encyclopedia of medical concepts
ψ 
ψ 
ψ 
ψ 

Nitric Oxide

More information in Books or onNLM PubMed
Definition: A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.     
Pharmacological Action Bronchodilator Agents; Endothelium-Dependent Relaxing Factors; Free Radical Scavengers; Neurotransmitter Agents
See Also Endothelium-Dependent Relaxing Factors; Nitric Oxide Donors 		Other names Vasodilator, Endogenous Nitrate; Oxide, Nitric; Nitric Oxide, Endothelium Derived; Nitrate Vasodilator, Endogenous; Monoxide, Nitrogen; Monoxide, Mononitrogen; Endothelium-Derived Nitric Oxide; Nitrogen Monoxide; Nitric Oxide, Endothelium-Derived; Mononitrogen Monoxide; Endogenous Nitrate VasodilatorDrugs* : INOMAX
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
(Z)-2-(9-anthrylmethoxy)-1-phenyldiazene 1-oxide  0   *Anthracenes *Nitric Oxide. Chemistry. 2009 Jul 13;15(28):6802-6
nitrosonium ion  0   *Nitric Oxide. Nitric Oxide 2004 Nov;11(3):256-62
methyl-N-2-dimethylaminoethyl-3-aminoproprionid-nitric oxide  0   *Dimethylamines *Nitric Oxide. Crit Care Med 2005 Mar;33(3):616-22
dipropylenetriamine-NONOate  0   *Alkenes Nitric Oxide. Carcinogenesis 2002 Mar;23(3):469-75
prunioside A  0   *Glycosides *Terpenes Nitric Oxide/antagonists & inhibitors. J Nat Prod 2001 Jul;64(7):942-4
nitric oxide scavenger 100  0   *Nitric Oxide. Transplantation 2000 Jan 27;69(2):227-31
8-cyano-4-(4-methylpiperidino)-7-morpholinopyrido(3',2'-4,5)thieno(3,2-d)-1,2,3-triazine  0   *Thiophenes *Triazines Nitric Oxide/antagonists & inhibitors Dinoprostone/antagonists & inhibitors. J Med Chem 1999 Nov 4;42(22):4720-4
7-(N-4'-acetylphenylpiperazino)-8-cyano-4-chloropyrido(3',2'-4,5)thieno(3,2-d)-1,2,3-triazine  0   *Thiophenes *Triazines Nitric Oxide/antagonists & inhibitors Dinoprostone/antagonists & inhibitors. J Med Chem 1999 Nov 4;42(22):4720-4
1,5-bisacetoxy-8-angeloyloxy-3,4-epoxy-bisabola-7(14),10-dien-2-one  0   *Sesquiterpenes Nitric Oxide/antagonists & inhibitors. J Nat Prod 1999 Oct;62(10):1437-8
2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid  0   Oleanolic Acid/*analogs & derivatives Nitric Oxide/antagonists & inhibitors. Bioorg Med Chem Lett 1998 Oct 6;8(19):2711-4
rhododendrol  0   *Butanols Nitric Oxide/antagonists & inhibitors. Planta Med 1998 Oct;64(7):598-602
PAPA NONOate  0   *Hydrazines *Nitric Oxide.
Pharma Action Nitric Oxide Donors 		J Biol Chem 1998 May 29;273(22):13475-81
2-(dimethylamino)ethylputreanine-nitric oxide adduct  0   *Amino Acids, Diamino *Nitric Oxide Nitric Oxide Donors. J Appl Physiol 1997 Dec;83(6):1968-75
ethylputreanine-nitric oxide adduct  0   *Amino Acids, Diamino *Nitric Oxide Nitric Oxide Donors. J Appl Physiol 1997 Dec;83(6):1968-75
monomalonic acid C(60)  0   *Malonates Nitric Oxide/antagonists & inhibitors. Gen Pharmacol 1997 Sep;29(3):345-51
Roussin's red salt  58204-17-4   *Nitric Oxide *Iron Compounds. Anal Biochem 1997 May 1;247(2):193-202
N(G)-hydroxy-arginine-nitric oxide adduct  0   *Nitric Oxide Arginine/*analogs & derivatives. Proc Natl Acad Sci U S A 1995 May 9;92(10):4671-5
nitrosonium tetrafluoroborate  14635-75-7   *Borates *Nitric Oxide. FEBS Lett 1994 Jul 18;348(3):223-7
hemoglobin A, glycosylated-nitric oxide complex  0   *Hemoglobin A, Glycosylated *Nitric Oxide. J Inorg Biochem 1988;34(1):19
nebivolol  99200-09-6   *Benzopyrans *Ethanolamines Nitric Oxide Platelet Aggregation Inhibitors.
Pharma Action Antihypertensive Agents ; Vasodilator Agents ; Adrenergic beta-1 Receptor Antagonists 		Angiology 1987;38(6):440BYSTOLIC
myoglobin nitroxide  0   *Myoglobin Nitric Oxide. J Biol Chem 1981;256(15):7849
5,6,7,8-tetrahydrobiopterin  17528-72-2   Biopterin/*analogs & derivatives Nitric Oxide Nitric Oxide Synthase. Anal Biochem 89(1):71;1978; Ann Clin Lab Sci 7(2):178;1977; Arch Dis Child 53(8):674;1978; Arch Dis Child 54(5):329;1979; Biochem J 157(1):105;1976; Biochem J 171:267;1978; Biochim Biophys Acta 1980;611(1):241; Cancer Biochem Biophys 2(2):71;1978; Cancer Biochem Biophys 2(2):79;1978; Cancer Treat Rep 62(12):1999;1978; J Biol Chem 253(5):1598;1978; J Neural Transm 45(1):4;1979; J Neurochem 30:899;1978; J Neurochem 32(1):179;1979; J Neurochem 32(5):1575;1979; J Pediatr 1980;96(5):854; Lancet 1(7971):1236;1976; Lancet 1(8109):215;1979; Lancet 1(8115):556;1979; Lancet 1(8119):782;1979KUVAN

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy