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Nitrogen Mustard Compounds

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Definition: A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but now function as antineoplastic agents. These compounds are also powerful mutagens, teratogens, immunosuppressants, and carcinogens.  alkyating antineoplastics; do not confuse with NITROGEN MUSTARD, a specific chemical; DF: NITROGEN MUSTARD CPDS   
Pharmacological Action Antineoplastic Agents, Alkylating
Examples Aniline Mustard; Chlorambucil; Estramustine; Mannomustine; Mechlorethamine; Melphalan; Phosphoramide Mustards; Propylbenzilylcholine Mustard; Quinacrine Mustard; Uracil Mustard 		Other names Mustard Compounds, Nitrogen; Compounds, Nitrogen Mustard
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ZR 2003  0   *Nitrogen Mustard Compounds *Quinazolines Receptor, Epidermal Growth Factor/antagonists & inhibitors. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1135-8.
BO-1051  0   *Nitrogen Mustard Compounds. Biochem Pharmacol. 2011 Mar 1;81(5):594-605
3-hydroxy-17-acetamidoandrostan-7-one-4-N,N-bis(2-chloroethyl)aminophenyl acetate  0   *Nitrogen Mustard Compounds Androsterone/*analogs & derivatives. Mutat Res 2009 Apr 30;675(1-2):51-9
3-hydroxy-17a-azahomoandrostan-7-one-4-N,N-bis(2-chloroethyl)aminophenyl acetate  0   *Azasteroids *Nitrogen Mustard Compounds. Mutat Res 2009 Apr 30;675(1-2):51-9
3-hydroxyandrostan-7,17-dione-4-N,N-bis(2-chloroethyl)aminophenyl butyrate  0   *Nitrogen Mustard Compounds Androsterone/*analogs & derivatives. Mutat Res 2009 Apr 30;675(1-2):51-9
alkamin  0   *Anilides *Nitrogen Mustard Compounds. Chem Res Toxicol 2009 Jan;22(1):146-57
SN 28343  0   *Nitrogen Mustard Compounds Prodrugs. Cancer Gene Ther 2007 Dec;14(12):953-67
PR-104A  0   *Nitrogen Mustard Compounds. Int J Radiat Oncol Biol Phys 2007 Oct 1;69(2):560-71
PR-104  0   *Nitrogen Mustard Compounds. Clin Cancer Res 2007 Jul 1;13(13):3922-32
3-hydroxy-3-aza-A-homoandrosten-4-one-4-bis(2-chloroethyl)aminophenoxyacetate  0   *Azasteroids *Nitrogen Mustard Compounds. Cancer Lett 2006 Nov 18;243(2):202-10
(3-(4-(bis(2-chloroethyl)amino)phenyl)-3-propyl)carbamic acid 2-(6-(17-hydroxy-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-11-yl)hexylamino)ethyl ester  0   *Nitrogen Mustard Compounds *Steroids Carbon Radioisotopes. Mol Cancer Ther 2006 Apr;5(4):977-84
N1-(4-(4-(bis(2-chloroethyl)amino)butoxy)acridin-9-yl)-5-methoxybenzene-1,3-diamine  0   *Aminoacridines *Nitrogen Mustard Compounds. J Med Chem 2006 Jun 15;49(12):3710-8
N1-(4-(2-(bis(2-chloroethyl)amino)ethoxy)acridin-9-yl)-5-methoxybenzene-1,3-diamine  0   *Aminoacridines *Nitrogen Mustard Compounds. J Med Chem 2006 Jun 15;49(12):3710-8
glutaryl C-Mel  0   *Cephalosporins *Nitrogen Mustard Compounds. Bioconjug Chem 2006 Mar-Apr;17(2):410-8
fluorenhymustine  0   *Nitrogen Mustard Compounds. Exp Oncol 2005 Dec;27(4):279-85
(N,N-bis(2-chloroethyl))-2-aminoethyl-3-((acridin-9-yl)amino)propionate  0   *Acridines *Nitrogen Mustard Compounds. Transfusion 2005 Nov;45(11):1739-49
(1,4,7,10-tetra(2-chloroethyl)-1,4,7,10-tetraazacyclododecane)copper(II)  0   *Nitrogen Mustard Compounds *Organometallic Compounds Copper. J Med Chem 2004 Nov 4;47(23):5683-9
naphthalmustine  0   *Isoquinolines *Nitrogen Mustard Compounds. J Exp Clin Cancer Res 2003 Sep;22(3):411-8
(3,5-difluoro-4-(bis(2-chloroethyl)amino)phenyl)carbamoyl-glutamic acid  0   *Nitrogen Mustard Compounds Glutamic Acid/*analogs & derivatives. J Med Chem 2004 May 6;47(10):2651-8
MGB1 compound  0   *Benzimidazoles *Nitrogen Mustard Compounds. Mutat Res 2000 Mar 14;448(1):35-45
MGB2 compound  159277-19-7   *Benzimidazoles *Nitrogen Mustard Compounds. Mutat Res 2000 Mar 14;448(1):35-45
bis(2-chloroethyl)ethylamine  538-07-8   *Nitrogen Mustard Compounds. J Chromatogr A 1999 Jul 23;849(2):529-40
PNU 157977  0   *Distamycins *Nitrogen Mustard Compounds. Anticancer Drug Des 1999 Feb;14(1):71-6
3-hydroxy-13-amino-13,17-seco-5alpha-androstan-17-oic-13,17-lactam 2-N,N-bis(2-chloroethyl)aminobenzoate  157757-66-9   *Azasteroids *Nitrogen Mustard Compounds. Chemotherapy 1999 Jan-Feb;45(1):61-7
2,4-dinitrobenzamide nitorgen mustard  0   *Nitrogen Mustard Compounds. Br J Cancer 1998 Aug;78(4):439-45
3-nor-pentyl-3-(1',1'-dimethylheptyl)-11-(N,N-bis(2-chloroethyl)amino)-delta(8)-tetrahydrocannabinol  0   *Nitrogen Mustard Compounds Tetrahydrocannabinol/*analogs & derivatives. Neuropharmacology 1996;35(12):1793-804
faranoxi  159126-29-1   *Nitrogen Mustard Compounds. J Chemother 1996 Feb;8(1):67-9
imidazole mustard  5034-77-5   *Nitrogen Mustard Compounds.
phenesterin  3546-10-9   *Nitrogen Mustard Compounds.
MEN 10710  0   *Distamycins *Nitrogen Mustard Compounds. Nucleic Acids Res 1996 Jan 15;24(2):311-5
4-(N,N-bis(2-chloroethyl))aminophenyl-N-((1,3-dicarboxy)propyl)carbamate  0   *Nitrogen Mustard Compounds. Proc Natl Acad Sci U S A 1996 Jan 23;93(2):799-803
ZD 2767  0   *Nitrogen Mustard Compounds. J Med Chem 1995 Dec 22;38(26):5051-65
4-((2-chloroethyl) (2-mesyloxyethyl)amino)benzoic acid  122665-70-7   *Nitrogen Mustard Compounds *Benzoic Acids. Cell Biophys 1993 Jan-Jun;22(1-3):1-8
4-((2-chloroethyl)(2-mesyloxyethyl)amino)benzoylglutamic acid  122665-73-0   *Glutamates *Nitrogen Mustard Compounds. Cell Biophys 1993 Jan-Jun;22(1-3):1-8
acridine mustard  146-59-8   *Aminoacridines *Nitrogen Mustard Compounds.
Pharma Action Mutagens ; Antineoplastic Agents, Alkylating
BMS 181095  0   *Nitrogen Mustard Compounds. Anticancer Drugs Res 1994 Oct;9(5):471-6
phthalmustine  156250-83-8 1H-Isoindole-1,3(2H)-dione, 2-(2-(bis(2-chloroethyl)amino)ethyl)  *Nitrogen Mustard Compounds *Phthalimides. Neoplasm 1994;41(1):35-8
SN 24771  0   *Nitrogen Mustard Compounds *Organometallic Compounds Cobalt. Int J Radiat Oncol Biol Phys 1994 May 15;29(2):323-7
SN 25246  0   *Nitrogen Mustard Compounds. Int J Radiat Oncol Biol Phys 1994 May 15;29(2):317-21
7-(4-carboxybutanamido)cephalosporin mustard  142478-50-0   *Cephalosporins *Nitrogen Mustard Compounds. Bioconjug Chem 1993 Sep-Oct;4(5):334-40
4-N,N-bis(2-chloroethyl)aminophenoxyacetic acid  17528-53-9   *Nitrogen Mustard Compounds *Phenoxyacetates. Anticancer Res 1993 Jul-Aug;13(4):1203-8
cypenhymustine  150380-35-1 1,3-Diazaspiro(4.4)nonane-2,4-dione, 3-(2-(bis(2-chloroethyl)amino)ethyl)  *Hydantoins *Nitrogen Mustard Compounds. Cancer Lett 1993 Jun 15;70(1-2):1-6
4-(3'-di(2-chloroethyl)aminopropionyl)biphenyl  142058-12-6   *Biphenyl Compounds *Nitrogen Mustard Compounds Neurotoxins. Neurochem Int 1992 Apr;20(3):289-97
4-(3'-di(2-bromoethyl)aminopropionyl)biphenyl  142058-13-7   *Biphenyl Compounds *Nitrogen Mustard Compounds Neurotoxins. Neurochem Int 1992 Apr;20(3):289-97
alpha, alpha'-bis(di(2-chloroethyl)amino)-4,4'-(2-biacetophenone)  125518-25-4   *Biphenyl Compounds *Nitrogen Mustard Compounds Neurotoxins. Neurochem Int 1992 Apr;20(3):289-97
3-hydroxy-N-methyl-17-aza-D-homoandrostan-17-one-4-N,N-bis(2-chloroethyl)aminophenylacetate  146678-52-6   *Androstanes *Azasteroids *Nitrogen Mustard Compounds. Anticancer Res 1992 Sep-Oct;12(5):1617-20
3-hydroxy-17-aza-D-homoandrostan-4-N,N-bis(2-chloroethyl)aminophenylacetate  146678-51-5   *Androstanes *Azasteroids *Nitrogen Mustard Compounds. Anticancer Res 1992 Sep-Oct;12(5):1617-20
bis(2-chloroethyl)ammonium hexachlorostannate  144088-29-9   *Nitrogen Mustard Compounds *Organometallic Compounds Tin. Acta Crystallogr C 1992 Aug 15;48(Pt 8):1490-1
cephalosporin mustard  139914-00-4   *Cephalosporins *Nitrogen Mustard Compounds. Bioconjug Chem 1992 Mar-Apr;3(2):176-81
N,N'-bis(2-chloroethyl)-N,N'-dimethyl-1,16-hexadecanediamine  74023-14-6   *Decamethonium Compounds *Nitrogen Mustard Compounds. Fiziol Zh SSSR 1991 Jul;77(7):23-8
5-hydroxy-6-(N,N-bis(2-chloroethyl)aminomethyl)naphthalene-1,8-carbolactone  134274-45-6   *Naphthols *Nitrogen Mustard Compounds. Pharmazie 1992 Jan;47(1):67-8
N-(mono-2-chloroethylmonomethyl)aminobenzoyl glutamic acid  0   *Glutamates *Nitrogen Mustard Compounds. Dis Markers 1991 May-Aug;9(3-4):233-8
COP-PAF protocol  0   Prednisolone *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Nitrogen Mustard Compounds Vincristine. Ter Arkh 1991;63(7):61-4
5-(bis(2-chloroethyl)amino)-1-methylbenzimidazolyl-2-acetic acid methyl ester  134426-36-1   *Nitrogen Mustard Compounds. Pharmazie 1991;46(2):113
NSC 620480  89043-18-5   *Azasteroids *Nitrogen Mustard Compounds. Methods Find Exp Clin Pharmacol 1990;12(7):501
tallimustine  115308-98-0 1H-Pyrrole-2-carboxamide, N-(5-(((3-amino-3-iminopropyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-4-(((4-((4-(bis(2-chloroethyl)amino)benzoyl)amino)-1-methyl-1H-pyrrol-2-yl)carbonyl)amino)-1-methyl  *Distamycins *Nitrogen Mustard Compounds.
Pharma Action Antineoplastic Agents ; Antineoplastic Agents, Alkylating 		Cancer Res 1991;51(1):199
WB 4291  70974-81-1   *Nitrogen Mustard Compounds. Br J Cancer 1990;62(5):724
1,3-xylyl-di-(2-chloroethyl)amine  30389-86-7   *Nitrogen Mustard Compounds. Ukr Biokhim Zh 1990;62(3):81
2-chloroethylnitrosocarbamoylalanine 17-dihydrotestosterone ester  89083-93-2   *Nitrogen Mustard Compounds Dihydrotestosterone/*analogs & derivatives. Br J Cancer Res 1990;62(1):42
3-(2-chloroethyl)-4-oxo-3H-imidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxylic acid  113942-32-8   *Nitrogen Mustard Compounds. J Med Chem 1990;33(5):1393
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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