Multienzyme Complexes (definition)

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ψ ψ	Multienzyme Complexes

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Definition: Systems of enzymes which function sequentially by catalyzing consecutive reactions linked by common metabolic intermediates. They may involve simply a transfer of water molecules or hydrogen atoms and may be associated with large supramolecular structures such as MITOCHONDRIA or RIBOSOMES.

MULTIPROTEIN COMPLEXES is also available
Examples Electron Transport Complex I; Electron Transport Complex IV; Fatty Acid Synthetase Complex; Glycine Decarboxylase Complex; Ketoglutarate Dehydrogenase Complex; Phosphoenolpyruvate Sugar Phosphotransferase System; Photosynthetic Reaction Center Complex Proteins; Proteasome Endopeptidase Complex; Pyruvate Dehydrogenase Complex; Succinate Cytochrome c Oxidoreductase; Sucrase-Isomaltase Complex

Other names Complexes, Multienzyme

Substance	CAS Registry & name	Categories	Source
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, Plasmodium falciparum	0	Carboxylic Ester Hydrolases Glucosephosphate Dehydrogenase *Multienzyme Complexes Protozoan Proteins.	Biochem J 2011 Jun 15;436(3):641-50
MFE-2 protein, Drosophila	0	Alcohol Oxidoreductases Multienzyme Complexes Carbon-Oxygen Lyases Drosophila Proteins.	Biochem J 2011 May 1;435(3):771-81
enolase phosphatase, mouse	0	*Multienzyme Complexes.	Mol Psychiatry 2010 Jul;15(7):702-11
TPSO3 protein, Arabidopsis	EC 5.5.-	Multienzyme Complexes Pyrophosphatases Intramolecular Lyases Arabidopsis Proteins.	Plant Physiol 2010 Jul;153(3):1293-310
TPSO2 protein, Arabidopsis	EC 5.5.-	Multienzyme Complexes Pyrophosphatases Intramolecular Lyases Arabidopsis Proteins.	Plant Physiol 2010 Jul;153(3):1293-310
DUF299 protein, E coli	0	Multienzyme Complexes Phosphoric Monoester Hydrolases *Protein Kinases.	BMC Biochem 2010;11:1
delta(1)-pyrroline-5-carboxylate synthetase, Cenchrus	0	Multienzyme Complexes Phosphotransferases (Alcohol Group Acceptor) *Glutamate-5-Semialdehyde Dehydrogenase.	Plant Physiol Biochem 2010 Jan;48(1):27-34
U4kpxs protein, Ralstonia solanacearum	0	Alcohol Oxidoreductases Carboxy-Lyases *Multienzyme Complexes.	J Biol Chem 2010 Mar 19;285(12):9030-40
Hint4 protein, Arabidopsis	EC 3.-	Multienzyme Complexes Phosphoric Monoester Hydrolases *Sulfatases.	FEBS Lett 2010 Jan 4;584(1):93-8
isocitrate dehydrogenase kinase-phosphatase, E coli	EC 2.7.11.5	Multienzyme Complexes Escherichia coli Proteins Phosphoprotein Phosphatases Protein-Serine-Threonine Kinases.	Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 May 1;65(Pt 5):536-9
GlmU protein, Mycobacterium tuberculosis	0	Bacterial Proteins Multienzyme Complexes Acetyltransferases Nucleotidyltransferases.	Int J Biochem Cell Biol 2008;40(11):2560-71
Akr1c18 protein, rat	EC 1.1.1.50	Multienzyme Complexes 17-Hydroxysteroid Dehydrogenases *3-alpha-Hydroxysteroid Dehydrogenase (B-Specific).	J Histochem Cytochem 2008 Sep;56(9):853-61
PAP15 protein, Arabidopsis	EC 3.1.3.-	Acid Phosphatase Multienzyme Complexes *Arabidopsis Proteins 6-Phytase.	Plant Mol Biol 2005 Nov;59(4):581-94
IRE1 protein, Xenopus	0	Multienzyme Complexes Ribonucleases *Protein-Serine-Threonine Kinases Membrane Proteins.	Mech Dev 2008 Mar-Apr;125(3-4):207-22
IspD protein, E coli	EC 1.1.1.267	Multienzyme Complexes Oxidoreductases Aldose-Ketose Isomerases Escherichia coli Proteins.	J Org Chem. 2006 Nov 10;71(23):8824-34
GlmU protein, E coli	0	Multienzyme Complexes Escherichia coli Proteins.	Nucleic Acids Res 2007;35(8):2494-502
MUM4 protein, Arabidopsis	0	Multienzyme Complexes Arabidopsis Proteins Alcohol Oxidoreductases Carbohydrate Epimerases Hydro-Lyases.	J Biol Chem 2007 Feb 23;282(8):5389-403
phenylacetaldehyde synthase, Pentunia hybrida	0	*Multienzyme Complexes.	J Biol Chem 2006 Aug 18;281(33):23357-66
aflatoxin-detoxifizyme, Armillariella tabescens	0	*Multienzyme Complexes.	Food Chem Toxicol 1998 Jul;36(7):563-74
arsenate reductase 2, Arabidopsis	EC 1.-	Multienzyme Complexes Oxidoreductases cdc25 Phosphatases Arabidopsis Proteins.	Proc Natl Acad Sci U S A 2006 Apr 4;103(14):5413-8
MFE-1 protein, rat	0	*Multienzyme Complexes.	J Mol Biol 2006 Jan 27;355(4):734-46
prex protein, Plasmodium falciparum	0	Multienzyme Complexes Protozoan Proteins.	Mol Biochem Parasitol 2005 Jun;141(2):145-153
MASA enzyme, human	0	*Multienzyme Complexes.	J Mol Biol 2005 May 13;348(4):917-26
folC protein, E coli	EC 6.3.2.-	Multienzyme Complexes Peptide Synthases *Escherichia coli Proteins.
Dfp protein, E coli	0	Carboxy-Lyases Multienzyme Complexes Peptide Synthases Escherichia coli Proteins.
Dna2 protein, C elegans	0	DNA Helicases Endodeoxyribonucleases *Caenorhabditis elegans Proteins Multienzyme Complexes.	Nucleic Acids Res 2005;33(4):1372-83
Fol1 protein, S cerevisiae	0	Aldehyde-Lyases Dihydropteroate Synthase Multienzyme Complexes Diphosphotransferases.	Mol Biol Cell 2004 Aug;15(8):3811-28
Ggps1 protein, mouse	0	Multienzyme Complexes Farnesyltranstransferase.
Ftcd protein, mouse	0	*Multienzyme Complexes.
ade3 protein, Drosophila	0	Multienzyme Complexes Drosophila Proteins.
Arg5,6 protein, S cerevisiae	0	Aldehyde Oxidoreductases Multienzyme Complexes *Phosphotransferases (Carboxyl Group Acceptor) DNA-Binding Proteins.	Science 2004 Oct 15;306(5695):482-4
Nth1 protein, S pombe	0	Multienzyme Complexes Schizosaccharomyces pombe Proteins DNA-(Apurinic or Apyrimidinic Site) Lyase DNA Glycosylases DNA Repair.	Nucleic Acids Res 2004;32(17):5119-25
Hsd17b4 protein, mouse	EC 1.1.1.-	Enoyl-CoA Hydratase Multienzyme Complexes *17-Hydroxysteroid Dehydrogenases.
Hsd17b4 protein, rat	EC 1.1.1.-	Enoyl-CoA Hydratase Multienzyme Complexes *17-Hydroxysteroid Dehydrogenases.
NEC3 protein, Nicotiana tabacum	0	Carbonic Anhydrases Multienzyme Complexes NADH, NADPH Oxidoreductases Plant Proteins.	Plant Mol Biol 2004 Feb;54(3):415-25
FabZ protein, Enterococcus faecalis	0	Bacterial Proteins Multienzyme Complexes Hydro-Lyases cis-trans-Isomerases.	J Biol Chem 2004 Aug 13;279(33):34489-95
rcsC protein, E coli	0	Multienzyme Complexes Phosphoprotein Phosphatases Protein Kinases Escherichia coli Proteins Transcription Factors Bacterial Capsules.
Des2 protein, mouse	EC 1.-	Multienzyme Complexes Oxidoreductases.	J Biol Chem 2002 Jul 12;277(28):25512-8
MnmC protein, E coli	0	Multienzyme Complexes Escherichia coli Proteins.	RNA 2004 Aug;10(8):1236-42
ArsAB ATPase, E Coli	EC 3.6.3.16	Ion Pumps Multienzyme Complexes *Escherichia coli Proteins.	J Biol Chem. 2004 Apr 30;279(18):18334-341
UDP-N-acetylglucosamine 2-epimerase - N-acetylmannosamine kinase	0	*Multienzyme Complexes.	Neurology 2003 Aug 12;61(3):384-6
biphenyl synthase, Sorbus aucuparia	0	*Multienzyme Complexes.	Planta 2004 Jan;218(3):492-6
lovA protein, Aspergillus terreus	0	Fungal Proteins Multienzyme Complexes Aspergillus.	Org Biomol Chem. 2003 Jan 7;1(1):50-9
cellulosome, Clostridium	0	Cellulase Multienzyme Complexes Cellulose.	Chem Rec 2001;1(1):24-32
yellow f2 protein, Drosophila	0	Carboxy-Lyases Isomerases *Multienzyme Complexes Drosophila Proteins.	Biochem J 2002 Nov;368(Pt 1):333-40
yellow f protein, Drosophila	0	Carboxy-Lyases Isomerases *Multienzyme Complexes Drosophila Proteins.	Biochem J 2002 Nov;368(Pt 1):333-40
3-hydroxykynurenine transaminase-alanine glyoxylate transaminase, Aedes aegypti	0	Transaminases Multienzyme Complexes.	FEBS Lett 2002 Sep 11;527(1-3):199-204
YfcX protein, E coli	0	Multienzyme Complexes Escherichia coli Proteins Alcohol Oxidoreductases Enoyl-CoA Hydratase.	J Bacteriol 2002 Oct;184(20):5696-705
thioredoxin glutathione reductase	EC 1.6.4.-	Multienzyme Complexes NADH, NADPH Oxidoreductases.	Mol Biochem Parasitol 2002 Apr 30;121(1):129-39
peroxisomal multifunctional protein, Oryza sativa	0	Multienzyme Complexes Plant Proteins *RNA-Binding Proteins Microtubule-Associated Proteins.	J Biol Chem 2002 Jan 25;277(4):2385-952419-29
indolepyruvate - methylviologen oxidoreductase	0	Carboxy-Lyases Multienzyme Complexes *Oxidoreductases.	FEBS Lett 2002 Jan 16;510(3):196-200
D,D heptose 7-phosphate kinase-D,D-heptose 1-phosphate adenylyltransferase, E coli	EC 3.1.3.-	Multienzyme Complexes Nucleotidyltransferases *Phosphotransferases (Alcohol Group Acceptor).	J Bacteriol 2002 Jan;184(2):363-9
rtxA protein, Bradyrhizobium elkanii	EC 2.6.1.-	Transaminases Bacterial Proteins *Multienzyme Complexes.	Appl Environ Microbiol 2001 Nov;67(11):4999-5009
GrdD protein, Eubacterium acidaminophilum	EC 1.4.1.-	Amino Acid Oxidoreductases Multienzyme Complexes.	Eur J Biochem 2001 Dec;268(24):6417-25
lovC protein, Aspergillus terreus	0	Fungal Proteins Multienzyme Complexes.	Bioorg Med Chem Lett 2001 Jun 18;11(12):1527-31
TaK protein, Myxococcus xanthus	0	Bacterial Proteins Multienzyme Complexes.	FEMS Microbiol Lett 2001 Sep 25;203(2):191-7
Senp2 protein, mouse	0	*Multienzyme Complexes.	J Biol Chem 2001 Oct 19;276(42):39060-6
3-dehydroquinate dehydratase-shikimate - NADP oxidoreductase	0	Alcohol Oxidoreductases Hydro-Lyases *Multienzyme Complexes.	Plant Physiol 2001 APr;125(4):1891-900
carboxypeptidase-aminoacylase PP	EC 3.-	Amidohydrolases Carboxypeptidases *Multienzyme Complexes.	Appl Environ Microbiol 2001 Feb;67(2):673-9
41 kDa collagenase-gelatinase	EC 3.4.24.-	Multienzyme Complexes Collagenases *Gelatinases.	Zygote 2000;8 Suppl 1:S37-40

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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