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Neurotensin

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Definition: A biologically active tridecapeptide isolated from the hypothalamus. It has been shown to induce hypotension in the rat, to stimulate contraction of guinea pig ileum and rat uterus, and to cause relaxation of rat duodenum. There is also evidence that it acts as both a peripheral and a central nervous system neurotransmitter.  a neurotransmitter isolated from the hypothalamus; /biosyn /physiol permitted   
See Also Receptors, Neurotensin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N,N',N',N-tetrakis((N-(arginyl-arginyl-prolyl-tyrosyl-isoleucyl-leucine)aminocarbonyl)ethyl)-1,4,8,11-tetraazacyclotetradecane  0   *Heterocyclic Compounds, 1-Ring *Peptide Fragments Neurotensin/*analogs & derivatives Ligands. J Inorg Biochem 2011 Jun;105(6):821-32
neurotensin NT79  0   *Peptide Fragments Neurotensin/*analogs & derivatives. Brain Res. 2010 Jan 13;1308:35-46
KK13 peptide  0   *Oligopeptides Neurotensin/*analogs & derivatives. J Pharm Pharmacol. 2005 Mar;57(3):327-33
neurotensin (1-13)  0   *Peptide Fragments Neurotensin/*analogs & derivatives. Psychopharmacology (Berl). 2003 Jul;168(3):253-61
technetium Tc 99m NT-XI  0   *Organotechnetium Compounds Neurotensin/*analogs & derivatives. J Nucl Med 2003 Oct;44(10):1649-54
NT77, rat  0   Neurotensin/*analogs & derivatives. Life Sci. 2003 Oct 3;73(20):2611-23
stearyl-Nle(17)-neurotensin(6-11)VIP(7-28)  0   *Neurotensin *Vasoactive Intestinal Peptide. Cancer 2001 Oct 15;92(8):2172-80
proneurotensin  0   *Neurotensin *Protein Precursors. Mol Psychiatry 2000 Mar;5(2):208-12
neurotensin (9-13)  0   *Neurotensin *Peptide Fragments. Bioorg Med Chem Lett 2000 Mar 6;10(5):453-5
neurotensin (8-13), N-methyl-Arg(8)-Lys(9)-neo-Trp(11)-neo-Leu(12)  0   *Peptide Fragments Neurotensin/*analogs & derivatives. Eur J Pharmacol 2000 Feb 25;390(1-2):107-11
neurotensin 69L  0   *Peptide Fragments Neurotensin/*analogs & derivatives. Brain Res 2000 Feb 21;856(1-2):48-54
PD 149163  0   Neurotensin/*analogs & derivatives. J Pharmacol Exp Ther 1999 Feb;288(2):710-3
RP 66453, secondary peptide  0   *Peptides Neurotensin/antagonists & inhibitors. J Antibiot (Tokyo) 1998 May;51(5):512-4
TJN 950  0   *Peptide Fragments Neurotensin/*analogs & derivatives. FEBS Lett 1997 Dec 1;418(3):341-5
JMV 1193  0   *Peptide Fragments Neurotensin/*analogs & derivatives. Neurosci Lett 1996 Oct 11;217(1):58-60
neurotensin, N-alpha-(fluoresceinylthiocarbamyl)glutamyl(1)  0   *Fluoresceins Neurotensin/*analogs & derivatives. J Histochem Cytochem 1994 Jun;42(6):755-63
neurotensin (8-13), Asp(12)  0   *Peptide Fragments Neurotensin/*analogs & derivatives. Agents Actions 1993 Jan;38(1-2):1-7
neurotensin (8-13), Asp(13)  0   *Peptide Fragments Neurotensin/*analogs & derivatives. Agents Actions 1993 Jan;38(1-2):1-7
neurotensin (8-13), Lys(8)  0   *Peptide Fragments Neurotensin/*analogs & derivatives. J Pharmacol Exp Ther 1993 Jan;264(1):1-5
xenin 25  144092-28-4   *Neurotensin Gastrointestinal Hormones. J Biol Chem 1992 Nov 5;267(31):22305-9
(VIP-neurotensin) hybrid antagonist  125093-93-8   *Neurotensin *Vasoactive Intestinal Peptide Recombinant Fusion Proteins. J Pharmacol Exp Ther 1991;257(3):959
methyl(arginyl)-lysyl-prolyl-tryptophyl-tert-leucyl-leucine  0   *Oligopeptides Neurotensin. J Chromatogr 1990;534:190
neurotensin, Tyr(11)  64088-62-6   Neurotensin/*analogs & derivatives Stereoisomerism. Peptides 1990;11(6):1169
methylarginyl-lysyl-prolyl-tryptophyl-tert-leucyl-leucyl-ethyl ester  125600-60-4   *Oligopeptides Neurotensin. Chem Pharm Bull (Tokyo) 1990;38(11):3094
vasoactive intestinal peptide-neurotensin hybrid  0   *Neurotensin *Peptide Fragments *Vasoactive Intestinal Peptide. Endocrinology 1989;125(6):2945
neurotensin (1-11)  74032-89-6 Neurotensin (ox), 12-de-L-isoleucine-13-de-L-leucine  *Neurotensin *Peptide Fragments. Pancreas 1989;4(1):114
neurotensin (1-6)  87620-09-5   *Peptide Fragments Neurotensin/*analogs & derivatives Dopamine/metabolism. Eur J Pharmacol 1988;152(1-2):147
neurotensin (8-13)  60482-95-3 L-Leucine, N-(N-(N-(1-(N2-L-arginyl-L-arginyl)-L-prolyl)-L-tyrosyl)-L-isoleucyl)  *Neurotensin *Peptide Fragments. J Neurochem 1988;50(1):131
neuromedin N precursor  0   *Neurotensin *Protein Precursors. Proc Natl Acad Sci USA 1987;84(10):3516
neurotensin, Ser(7)  104969-72-4   Neurotensin/*analogs & derivatives. FEBS Lett 1986;202(2):187
neurotensin, azidobenzoyl-Lys(6)-Trp(11)  95051-06-2 Neurotensin (ox), 6-(N6-(4-azidobenzoyl)-L-lysine)-11-L-tryptophan  *Azides Neurotensin/*analogs & derivatives Iodine Radioisotopes. J Biol Chem 1985;260(1):508
neurotensin, Arg(9)  63770-62-7   Neurotensin/*analogs & derivatives. Neuroscience 1984;12(1):241
neuromedin N  102577-25-3 Neuromedin N  *Neurotensin *Peptide Fragments. Biochem Biophys Res Commun 1984;122(2):542
neurotensin (1-10)  63524-00-5 L-Proline, 1-(N2-(N2-(1-(N2-(N2-(N-(N-(N-(5-oxo-L-prolyl)-L-leucyl)-L-tyrosyl)-L-alpha-glutamyl)-L-asparaginyl)-L-lysyl)-L-prolyl)-L-arginyl)-L-arginyl)  *Neurotensin *Peptide Fragments Pyrrolidonecarboxylic Acid/*analogs & derivatives. Brain Res 1984;301(1):153
neurotensin (1-8)  80887-44-1 Neurotensin (ox), 9-de-L-arginine-10-de-L-proline-11-de-L-tyrosine-12-de-L-isoleucine-13-de-L-leucine  *Neurotensin *Peptide Fragments Pyrrolidonecarboxylic Acid/*analogs & derivatives. Brain Res 1984;301(1):153
neurotensin, Phe(11)  64088-66-0 Neurotensin, 11-D-phenylalanine  Neurotensin/*analogs & derivatives. J Pharmacol Exp Ther 1983;227(3):743
neurotensin, iodo-Tyr(11)  88096-16-6 Neurotensin, 11-(3-(iodo-125I)-L-tyrosine)  Neurotensin/*analogs & derivatives Iodine Isotopes. Scand J Clin Lab Invest 1983;43(6):483
neurotensin, iodo-Tyr(3)  88096-15-5 Neurotensin, 3-(3-(iodo-125I)-L-tyrosine)  Neurotensin/*analogs & derivatives Iodine Isotopes. Scand J Clin Lab Invest 1983;43(6):483
neurotensin-related hexapeptide  85213-84-9 L-Leucine, N-(N-(N-(1-(N2-L-lysyl-L-asparaginyl)-L-prolyl)-L-tyrosyl)-L-isoleucyl)  *Oligopeptides Neurotensin. J Biol Chem 1983;258(4):2475
acetylneurotensin (8-13)  74853-69-3 L-Leucine, N-(N-(N-(1-(N2-(N2-acetyl-L-arginyl)-L-arginyl)-L-prolyl)-L-tyrosyl)-L-isoleucyl)  *Peptide Fragments Neurotensin/*analogs & derivatives. Eur J Biochem 1982;124(1):117
neurotensin-like immunoreactivity  0   *Neuropeptides Neurotensin. Neuroscience 1981;6(7):1329
neurotensin, Gln(4)  61445-54-3   Neurotensin/*analogs & derivatives. Acta Physiol Scand 1980;109(4):369
neurotensin, Trp(11)  75644-95-0   Neurotensin/*analogs & derivatives. Eur J Pharmacol 1980;61(3):309

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