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Naphthols

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Definition: Naphthalene derivatives carrying one or more hydroxyl (-OH) groups at any ring position. They are often used in dyes and pigments, as antioxidants for rubber, fats, and oils, as insecticides, in pharmaceuticals, and in numerous other applications.      Other names Hydroxynaphthalenes
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-methyl-1-naphthol  0   *Naphthols. J Phys Chem B. 2011 Oct 27;115(42):11971-83
2,3-naphthalenediol  0   *Naphthols. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Dec;83(1):540-52
6-(4-hydroxy-3-(trifluoromethyl)phenyl)-1-naphthol  0   *Naphthols *Phenols 17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. J Med Chem. 2011 Nov 10;54(21):7547-57.
dyngo-4a  0   *Hydrazones *Naphthols Dynamins/antagonists & inhibitors. J Biol Chem. 2011 Oct 14;286(41):35966-76.
1,2,3,4-tetrahydro-1-naphthalenol  0   *Naphthols. Eur J Med Chem. 2011 May;46(5):1545-54
(5-(3-methyl-4-(trifluoromethyl)phenyl)oxazol-2-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol  0   *Naphthols. Bioorg Med Chem. 2010 Jul 1;18(13):4821-9
5-chloro-6-(2-(4-cyanophenylamino)pyrimidin-4-yloxy)-7-methoxy-2-naphthonitrile  0   *Naphthols *Pyrimidines. Bioorg Med Chem. 2010 Jul 1;18(13):4601-5
6-(2-(4-cyanophenylamino)pyrimidin-4-yloxy)-5,7-dimethoxy-2-naphthonitrile  0   *Naphthols *Pyrimidines. Bioorg Med Chem. 2010 Jul 1;18(13):4601-5
Naphthol Blue Black  0   *Azo Compounds *Naphthols Coloring Agents. Appl Biochem Biotechnol. 2011 Feb;163(3):433-43
2,8-dihydroxy-3,4-dihydronaphthalen-1(2H)-one  0   *Naphthols. Zhong Yao Cai. 2009 Dec;32(12):1843-5
isoabienol  0   *Diterpenes *Naphthols Oils, Volatile. Nat Prod Commun. 2011 Feb;6(2):277-80
2-hydroxyphenyl-azo-2'-naphthol, Co(II) complex  0   *Naphthols *Organometallic Compounds Cobalt. Chem Biol Interact. 2011 Feb 1;189(3):206-14
5-fluoro-3-(4-phenylpiperidin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-ol  0   *Naphthols *Piperidines Fluorine Radioisotopes. Bioorg Med Chem 2010 Nov 1;18(21):7659-67
1-hydroxy-2-naphthaldehyde  0   *Naphthols. J Phys Chem B 2010 Oct 7;114(39):12528-40
4-(3-(methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol  0   *Naphthols *Pyrrolidines Norepinephrine Plasma Membrane Transport Proteins/antagonists & inhibitors Histamine H3 Antagonists. J Med Chem 2010 Nov 11;53(21):7869-73
JGB 1741  0   *Naphthols *Thiophenes. Biochem Biophys Res Commun 2010 Oct 8;401(1):13-9
5-(6-hydroxy-2-naphthyl)-1,2,3-benzenetriol  0   *Naphthols Pyrogallol/*analogs & derivatives Monophenol Monooxygenase/antagonists & inhibitors. Bioorg Med Chem Lett 2010 Aug 15;20(16):4882-4
para red  0   *Azo Compounds *Naphthols. J AOAC Int 2007 Mar-Apr;90(2):437-45
N-tylosil-1-amino-(3-bromophenyl)methyl-2-naphthol  0   *Lactones *Naphthols. Br J Cancer 2010 Jul 13;103(2):178-85
isoplumbagolone  0   *Naphthols. Bioorg Med Chem Lett 2010 May 1;20(9):2974-7
Nb-(alpha-hydroxynaphthoyl)serotonin  0   *Naphthols Serotonin/*analogs & derivatives Janus Kinase 3/antagonists & inhibitors. Br J Haematol 2010 Jan;148(1):132-43
1,1-methylene-di-(2-naphthol)-3-acetyloxy-4-trimethylammonio-butanoate  0   *Naphthols gamma-Aminobutyric Acid/*analogs & derivatives. Arch Virol 2009;154(9):1539-44
1-(alpha-aminobenzyl)-2-naphthol  0   *Naphthols. Chemistry. 2009 Jul 6;15(27); 6718-22
IPA-3 compound  0   *Disulfides *Naphthols. Chem Biol 2008 Apr;15(4):322-31
2-hydroxy-3-naphthoic acid  0   *Naphthols. J Colloid Interface Sci 2009 May 1;333(1):85-96
6-(3-hydroxyphenyl)-2-naphthol  0   *Naphthols. Arch Pharm Res 2009 Feb;32(2):289-94
1,3-diphenyl-1,2,3,4-tetrahydro-1-naphthol  0   *Naphthols *Tetrahydronaphthalenes. Acta Crystallogr C 2009 Feb;65(Pt 2):o35-8
N-(3-((2-hydroxynaphthalen-1-ylmethylene)amino)phenyl)-2-phenylpropionamide  0   *Naphthols *Phenylpropionates. Oncogene 2009 Feb 12;28(6):781-91
Art1 compound  0   *Naphthols. Biosci Biotechnol Biochem 2008 Oct;72(10):2521-5
1-hydroxy-5,7-dimethoxy-2-naphthalenecarboxaldehyde  0   *Naphthols. Cancer Res 2008 Oct 15;68(20):8573-81
4-(ethoxycarbonylmethoxy)-1-hydroxy-2-naphthoic acid  0   *Naphthols Caspase 3/antagonists & inhibitors. Bioorg Med Chem 2008 May 1;16(9):4854-9
naphthalecin  0   *Naphthols. J Antibiot (Tokyo) 2008 Apr;61(4):207-12
2-((1-(hydroxymethyl)cyclohexyl)methyl)naphthalen-1-ol  0   *Naphthols. Biosci Biotechnol Biochem 2008 Apr;72(4):1023-31
eleutherinol  0   *Naphthols *Pyrones. Biochem Biophys Res Commun 2008 Jun 27;371(2):278-82
epoxymollugin  0   *Naphthols *Pyrans. Chem Pharm Bull (Tokyo) 2008 Feb;56(2):213-6
6-((2-(4-phenylpiperazin-1-yl)ethyl)(propyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol  0   *Naphthols *Piperazines Receptors, Dopamine D3/agonists. J Med Chem 2008 Jan 10;51(1):101-17
3-acetyl-2-methyl-1,4,5-trihydroxy-2,3-epoxynaphthoquinol  0   *Epoxy Compounds *Naphthols. Phytochemistry 2007 Oct;68(19):2444-9
1-(phenylazophenylazo)-2-naphthol  0   *Azo Compounds *Naphthols. J Cosmet Sci 2007 May-Jun;58(3):255-66
bis(1'-hydroxy-2'-acetonaphthone)-2,2'-diiminodiethylamine  0   *Imines *Naphthols. Ann Chim 2007 Aug;97(8):747-57
1-cyclohexyl-4-(3-(6-hydroxynaphthalen-1-yl)propyl)piperazine  0   *Naphthols *Piperazines Ligands. J Med Chem 2007 Sep 20;50(19):4648-55
4-(6-hydroxy-2-naphthyl)-1,3-benzenediol  0   *Naphthols *Resorcinols. Biol Pharm Bull 2007 Sep;30(9):1711-5
naphthalene-1,6-diol  0   *Naphthols. Acta Crystallogr C 2007 Jul;63(Pt 7):o419-22
1,3,8-trihydroxynaphthalene  0   *Naphthols. J Phys Chem B 2007 Jul 19;111(28):8314-20
naphthalene-1,7-diol  0   *Naphthols. Acta Crystallogr C 2007 Apr;63(Pt 4):o252-4
2-phenyliminomethyl-naphthalen-1-ol  0   *Naphthols. J Phys Chem B Condens Matter Mater Surf Interfaces Biophys 2006 Dec 14;110(49):25026-32
7-bromo-3-hydroxy-2-naphth-2-hydroxyanilide  0   *Anilides *Naphthols. J Org Chem 2006 Mar 3;71(5):1769-76
germacradienol  0   *Naphthols. J Antibiot (Tokyo). 2006 Aug;59(8):471-9
peribysin H  0   *Furans *Naphthols. J Antibiot (Tokyo). 2006 Jun;59(6):345-50
peribysin I  0   *Naphthols *Furans. J Antibiot (Tokyo). 2006 Jun;59(6):345-50
5,5',6,6',7,7',8,8'-octahydro-1,1'-bi-2-naphthol  0   *Naphthols. J Sep Sci 2005 Nov;28(17):2282-7
1-(4,6-dimethylpyrimidin-2-ylazo)naphthalen-2-ol  0   *Azo Compounds *Naphthols Ligands. Spectrochim Acta A Mol Biomol Spectrosc 2005 Nov;62(1-3):694-702
2'-N-alpha-methylbenzylcarbamyl-1, 1'-bi-2-naphthol  0   *Naphthols. BMC Biochem 2005;6(dup#1):17
2,6-dihydroxynaphthalene-1-carboxaldehyde 6-phosphate  0   *Naphthols *Phosphoric Acid Esters Fructose-Bisphosphate Aldolase/antagonists & inhibitors. J Med Chem 2006 Mar 9;49(5):1499-502
1,4-dipropyl-2,3-naphthalenediol  0   *Naphthols. Free Radic Biol Med 2005 Nov 15;39(10):1368-77
4,8-dihydroxy-3-O-(glucopyranosyl)hydroxymethyl-4-methyl-1,2,3,4-tetrahydronaphthalene-1-one  0   *Glucosides *Naphthols. J Antibiot (Tokyo) 2005 Dec;58(12):822-7
4,8-dihydroxy-3-hydroxymethyl-4-methyl-1,4-dihydronaphthalene-1-one  0   *Naphthols. J Antibiot (Tokyo) 2005 Dec;58(12):822-7
4,8-dihydroxy-3-hydroxymethyl-4-methyl-1,2,3,4-tetrahydronaphthalene-1-one  0   *Naphthols. J Antibiot (Tokyo) 2005 Dec;58(12):822-7
ethyl 4-((2-hydroxy-1-naphthyl)azo)benzoate  0   *Azo Compounds *Naphthols. Eur J Drug Metab Pharmacokinet 2005 Jan-Jun;30(1-2):91-7
3-(3-fluoro-4-hydroxyphenyl)-7-hydroxy-1-naphthonitrile  0   *Naphthols Estrogen Receptor beta/agonists. J Med Chem 2005 Jun 16;48(12):3953-79
peribysin G  0   *Naphthols. J Antibiot (Tokyo) 2005 Mar;58(3):185-91
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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