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Nitrosamines

More information in Books or onNLM PubMed
Definition: A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties.  carcinogens   
Examples Butylhydroxybutylnitrosamine; Diethylnitrosamine; Dimethylnitrosamine; N-Nitrosopyrrolidine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-((5-(5-(3,5-dimethylpiperazine-1-sulfonyl)-2-ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-7-yl)oxy)-N-methyl-N-nitroso-1,3-thiazol-5-amine  0   *Nitrosamines *Sulfones. J Pharm Biomed Anal 2011 Mar 25;54(4):735-41
N'-nitrosonornicotine 5'-acetate  0   *Nitrosamines. J Org Chem 2009 Apr 3;74(7):2891-2
3-(4-(methylnitrosoamino)-1-hydroxybutyl)pyridine N-oxide  0   *Cyclic N-Oxides *Nitrosamines. Carcinogenesis 1991 Jun;12(6):1029-34
4-(2-aminoethyl(nitrosamino))-1-pyridin-3-yl-butan-1-one  0   *Nitrosamines. Bioconjug Chem 2007 Nov-Dec;18(6):2045-53
N-acetyl-N-nitrosotryptophan  0   *Nitrosamines Tryptophan/*analogs & derivatives. Org Biomol Chem. 2005 Jun 7;3(11):2085-90
5'-acetoxy-N'-nitrosonornicotine  0   *Nitrosamines Nicotine/*analogs & derivatives. Chem Res Toxicol 2006 Mar;19(3):426-35
2-nitrosoamino-3,8-dimethylimidazo(4,5-f)quinoxaline  0   *Imidazoles *Nitrosamines *Quinoxalines. Chem Res Toxicol. 2006 Feb;19(2):325-33
N-nitroso-3-hydroxymorpholine  0   *Morpholines *Nitrosamines. Chem Res Toxicol. 2003 Jun;16(6):715-20
4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol  0   *Nitrosamines *Pyridines. Clin Exp Immunol 2003 May;132(2):232-8
N-methyl-N-benzylnitrosamine  0   *Nitrosamines. Drug Metabol Drug Interact 2002;19(1):13-27
hydroxy-N-nitrosohexamethyleneimine  0   *Nitrosamines. Carcinogenesis 1980;1(12):1017-25 In vitro formation and properties of beta- and gamma-hydroxy-N-nitrosohexamethyleneimine. (1017-25) Chemical Specialist Complete:
methyl-2-hydroxypropylnitrosamine  0   *Nitrosamines. Int J Pancreatol. 2000 Apr;27(2):105-12
methyl-2-oxopropylnitrosamine  0   *Nitrosamines. Int J Pancreatol. 2000 Apr;27(2):105-12
methylethanalnitrosamine  0   *Aldehydes *Nitrosamines. Chem Res Toxicol 2000 Feb;13(2):72-81
N-ethyl-N-carboxymethyl-nitrosamine  0   *Nitrosamines. Cancer Lett 1999 Oct 18;145(1-2):143-9
N-nitroso-3-nonyl-5-phenyl-3,6-dihydro-2H-1,3,4-thiadiazine-2-imine  0   *Nitrosamines *Thiadiazines. Pharmazie 1998 Dec;53(12):820-4
4-(methylnitrosoamino)-1--(3-pyridyl)-1-butanol  76014-81-8   *Nitrosamines. Cancer Epidemiol Biomarkers Prev 1995 Dec;4(8):877-84
4-((methylnitrosoamino)-1-(3-pyridyl)but-1-yl)beta-omega-glucosiduronic acid  0   *Glucuronates *Nitrosamines. Cancer Epidemiol Biomarkers Prev 1995 Dec;4(8):877-84
N-(4-amino-1-butyl)-N-nitrosobenzamide  171565-02-9   *Benzamides *Nitrosamines. Biochemistry 1995 Nov 21;34(46):15123-33
4-((hydroxymethyl)nitrosamino)-1-(3-pyridyl)-1-butanone  0   *Nitrosamines. Chem Res Toxicol 1995 Jul-Aug;8(5):772-9
N-nitroso-N-((6-methoxyquinolin-2-yl)methyl)-N'-isobutyrylalaninamide  0   *Nitrosamines Chymotrypsin/antagonists & inhibitors. Bioconjug Chem 1994 Sep-Oct;5(5):454-8
N-nitroso-N-((7-methoxycoumarin-4-yl)methyl)-N'-isobutyrylalaninamide  0   *Nitrosamines Chymotrypsin/antagonists & inhibitors. Bioconjug Chem 1994 Sep-Oct;5(5):454-8
3-(N-carbethoxy-N-nitrosamino)propionaldehyde  0   *Aldehydes *Nitrosamines. Chem Res Toxicol 1993 Jan-Feb;7(1):62-7
tert-butyloxycarbonyl-mononitrosamidocaffeidine  145439-00-5   *Nitrosamines Caffeine/*analogs & derivatives. Mutat Res 1993 Aug;292(1):41-9
dinitrosocaffeidine  145438-97-7   *Nitrosamines Caffeine/*analogs & derivatives. Mutat Res 1993 Aug;292(1):41-9
mononitrosocaffeidine  145438-96-6   *Nitrosamines Caffeine/*analogs & derivatives. Mutat Res 1993 Aug;292(1):41-9
4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone  127686-49-1   *Nitrosamines *Pyridines. Cancer Res 1993 Jun 15;53(12):2780-5
N-nitrosooxprenolol  96497-86-8   *Nitrosamines Oxprenolol/*analogs & derivatives. Pharmacol Toxicol 1992 Aug;71(2):154-8
(1-acetoxypropyl)propylnitrosamine  53198-41-7   *Nitrosamines. Chem Res Toxicol 1988 Sep-Oct;1(5):269-73
N-nitrosomethyl(2-methylbutyl)amine  130787-81-4   *Nitrosamines. Carcinogenesis 1990;11(9):1583
nitrosating enzyme  EC 1.-   *Oxidoreductases Nitrosamines/metabolism. Biochem Biophys Res Commun 1990;171(2):655
N-nitroso(acetoxybenzyl)methylamine  53198-46-2   *Nitrosamines. Chem Biol Interact 1989;72(1-2):175
N-nitrosodihydrodibenzazepine  7458-08-4   *Dibenzazepines *Nitrosamines. Arch Geschwulstforsch 1989;59(4):257
N-nitrosodibenzazepine  38652-29-8   *Dibenzazepines *Nitrosamines. Arch Geschwulstforsch 1989;59(4):257
diazo-N-nitrosoetilefrin  122341-55-3   *Nitrosamines Etilefrine/*analogs & derivatives. Chem Pharm Bull (Tokyo) 1989;37(6):1600
4-(methylnitrosamino)-4-(3-pyridyl)butyric acid  123743-84-0   *Nitrosamines. Carcinogenesis 1989;10(9):1725
1-hydroxy-N-nitrosopiperidine phosphate ester  123016-73-9   *Nitrosamines *Phosphoric Acid Esters. Biochem Biophys Res Commun 1989;162(3):1140
1-(N-ethyl-N-nitrosamino)ethyl phosphate  105528-04-9   *Nitrosamines *Phosphoric Acid Esters. Toxicology 1089;57(1):59
1-(N-methyl-N-nitrosoamino)ethyl phosphate  105514-32-7   *Nitrosamines *Phosphoric Acid Esters. Toxicology 1989;57(1):59
2-ethylhexyl 4-(N-methyl-N-nitrosamino) benzoate  122021-01-6   *Nitrosamines. J Dermatol Surg Oncol 1989;15(5):486
4-hydroxy-N-nitroso-N-methyl-N-cyclohexylamine  124779-46-0   *Nitrosamines. Arzneimittelforschung 1988;38(9):1355
N-butyl-N-(3-formylpropyl)nitrosamine  70625-89-7 Butanal, 4-(butylnitrosoamino)  *Nitrosamines. Carcinogenesis 1988;9(11):2109
diazalo  80-11-5   *Nitrosamines *Tosyl Compounds. Neoplasma 1988;35(3):257
N-nitrosomethyl-(2-hydroxyethyl)amine 4-toluenesulfonate ester  66398-63-8   *Nitrosamines. Cancer Res 1988;48(6):1533
N-nitrosomethyl-(3-hydroxypropyl)amine  70415-59-7   *Nitrosamines. Cancer Res 1988;48(6):1533
N-nitrosomethyl-(2-hydroxyethyl)amine  26921-68-6   *Nitrosamines. Cancer Res 1988;48(6):1533
2-methyl-N-nitrosothiazolidine-4-carboxylic acid  103659-08-1   *Nitrosamines. Food Chem Toxicol 1988;26(1):15
N-nitrosodithiazine  114282-83-6   *Heterocyclic Compounds *Nitrosamines. Food Chem Toxicol 1988;26(1):3
N-methyl-N-(1-acetoxy-2-oxopropyl)nitrosamine  112725-15-2   *Nitrosamines. Cancer Lett 1987;36(3):325
2-(N-nitroso-N-methylamino)propiophenone  110505-04-9   *Nitrosamines. Cancer Lett 1987;35(2):199
4-(methylnitrosoamino)-4-(3-pyridyl)-1-butanol  59578-66-4   *Nitrosamines.
Pharma Action Carcinogens 		Carcinogenesis 1987;8(3):465
N-methyl(methoxymethyl)nitrosamine  39885-14-8   *Nitrosamines. Mol Cell Biol 1986;6(7):2716
methylisoamylnitrosamine  35606-38-3   *Nitrosamines. Sci Sin (B) 1985:28(11):1188
N-nitrosoiminodiacetic acid  25081-31-6   *Nitrosamines. J Cancer Res Clin Oncol 1986;111(2):149
4-(carbethoxynitrosamino)-1-(3-pyridyl)-1-butanone  68743-68-0   *Nitrosamines. Carcinogenesis 1986;7(4):611
4-(carbethoxynitrosamino)-4-(3-pyridyl)butanal  107759-11-5   *Nitrosamines. Carcinogenesis 1986;7(4):611
N-nitrosoproline ethyl ester  16339-06-3   *Nitrosamines. Chung Kuo I Hsueh Ko Hsueh Yuan Hsueh Pao 1985;7(2):130
3-methylnitrosaminopropionaldehyde  85502-23-4   *Nitrosamines. IARC Monogr Eval Carcinog Risk Chem Hum 1985;37:263
4-(methylnitrosamino)-4-(3-pyridyl)butanal  64091-90-3   *Nitrosamines. IARC Monogr Eval Carcinog Risk Chem Hum 1985;37:205
N-nitroso-prolyl-4-hydroxyproline  88476-96-4   *Dipeptides *Nitrosamines. Food Addit Contam 1984;1(4):307
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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