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Nicotinic Acids

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Definition: 2-, 3-, or 4-Pyridinecarboxylic acids. Pyridine derivatives substituted with a carboxy group at the 2-, 3-, or 4-position. The 3-carboxy derivative (NIACIN) is active as a vitamin.  /defic: consider also PELLAGRA; /ther use: coordinate disease with /drug ther, not /diet ther   
Pharmacological Action Vitamin B Complex
Examples Arecoline; Clonixin; Etazolate; Niacin; Niacinamide; Niceritrol; Niflumic Acid; Pipemidic Acid; Piromidic Acid; Xanthinol Niacinate 		Other names Acids, Nicotinic
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid  0   *Imidazoles *Nicotinic Acids Glucokinase/antagonists & inhibitors. J Med Chem. 2012 Feb 9;55(3):1318-33.
2-(5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoyloxy)ethyl nicotinate  0   *Nicotinic Acids Gemfibrozil/*analogs & derivatives. Eur J Pharm Sci. 2011 Jan 14;43(3):99-108.
1,3-bis(4,6-dimethyl-1H-nicotinonitrile-1-yl)1,3-dioxy propane  0   *Nicotinic Acids *Nitriles. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Sep;79(5):1267-75
nicotinyl tryptophanate  0   *Nicotinic Acids *Schiff Bases Tryptophan/*analogs & derivatives. Radiats Biol Radioecol. 2010 Jul-Aug;50(4): 472-4
nicotinyl tyrosinate  0   *Nicotinic Acids *Schiff Bases Tyrosine/*analogs & derivatives. Radiats Biol Radioecol. 2010 Jul-Aug;50(4): 472-4
N'-(2-methyl-3-phenylallylidene)nicotinohydrazide  0   *Hydrazines *Nicotinic Acids. Spectrochim Acta A Mol Biomol Spectrosc 2010 Oct 15;77(3):687-95
6-fluoronicotinic acid 2,3,5,6-tetrafluorophenyl ester  0   *Nicotinic Acids Fluorine Radioisotopes. J Med Chem 2010 Feb 25;53(4):1732-40
N-methylpyridine-2-carboxamide  0   *Nicotinic Acids Ligands. Appl Radiat Isot 2010 Jan;68(1):90-5
2-(2-chlorobenzylamino)-1-(2,3-dihydro-1H-inden-1-yl)-1H-imidazo(4,5-b)pyridine-5-carboxamide  0   *Imidazoles *Nicotinic Acids Acetyl-CoA Carboxylase/antagonists & inhibitors. Bioorg Med Chem Lett 2009 Dec 1;19(23):6507-14
3-carboxy-1-octylcarbamoylmethylpyridinium  0   *Nicotinic Acids. Proc Natl Acad Sci U S A 2009 Jun 30;106(26):10678-83
sodium 6-((5-chloro-2-(((4-chloro-2-fluorophenyl)methyl)oxy)phenyl)methyl)-2-pyridinecarboxylate  0   *Nicotinic Acids Receptors, Prostaglandin E/antagonists & inhibitors. Bioorg Med Chem Lett. 2009 May 1;19(9):2599-603
celangulatin I  0   *Nicotinic Acids *Sesquiterpenes. Nat Prod Res 2009;23(5):470-8
celangulatin H  0   *Nicotinic Acids *Sesquiterpenes. Nat Prod Res 2009;23(5):470-8
celangulatin G  0   *Nicotinic Acids *Sesquiterpenes. Nat Prod Res 2009;23(5):470-8
4-hydroxy-2-methyl-3-pyridinecarboxylic acid  0   *Nicotinic Acids. Dalton Trans 2009 Mar 14;(10):1815-24
1,6-dimethyl-4-hydroxy-3-pyridinecarboxylic acid  0   *Nicotinic Acids. Dalton Trans 2009 Mar 14;(10):1815-24
octyl nicotinate  0   *Nicotinic Acids. Biopharm Drug Dispos 2008 Jul;29(5):308-10
phenyl nicotinate  0   *Nicotinic Acids. Biopharm Drug Dispos 2008 Jul;29(5):308-10
3-amino-5-chloro-6-methoxy-4-methyl-thieno(2,3-b)pyridine-2-carboxylic acid cyclopropylamide  0   *Nicotinic Acids *Thiophenes. Proc Natl Acad Sci U S A 2008 Aug 5;105(31):10978-83
5-(2-fluoroethyl) 2,4-diethyl-3-(ethylsulfanylcarbonyl)-6-phenylpyridine-5-carboxylate  0   *Nicotinic Acids Fluorine Radioisotopes. Nucl Med Biol 2008 Jan;35(1):61-6
2-(2-(3,4-dichlorophenyl)-2,3-dihydro-1H-isoindol-5-ylamino)nicotinic acid  0   *Nicotinic Acids *Isoindoles. Mol Pharmacol 2008 Mar;73(3):639-51
N-phenyl-2-pyridinecarboxamide  0   *Nicotinic Acids. Spectrochim Acta A Mol Biomol Spectrosc 2007 Sep;68(1):184-90
HUM 5007  0   *Cholecalciferol *Ascorbic Acid *Nicotinic Acids *Plant Extracts Dehydroepiandrosterone/*analogs & derivatives. J Nutr Biochem 2007 Sep;18(9):629-34
meso-cinchomeronimide  0   *Imides *Nicotinic Acids. J Am Chem Soc 2006 Jun 14;128(23):7670-8
KR-62436  0   *Nicotinic Acids *Nitriles. Eur J Pharmacol 2005 Jul 25;518(1):63-70
AEC623892  0   *Anthranilic Acids *Nicotinic Acids. Pest Manag Sci 2005 Jul;61(7):705-14
2-amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-piperidin-4-yl nicotinonitrile  0   *Nicotinic Acids *Nitriles. Clin Cancer Res. 2005 Mar 1;11(5):1694-703
nicotinoyl-N-oxysuccinimide  0   *Nicotinic Acids *Succinimides. J Biol Chem 2005 Jan 28;280(4):2536-42
pepluanin A  0   *Diterpenes *Nicotinic Acids. J Med Chem 2004 Feb 12;47(4):988-92
imazapic  0   *Imidazoles *Nicotinic Acids. Pest Manag Sci 2002 Sep;58(9):917-9
4-hydroxy-3-pyridinecarboxylic acid  609-70-1   *Nicotinic Acids. Rapid Commun Mass Spectrom 2003;17(18):2039-46
Fmoc-N-epsilon-(Hynic-Boc)-lysine  0   *Nicotinic Acids Lysine/*analogs & derivatives Ligands. J Med Chem 2003 Apr 24;46(9):1751-7
nicoboxil  13912-80-6   *Nicotinic Acids. Plast Reconstr Surg 2003 Mar;111(3):1207-11
diflufenzopyr  109293-97-2   *Nicotinic Acids *Semicarbazones. Pest Manag Sci 2002 Oct;58(10):1002-14
4-(2-(p-hydroxybenzoyl)vinyl)phenyl nicotinate  0   *Benzylidene Compounds *Nicotinic Acids. Leuk Res 2003 Jan;27(1):57-64
dichlorotetrakis(nicotinic acid)ruthenium(II)  0   *Nicotinic Acids *Organometallic Compounds Ruthenium. J Inorg Biochem 2001 Sep;86(2-3):587-94
azidobenzoylneonicotinoid  0   *Nicotinic Acids. J Neurochem 2001 Sep;78(6):1359-66
azidoneonicotinoid  0   *Nicotinic Acids. J Neurochem 2001 Sep;78(6):1359-66
methyl 2-methoxy-6-methylaminopyridine-3-carboxylate  0   *Nicotinic Acids. Chem Pharm Bull (Tokyo) 2000 Dec;48(12):1847-53
5-bromo-2-methoxy-6-methylaminopyridine-3-carboxylic acid  0   *Nicotinic Acids. Chem Pharm Bull (Tokyo) 2000 Dec;48(12):1847-53
hydroxynicotinic acid phosphate  0   *Nicotinic Acids. Biofizika 2001 Jan-Feb;46(1):34-8
SC 71952  0   *Nicotinic Acids. J Lipid Res 2000 Oct;41(10):1604-14
dichlorotetrakis(3,5-pyridinedicarboxylic acid)ruthenium(II)  0   *Nicotinic Acids *Organometallic Compounds. J Inorg Biochem 1999 Sep 30;76(3-4):153-63
2-nitrooxyethyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)pyridine-5-carboxylate  0   *Nicotinic Acids. Bioorg Med Chem Lett 1999 Sep 6;9(17):2613-4
6-hydrazinopyridine-3-carboxylic acid  0   *Hydrazines *Nicotinic Acids Ligands. Nucl Med Biol 1999 May;26(4):389-96
diethyl 1,4-dihydro-2,6-dimethyl-4-(4'-(4H-4-oxo-1-benzopyran-2-yl)phenyl)-3,5-pyridinedicarboxylate  0   *Chromones *Nicotinic Acids. Pharmazie 1999 Apr;54(4):255-9
OPC 13463  73372-63-1   *Nicotinic Acids Nifedipine/*analogs & derivatives. Drug Metab Dispos 1999 Feb;27(2):303-8
3-methyl-5-phenylethyl 1,4-dihydro-2,6-dimethyl-4-(1-methyl-2-methylsulfonyl-5-imidazolyl)-3,5-pyridinedicarboxylate  0   *Nicotinic Acids. Pharm Acta Helv 1998 Jul;73(2):75-9
2-aminonicotinic acid  5345-47-1   *Nicotinic Acids. Acta Crystallogr C 1997 Oct 15;53( Pt 10):1427-9
N-methyl-5-hydroxynicotinic acid  0   *Nicotinic Acids. Biochemistry 1997 Nov 11;36(45):13856-64
FG 5974  0   *Nicotinic Acids *Piperazines. J Pharm Exp Ther 1997 Aug;282(2):747-59
5-pyridoxic acid  524-07-2   *Nicotinic Acids. Methods Enzymol 1997;280:22-9
2-methyl-3-hydroxypyridine-5-carboxylic acid  0   *Nicotinic Acids. Biochemistry 1997 Jul 1;36(26):8060-70
5-hydroxynicotinic acid  27828-71-3   *Nicotinic Acids. Biochemistry 1997 Jul 1;36(26):8060-70
N,N'-bis(6-(N-3-dimethylaminopropyl)carbamoylpyridin-2-yl)pyridine-2,5-dicarboxamide  0   *Nicotinic Acids *Picolinic Acids. Rocz Akad Med Bialymst 1996;41(2):293-304
PAK 104P  131356-86-0   *Cyclic P-Oxides *Nicotinic Acids. Cancer Res 1990 May 15;50(10):3055-61
chromium nicotinic acid complex  0   *Nicotinic Acids *Organometallic Compounds Chromium. J Dairy Sci 1996 Jul;79(7):1278-83
5-methyl-1-nicotinoyl-2-pyrazoline  0   *Nicotinic Acids. Stroke 1996 Sep;27(9):1624-8
N-glucopyranosylnicotinic acid  0   *Nicotinic Acids Glucose/*analogs & derivatives. Biosci Biotechnol Biochem 1996 Feb;60(2):333-4
5-bromonicotinic acid  20826-04-4   *Nicotinic Acids. J Pharm Sci 1995 Sep;84(9):1120-5
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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