Myelodysplastic Syndromes (definition)

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ψ	Myelodysplastic Syndromes

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Definition: Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.

myelo- here
Examples Anemia, Refractory; Anemia, Sideroblastic; Hemoglobinuria, Paroxysmal

Other names Dysmyelopoietic Syndromes; Syndromes, Myelodysplastic; Syndromes, Dysmyelopoietic; Syndrome, Myelodysplastic; Syndrome, Dysmyelopoietic; Myelodysplastic Syndrome; Myelodysplasias, Hematopoetic; Myelodysplasia, Hematopoetic; Hematopoetic Myelodysplasias; Dysmyelopoietic Syndrome; Hematopoetic Myelodysplasia

Substance	CAS Registry & name	Categories	Source
MDS2 protein, human	0	*Proteins Myelodysplastic Syndromes.	Genes Chromosomes Cancer 2002 Sep;35(1):11-9
decitabine	2353-33-5	Azacitidine/analogs & derivatives Myelodysplastic Syndromes DNA Modification Methylases/antagonists & inhibitors. Pharma Action* Antimetabolites, Antineoplastic ; Enzyme Inhibitors ; Teratogens	Biochem Pharmacol 28(8):1443;1979; Cancer Res 1979;39(10):3822; Cancer Res 37:1636;1977; Cancer Res 38(9):2673;1978; FEBS Lett 78(2):244;1977; JNCI 1979;63(4):1035; Neoplasma 25(4):385;1978	DACOGEN

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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