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Naphthoquinones

More information in Books or onNLM PubMed
Definition: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.     
Examples Vitamin K 		Other names Naphthazarins; Naphthalenediones
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-methyl-7-hydroxymethyl-1,4-naphthoquinone  0   *Naphthoquinones AMP-Activated Protein Kinases/drug effects. Fitoterapia. 2011 Dec;82(8):1285-9
alteronol  0   *Naphthoquinones. J Pharm Pharmacol. 2012 Jan;64(1):101-7.
6'-O-acetylisobiflorin  0   *Naphthoquinones Antioxidants. Biosci Biotechnol Biochem. 2011;75(11):2207-12
JBIR-85  0   *Polyketides *Naphthoquinones. J Nat Prod. 2011 Dec 27;74(12):2588-91
3-(3-chloro-1,4-naphthoquinon-2-yl)-2-methylpropenoic acid  0   *Methacrylates *Naphthoquinones. J Med Chem. 2010 Feb 11;53(3):1200-10.
LQB 118  0   *Naphthoquinones *Pterocarpans. J Antimicrob Chemother. 2011 Jul;66(7):1555-9.
LAB 027  0   *Naphthoquinones *Organometallic Compounds Tellurium. Cell Death Dis. 2011;2:e191.
ascomycone C  0   *Naphthoquinones. J Nat Prod. 2008 Nov;71(11):1973-6
ascomycone B  0   *Naphthoquinones *Pyrans. J Nat Prod. 2008 Nov;71(11):1973-6
ascomycone A  0   *Naphthoquinones *Pyrans. J Nat Prod. 2008 Nov;71(11):1973-6
A80915B  0   *Naphthoquinones Methicillin-Resistant Staphylococcus aureus/drug effects. Mar Drugs. 2011;9(4):680-9
2-decylamino-5,8-dimethoxy-1,4-naphthoquinone  0   *Naphthoquinones. Biochem Biophys Res Commun 2011 Jul 22;411(1):213-8
3-(2-(dimethylamino)ethylamino)-N-(4,9-dioxo-4,9-dihydronaphtho(2,3-b)thiophen-3-yl)propanamide  0   *Naphthoquinones *Thiophenes DNA Topoisomerases, Type II Topoisomerase Inhibitors. J Med Chem 2011 Jun 23;54(12):
3-(diethylamino)-N-(4,9-dioxo-4,9-dihydronaphtho(2,3-b)thiophen-3-yl)propanamide  0   *Naphthoquinones *Thiophenes DNA Topoisomerases, Type II Topoisomerase Inhibitors. J Med Chem 2011 Jun 23;54(12):4077-91
3-(2-(dimethylamino)isopropoxy)-1-hydroxybenzo(b)naphtho(2,3-d)furan-6,11-dione  0   *Benzofurans *Naphthoquinones. Chem Biol Interact 2011 Aug 15;193(1):43-9
2-carbomethoxy-2,3-epoxy-3-prenyl-1,4-naphthoquinone  0   *Naphthoquinones. J Med Food. 2011 May;14(5):454-61
furaquinocin I  0   *Naphthoquinones. J Antibiot (Tokyo). 2011 Jul;64(7):509-13
furaquinocin J  0   *Naphthoquinones. J Antibiot (Tokyo). 2011 Jul;64(7):509-13
12,13-dihydro-N-methyl-6,11,13-trioxo-5H-benzo(4,5)cyclohepta(1,2-b)naphthalen-5,12-imine  0   *Naphthoquinones DNA Topoisomerases, Type II DNA Topoisomerases, Type I Topoisomerase Inhibitors. Biochem Biophys Res Commun 2011 Apr 29;408(1):94-8
2-acetylamino-3-chloro-1,4-naphthoquinone  0   *Naphthoquinones. Br J Pharmacol. 2011 Apr;162(8):1871-83
landomycin P  0   *Naphthoquinones *Oligosaccharides. J Nat Prod. 2011 Jan 28;74(1):2-11
3-(((6-methoxy-10-methyl-1H,3H-benzo(h)furo(4,3,2-de)-2-benzopyran-1-yl)oxy)methyl)-5-methylnaphtho(2,3-b)furan-4,9-dione  0   *Benzofurans *Naphthoquinones. J Med Food 2011 Jan-Feb;14(1-2):120-7
tigloylshikonin  0   *Naphthoquinones. Chem Pharm Bull (Tokyo). 2011;59(1):117-9
2-bromo-3-methyl-1,4-naphthoquinone  0   *Naphthoquinones. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7226-9
4-bromohamigeran B  0   *Naphthoquinones. Org Lett. 2011 Jan 21;13(2):347-9
furano-1,2-naphthoquinone  0   *Furans *Naphthoquinones. Cell Biochem Funct 2010 Dec 2;28(8):695-705
6,6',7,7'-tetrahydroxy-3,3'-dimethyl-5,5'-bis(4-methylphenethyl)-2,2'-binaphthyl-1,1',4,4'-tetraone  0   *Naphthoquinones Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors. J Med Chem 2010 Nov 25;53(22):8000-11
fluostatin H  0   *Fluorenes *Naphthoquinones. J Am Chem Soc 2010 Sep 1;132(34):11902-3
fluostatin G  0   *Fluorenes *Naphthoquinones. J Am Chem Soc 2010 Sep 1;132(34):11902-3
fluostatin F  0   *Fluorenes *Naphthoquinones. J Am Chem Soc 2010 Sep 1;132(34):11902-3
aggregatin D  0   *Naphthoquinones. Nat Prod. 2010 Aug 27;73(8):1434-7
eleuthinone A  0   *Naphthoquinones. Planta Med 2010 Mar;76(4):345-9
flaviogeranin  0   *Naphthoquinones. J Antibiot (Tokyo). 2010 Jul;63(7):379-80
chitranane  0   *Naphthoquinones. Bioorg Med Chem Lett 2010 May 1;20(9):2974-7
isovalerylshikonin  0   *Naphthoquinones *Pentanoic Acids. Biomed Chromatogr 2010 Apr;24(4):413-9
2-pyrrilidino-3-(p-hydroxyphenylamino)-1,4-naphthoquinone  0   *Naphthoquinones. Vascul Pharmacol. 2009 Oct;51(4):225-35
5-hydroxylapachol  0   *Naphthoquinones. Bioorg Med Chem. 2010 Apr 1;18(7):2621-30
arnebiabinone  0   *Naphthoquinones. J Asian Nat Prod Res. 2010 Apr;12(4):286-92
N-(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzamide  0   *Benzamides *Naphthoquinones. Anticancer Res 2010 Feb;30(2):519-27
2-chloro-3-(3-amino-4-methyl-phenylamino)-1,4-naphthoquinone  0   *Naphthoquinones. Br J Haematol. 2009 Nov;147(4):459-70
astropaquinone C  0   *Naphthoquinones. Planta Med. 2009 Oct;75(12):1339-43
astropaquinone B  0   *Naphthoquinones. Planta Med. 2009 Oct;75(12):1339-43
astropaquinone A  0   *Naphthoquinones. Planta Med. 2009 Oct;75(12):1339-43
beta-acetoxyisovalerylshikonin  0   *Naphthoquinones. J Sep Sci 2008 Mar;31(4):629-35
1,2-naphthoquinone-1-methide  0   *Naphthoquinones. J Am Chem Soc 2009 Aug 26;131(33):11892-9
2,3-naphthoquinone-3-methide  0   *Naphthoquinones. J Am Chem Soc 2009 Aug 26;131(33):11892-9
rhinacanthin-D  0   *Naphthoquinones. Phytomedicine. 2009 Oct;16(10):929-34
lindbladione  0   *Naphthoquinones. Bioorg Med Chem Lett 2009 Oct 1;19(19):5778-81
bothriodumin  0   *Naphthoquinones. Pharmazie. 2009 Sep;64(9):619-21
artemisinin-naphthoquine combination  0   *Naphthoquinones *Artemisinins. Malar J. 2009;8() (dup#82):196
2,5,6,7-tetrahydroxy-1,4-naphthoquinone  0   *Naphthoquinones. Chem Pharm Bull (Tokyo) 2009 Aug;57(8):894-5
2,3-diphenyl-1,4-naphthoquinone  0   *Naphthoquinones Dihydrolipoamide Dehydrogenase/antagonists & inhibitors. J Parasitol 2009 Apr;95(2):461-6
7,8-dihydroxy-1-methylnaphtho(2,3-c)furan-4,9-dione  0   *Furans *Naphthoquinones. J Nat Prod. 2009 Jun;72(6):1213-5
2-euryfuryl-1,4-naphthoquinone  0   *Naphthoquinones. Chem Pharm Bull (Tokyo) 2009 Jun;57(6):615-9
adociaquinone B  0   *Cyclic S-Oxides *Naphthoquinones. Bioorg Med Chem 2009 Mar 15;17(6):2276-81
2,2-dimethyl-3,4-dihydrospiro(benzo(g)chromene-10,2'-oxiran)-5(2H)-one  0   *Naphthoquinones. Parasitol Res 2006 Sep;99(4):429-33
bis-aziridinylnaphthoquinone  0   *Naphthoquinones. Acta Pharmacol Sin 2007 Apr;28(4):559-66
7-deoxykalafungin  0   *Naphthoquinones. J Org Chem 2009 Jan 2;74(1):423-6
7-deoxyfrenolicin B  0   *Naphthoquinones. J Org Chem 2009 Jan 2;74(1):423-6
2-propanoylamine-1,4-naphthoquinone  0   *Anilides *Naphthoquinones. J Exp Ther Oncol 2008;7(2):113-21
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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