulating Hormones *Peptide Fragments. Peptides 1989;10(1):83
MSH, gamma, (15-26)  125636-77-3   *Melanocyte-Stimulating Hormones *Peptide Fragments. Med Hypotheses 1988;27(1):1
azidoiodo-beta-MSH  0   *Azides *Melanocyte-Stimulating Hormones. Endocrinology 1988;123(4):1792
MSH, beta, (5-8)  122998-76-9   *Melanocyte-Stimulating Hormones *Peptide Fragments. Biull Eksp Biol Med 1986;101(5):519
MSH-daunomycin conjugate  0   *Daunorubicin *Melanocyte-Stimulating Hormones. Methods Enzymol 1985;112:259
MSH (11-13)  67727-97-3   *Melanocyte-Stimulating Hormones *Peptide Fragments. Peptides (Fayetteville) 1984;5(4):815
MSH, beta, (6-8)  85775-46-8 L-Glutamic acid, N-(N-L-arginyl-L-valyl)  *Melanocyte-Stimulating Hormones *Peptide Fragments. Ann Ist Super Sanita 1982;18(1):7
MSH, des-Asp  77069-88-6 beta-Melanotropin, 1-de-L-aspartic acid-16-L-arginine  *Melanocyte-Stimulating Hormones. Int J Pept Protein Res 1982;19(4):327
MSH, beta, (9-18), Tyr(9)  75389-13-8 beta-Melanotropin, 1-de-L-aspartic acid-2-de-L-glutamic acid-3-deglycine-4-de-L-proline-6-de-L-lysine-7-de-L-methionine-8-de-L-glutamic acid-9-de-L-histidine  *Melanocyte-Stimulating Hormones *Peptide Fragments. Peptides 1981;2(4):389
MSH, beta, Gly(10)  61120-75-0 beta-Melanotropin, 2-glycine-8-L-glutamine-10-glycine  *Melanocyte-Stimulating Hormones. J Clin Invest 1981;68(3):752
MSH receptor  0   *Receptors, Pituitary Hormone alpha-MSH Melanocyte-Stimulating Hormones. Biochem Soc Trans 1981;9(1):37
MSH, beta, Nle(7)  70699-12-6 7-L-norleucine-beta-melanotropin (pig)  *Melanocyte-Stimulating Hormones. Hoppe Seylers Z Physiol Chem 360(12):1851;1979
ACTH (4-10)  4037-01-8 N-(N-(N(2)-(N-(N-(N-L-methionyl-L-alpha-glutamyl)-L-histidyl)-L-phenylalanyl)-L-arginyl)-L-tryptophyl)glycine  *Adrenocorticotropic Hormone *Peptide Fragments Melanocyte-Stimulating Hormones.
Pharma Action Nootropic Agents 		Ann Neurol 1(3):270;1977; Dokl Akad Nauk SSSR 240(5):1245;1978; Eur J Pharmacol 1979:57(4):353; Frontiers Hormone Res 4:129;1976; J Neurochem 32(4):977;1978; Prog Brain Res 42:163;1975; Prog Brain Res 42:187;1975; Prog Brain Res 42:209;1975; Prog Brain Res 42:275;1975; Psychopharmacology (Berlin) 61(2):161;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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