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NADH, NADPH Oxidoreductases

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Definition: A group of oxidoreductases that act on NADH or NADPH. In general, enzymes using NADH or NADPH to reduce a substrate are classified according to the reverse reaction, in which NAD+ or NADP+ is formally regarded as an acceptor. This subclass includes only those enzymes in which some other redox carrier is the acceptor. (Enzyme Nomenclature, 1992, p100) EC 1.6.     
Examples Apoptosis Inducing Factor; Cytochrome Reductases; Electron Transport Complex I; NADH Tetrazolium Reductase; NADP Transhydrogenases; NADPH Dehydrogenase; NADPH Oxidase; Quinone Reductases 		Other names Oxidoreductases, NADH, NADPH; Oxidoreductases NADH, NADPH; NADPH Oxidoreductases NADH
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
NDC1 protein, Arabidopsis  EC 1.6.-   *NADH, NADPH Oxidoreductases *Arabidopsis Proteins. Proc Natl Acad Sci U S A 2011 Aug 23;108(34):14354-9
YqjH protein, E coli  EC 1.6.99.-   *NADH, NADPH Oxidoreductases *Escherichia coli Proteins. Acta Crystallogr Sect F Struct Biol Cryst Commun 2008 Sep 1;64(Pt 9):792-6
NDUFB6 protein, rat  EC 1.6.5.3   *NADH, NADPH Oxidoreductases. J Nutrigenet Nutrigenomics. 2009;2(6):267-72
YMR315w protein, S cerevisiae  EC 1.6.-   *NADH, NADPH Oxidoreductases *Saccharomyces cerevisiae Proteins. N Biotechnol 2009 Oct 31;26(3-4):171-80
MDAR2 protein, Arabidopsis  EC 1.6.-   *NADH, NADPH Oxidoreductases *Arabidopsis Proteins. J Plant Physiol 2009 Aug 15;166(12):1263-74
NADPH-coenzyme Q reductase, rat  EC 1.6.99.-   *NADH, NADPH Oxidoreductases. Biofactors 2008;32(1-4):59-70
NDUFB6 protein, human  EC 1.6.5.3   *NADH, NADPH Oxidoreductases. J Clin Invest. 2007 Nov;117(11):3427-35
monodehydroascorbate reductase 4, Arabidopsis  EC 1.6.-   *NADH, NADPH Oxidoreductases. Plant Cell 2007 Apr;19(4):1376-87
coenzyme A disulfide reductase, Staphylococcus aureus  EC 1.6.4.10   *NADH, NADPH Oxidoreductases. J Biol Chem 1998 Mar 6;273(10):5744-51
anthocyanidin reductase, Ginkgo biloba  EC 1.3.1.77   *NADH, NADPH Oxidoreductases. J Plant Physiol 2006 Feb;163(2):224-7
ytfG protein, E coli  EC 1.6.99.-   *NADH, NADPH Oxidoreductases *Escherichia coli Proteins. Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):365-7
RbohA protein, Solanum tuberosum  EC 1.6.1.-   *NADH, NADPH Oxidoreductases *Plant Proteins.
NEC3 protein, Nicotiana tabacum  0   *Carbonic Anhydrases *Multienzyme Complexes *NADH, NADPH Oxidoreductases *Plant Proteins. Plant Mol Biol 2004 Feb;54(3):415-25
Grim19 protein, mouse  EC 1.6.5.-   *NADH, NADPH Oxidoreductases Apoptosis Protein Subunits.
thioredoxin glutathione reductase  EC 1.6.4.-   *Multienzyme Complexes *NADH, NADPH Oxidoreductases. Mol Biochem Parasitol 2002 Apr 30;121(1):129-39
FprA protein, M tuberculosis  EC 1.18.1.-   *NADH, NADPH Oxidoreductases. Biochemistry 2002 Jul 16;441(28):8807-18
FLBR-2 protein, Glycine max  EC 1.6.-   *NADH, NADPH Oxidoreductases *Soybean Proteins. Plant Physiol 2002 Jan;128(1):300-13
dimethylsulfone reductase  EC 1.8.1.-   *NADH, NADPH Oxidoreductases Arthrobacter Hyphomicrobium. Arch Microbiol 2002 Feb;177(2):173-83
YNR074C protein, S cerevisiae  EC 1.6.-   *NADH, NADPH Oxidoreductases *Saccharomyces cerevisiae Proteins. Curr Genet 2001 May;39(3):127-36
GRIM19 protein, human  EC 1.6.5.-   *NADH, NADPH Oxidoreductases *Apoptosis Regulatory Proteins Apoptosis Protein Subunits. J Biol Chem 2001 Oct 19;276(42):38345-8
NUBM protein, Yarrowia lipolytica  EC 1.6.99.3   *Fungal Proteins *NADH, NADPH Oxidoreductases. Folia Microbiol (Praha) 2000;45(5):429-33
SfrA protein, Geobacter sulfurreducens  EC 1.6.99.-   *Bacterial Proteins *NADH, NADPH Oxidoreductases. J Bacteriol 2001 Aug;183(15):4468-76
tumor-associated NADH oxidase  EC 1.6.-   *NADH, NADPH Oxidoreductases Neoplasm Proteins. Arch Biochem Biophys 2001 Jul 15;391(2):149-59
protein disulfide oxidoreductase, Methanococcus jannaschii  EC 1.6.4.-   *NADH, NADPH Oxidoreductases. Protein Sci 2001 Feb;10(2):384-96
EmoB protein, bacterium BNC1  EC 1.6.99.-   *Bacterial Proteins *NADH, NADPH Oxidoreductases. Appl Environ Microbiol 2001 Feb;67(2):688-95
NAD phosphite oxidoreductase  EC 1.6.99.-   *NADH, NADPH Oxidoreductases. J Biol Chem 2001 May 18;276(20):17429-36
CNOX protein, human  EC 1.6.-   *NADH, NADPH Oxidoreductases. Arch Biochem Biophys 2001 Feb 1;386(1):106-16
artificial mediator accepting pyridine nucleotide oxidoreductase  EC 1.6.99.-   *NADH, NADPH Oxidoreductases. J Biotechnol 2000 Oct 13;83(3):253-67
NADH peroxiredoxin oxidoreductase  EC 1.6.8.-   *Flavoproteins *NADH, NADPH Oxidoreductases. Eur J Biochem 2000 Oct;267(20):6126-33
PrxR protein, Thermus aquaticus  EC 1.6.4.-   *Bacterial Proteins *NADH, NADPH Oxidoreductases Flavoproteins. J Biol Chem 2000 Sep 29;275(39):30019-28
renal NAD(P)H oxidase  EC 1.6.-   *NADH, NADPH Oxidoreductases. Proc Natl Acad Sci U S A 2000 Jul 5;97(14):8010-4
NDUFB7 protein, human  EC 1.6.5.3   *NADH, NADPH Oxidoreductases. Biochem Biophys Res Commun 1990;166(2):984; Hum Genet 2000 Apr;106(4):385-91
cytochrome P450 reductase, Aspergillus niger  EC 1.6.2.-   *Fungal Proteins NADH, NADPH Oxidoreductases.
BANYULS protein, Arabidopsis  EC 1.6.-   *NADH, NADPH Oxidoreductases *Arabidopsis Proteins Biological Markers Leucine Zippers Proanthocyanidins. Plant J 1999 Aug;19(4):387-98
Nox-2 protein, bacteria  EC 1.6.99.-   *Bacterial Proteins *NADH, NADPH Oxidoreductases. J Bacteriol 1999 Oct;181(19):5940-7
NADPH oxidase 1  EC 1.6.99.-   *NADH, NADPH Oxidoreductases. J Bacteriol 1999 Oct;181(19):5940-7
NfrA1 protein, Bacillus subtilis  EC 1.7.99.-   *Bacterial Proteins *Nitroreductases NADH, NADPH Oxidoreductases. Biosci Biotechnol Biochem 1998 Oct;62(10):1978-87
flavodoxin NADPH oxidoreductase  EC 1.6.-   *NADH, NADPH Oxidoreductases. Eur J Biochem 1998 Nov 1;257(3):577-85
protein disulfide oxidoreductase, P. furiosus  EC 1.6.4.-   *NADH, NADPH Oxidoreductases. Nat Struct Biol 1998 Jul;5(7):602-11
F420-dependent NADP reductase  EC 1.6.8.-   *NADH, NADPH Oxidoreductases. Arch Microbiol 1997 Nov;168(5):396-402
NADH-dichlorophenol-indophenol oxidoreductase  EC 1.6.-   *NADH, NADPH Oxidoreductases Membrane Proteins. Biochem J 1997 Jun 1;324( Pt 2):555-63
2-oxo-delta(3)-4,5,5--trimethylcyclopentenyl acetyl-CoA monooxygenase  EC 1.14.13.-   *NADH, NADPH Oxidoreductases. Bioorg Med Chem 1997 Feb;5(2):253-61
NADH-hypothiocyanite oxidoreductase  EC 1.6.99.-   *NADH, NADPH Oxidoreductases. Biochem Mol Med 1996 Apr;57(2):134-8
RbohA protein, Oryza sativa  EC 1.6.1.-   *NADH, NADPH Oxidoreductases *Plant Proteins. Plant J 1996 Sep;10(3):515-22
pyridine nucleotide-disulfide oxidoreductase ORF3  EC 1.8.1.-   *NADH, NADPH Oxidoreductases. J Bacteriol 1996 Nov;178(22):6644-6
Nqrf protein, Vibrio alginolyticus  EC 1.6.5.-   *Bacterial Proteins *Flavoproteins *NADH, NADPH Oxidoreductases. Biochem Soc Trans 1996 Feb;24(1):12S
MocA protein, Rhizobium meliloti  EC 1.-   *Bacterial Proteins NADH, NADPH Oxidoreductases Plant Proteins. Mol Gen Genet 1994 Oct 17:245(1):11-24
disulfide reductase, mycothiol  EC 1.6.4.-   *NADH, NADPH Oxidoreductases. Eur J Biochem 1994 Aug 15;224(1):203-13
NASC protein, Klebsiella oxytoca  EC 1.6.-   *Bacterial Proteins *NADH, NADPH Oxidoreductases. J Bacteriol 1994 May;176(9):2551-9
paraquat diaphorase  EC 1.6.4.-   *NADH, NADPH Oxidoreductases. Proc Natl Acad Sci U S A 1994 Feb 15;91(4):1328-31
baiH protein, Eubacterium  EC 1.6.-   *Bacterial Proteins *NADH, NADPH Oxidoreductases. J Bacteriol 1993 May;175(10):3002-12
delta-(alpha-aminoadipyl)cysteinylvalinedisulfide reductase  EC 1.6.4.-   *NADH, NADPH Oxidoreductases. J Bacteriol 1993 Feb;175(3):623-9
cob(II)yrinic acid a,c-diamide reductase  EC 1.6.99.-   *NADH, NADPH Oxidoreductases. J Bacteriol 1992 Nov;174(22):7452-4
ferripyoverdine reductase  EC 1.6.8.-   *NADH, NADPH Oxidoreductases. Eur J Biochem 1992 Oct 15;209(2):613-20
hmp protein, E coli  EC 1.6.99.7   *Dihydropteridine Reductase *Hemeproteins *NADH, NADPH Oxidoreductases *Escherichia coli Proteins. Biochem Biophys Res Commun 1992 Aug 31;187(1):94-100
L-canaline reductase  EC 1.6.6.-   *NADH, NADPH Oxidoreductases. Proc Natl Acad Sci USA 1992 Mar 1;89(5):1780-4
NAD(P)H plastoquinone oxidoreductase  EC 1.6.99.-   *NADH, NADPH Oxidoreductases. Plant Mol Biol 1992;18(1):135
NADH-cytochrome P-450 reductase  EC 1.6.2.-   *NADH, NADPH Oxidoreductases. Biochim Biophys Acta 1991;1084(1):35
aquacobalamin reductase  EC 1.6.99.8   *NADH, NADPH Oxidoreductases. J Nutr Sci Vitaminol (Tokyo) 1990;36(4):349
2,2'-dithiodiethanesulfonate reductase (NAD(P)H)  EC 1.6.4.-   *NADH, NADPH Oxidoreductases. J Bacteriol 1990;172(11):6435
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