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Norepinephrine

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Definition: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.     
Pharmacological Action Adrenergic alpha-Agonists; Sympathomimetics; Vasoconstrictor Agents
See Also Receptors, Adrenergic
Examples Normetanephrine 		Other names Noradrenaline; Levonorepinephrine; Levarterenol; tartrate renaudin, Noradr+¬naline; renaudin, Noradr+¬naline tartrate; Hydrochloride, Norepinephrine; Bitartrate, Norepinephrine; Bitartrate, Noradrenaline; Bitartrate, Levophed; Renaudin Brand of Norepinephrine Bitartrate; Norepinephrine, (+,-)-Isomer; Norepinephrine, (+)-Isomer; Norepinephrine l-Tartrate, (+)-Isomer; Norepinephrine l-Tartrate (1:2); Norepinephrine l-Tartrate (1:1), Monohydrate, (+); Norepinephrine l-Tartrate (1:1), Monohydrate; Norepinephrine l-Tartrate (1:1), (+,-)-Isomer; Norepinephrine l-Tartrate (1:1); Norepinephrine d-Tartrate (1:1); Norepinephrine Hydrochloride, (+,-)-IsomerDrugs* : LEVOPHED; NOREPINEPHRINE BITARTRATE; RAVOCAINE AND NOVOCAIN W/ LEVOPHED
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Dopamine beta hydroxylase deficiency  0   *Autonomic Nervous System Diseases Dopamine beta-Hydroxylase/deficiency Norepinephrine/deficiency.
syncarpamide  0   Norepinephrine/*analogs & derivatives Polyunsaturated Alkamides. J Nat Prod 2004 Jan;67(1);88-90
4-coumaroylnoradrenaline  0   Norepinephrine/*analogs & derivatives. J Biol Chem 2003 Oct 31;278(44):43373-83
ethyl 2-(2-chloro-4-(2-((2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl)amino)ethyl)phenoxy)acetate  0   Norepinephrine/*analogs & derivatives Receptors, Adrenergic, beta-3/agonists. J Med Chem 2003 Jan 2;46(1):105-12
2-(2-chloro-4-(2-((2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl)amino)ethyl)phenoxy)acetic acid  0   Norepinephrine/*analogs & derivatives Receptors, Adrenergic, beta-3/agonists. J Med Chem 2003 Jan 2;46(1):105-12
5-cysteinylnorepinephrine  0   Norepinephrine/*analogs & derivatives. Chem Res Toxicol 2000 Aug;13(8):749-60
6-nitronorepinephrine  0   Norepinephrine/*analogs & derivatives. J Biol Chem 1996 Jun 7;271(23):13561-5
N-acetylarterenone  14522-07-7 Acetamide, N-(2-(3,4-dihydroxyphenyl)-2-oxoethyl)  Norepinephrine/*analogs & derivatives. Arch Insect Biochem Physiol 1992;20(3):181-91
N-acetylnorepinephrine  30959-88-7 Acetamide, N-(2-(3,4-dihydroxyphenyl)-2-hydroxyethyl)-, (R)  Norepinephrine/*analogs & derivatives. FEBS Lett 1989;252(1-2):135
N-(4-azido-3-iodophenethylamidoisobutyl)norepinephrine  117685-73-1   *Azides Norepinephrine/*analogs & derivatives. J Biol Chem 1988;263(28):14410
6-chloronorepinephrine  101996-38-7   Norepinephrine/*analogs & derivatives. Arzneimittelforschung 1986;36(3):457
2-chloronorepinephrine  101969-79-3 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-3-chloro-, (R)  Norepinephrine/*analogs & derivatives. Arzneimittelforschung 1986;36(3):457
bromoacetylaminomenthylnorepinephrine  99081-70-6   Norepinephrine/*analogs & derivatives. J Biol Chem 1985;260(29):15820
aminomenthylnorepinephrine  99081-68-2   Norepinephrine/*analogs & derivatives. J Biol Chem 1985;260(29):15820
norepinephrine glucuronide  0   Norepinephrine/*analogs & derivatives. Life Sci 1985;37(16):1469
lidocaine, norepinephrine, vasopressin drug combination  0   *Lidocaine *Norepinephrine *Vasopressins. Schweiz Monatsschr Zahnmed 1984;94(4):307
6-fluoronorepinephrine  86820-21-5 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-5-fluoro  Norepinephrine/*analogs & derivatives. J Pharmacol Exp Ther 1980;212(3):382
3-fluoronorepinephrine  71144-40-6 1,2-benzenediol, 4-(2-amino-1-hydroxyethyl)-3-fluoro-, (+-)  Norepinephrine/*analogs & derivatives. J Pharmacol Exp Ther 1980;212(3):382
noradrenaline sulfate  81138-41-2 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, hydrogen sulfate (ester), (R)  Norepinephrine/*analogs & derivatives. Arch Int Physiol Biochim 85:945;1978
dipivaloylnorepinephrine  65114-84-3 Propanoic acid, 2,2-dimethyl-, 4-(2-amino-1-hydroxyethyl)-1,2-phenylene ester, (R)  Norepinephrine/*analogs & derivatives. J Pharm Exp Ther 203(2):442;1977
nisoxetine  57226-61-6   Fluoxetine/*analogs & derivatives Norepinephrine/antagonists & inhibitors. Arch Int Pharmacodyn Ther 229(1):42;1977; Biochem Pharmacol 25:1979;1976; Br J Clin Pharmacol 3(2):215;1976; Br J Clin Pharmacol 4(1):91;1977; Eur J Pharmacol 1979;60(4):379; Eur J Pharmacol 44(3):219;1977; J Mol Cell Cardiol 10(11):1031;1978; J Pharm Sci 65(3):457;1976; J Pharmacol Exp Ther 1982;222(1):61; Life Sci 17(5):755;1975; Life Sci 20(2):275;1977; Neuropharmacology 1979;18(10):767; Neuropharmacology 1979;18(10):813; Psychopharmacol Commun 1(5):455;1975; Psychopharmacol Commun 2(3):181;1976; Psychopharmacology 1979;64(3):291; Res Commun Chem Pathol Pharmacol 15(2):221;1976
protokylol  136-70-9   *Dioxolanes Norepinephrine/*analogs & derivatives. Jpn J Anesthesiol 24(1):78;1975VENTAIRE
ethylnorepinephrine  536-24-3 alpha-(1-aminopropyl)-3,4-dihydroxybenzyl alcohol  Norepinephrine/*analogs & derivatives.
norparanephrine  32655-70-2   Norepinephrine/*analogs & derivatives. Biochem Pharmacol 20(12):3353;1971
noradrenalone  499-61-6   Norepinephrine/*analogs & derivatives. Arch Int Pharmacodyn Ther 192(2):279;1973
noradrenaline theophylline  13460-98-5 7-(2-(2-hydroxy-2-(3,4-dihydroxyphenyl)ethylamino)ethyl)theophylline  Norepinephrine/*analogs & derivatives Theophylline/*analogs & derivatives Hypotension/drug therapy. Arzneim Forsch 22(4):693;1972
6-hydroxynoradrenaline  2623-77-0 5-(2-amino-1-hydroxyethyl)-1,2,4-benzenetriol  Norepinephrine/*analogs & derivatives. Eur J Pharmacol 20(2):149;1972
4-hydroxyphenylisopropylarterenol  2549-15-7 4-(1-hydroxy-2-((2-(4-hydroxyphenyl)-1-methylethyl)amino)ethyl)-1,2-benzenediol  Norepinephrine/*analogs & derivatives.
N-cyclopentylbutanephrine  13725-15-0   Norepinephrine/*analogs & derivatives. Arch Int Pharmacodyn Ther 193(2):287;1971; Pharmacology 14:158;1976

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