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Novobiocin

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Definition: An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189)     
Pharmacological Action Anti-Bacterial Agents; Enzyme Inhibitors; Nucleic Acid Synthesis Inhibitors 		Other names Streptonivicin; Crystallinic Acid; Sodium, Novobiocin; Monosodium Salt Novobiocin; Calcium, Novobiocin; Novobiocin, Monosodium Salt; Novobiocin Sodium; Novobiocin CalciumDrugs* : ALBAMYCIN
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
novobiocin 401  0   Novobiocin/*analogs & derivatives DNA Gyrase/antagonists & inhibitors. Chem Biol 2011 Mar 25;18(3):304-13
KU135  0   Novobiocin/*analogs & derivatives. Mol Pharmacol. 2009 Dec;76(6):1314-22
7-tosylcyclonovobiocic acid  0   Novobiocin/*analogs & derivatives. Biochem Biophys Res Commun 2009 Feb 6;379(2):514-8
4-tosylcyclonovobiocic acid  0   Novobiocin/*analogs & derivatives. Biochem Biophys Res Commun 2009 Feb 6;379(2):514-8
novclobiocin 114  0   Novobiocin/*analogs & derivatives. Chem Biol. 2004 Nov;11(11):1561-72
novclobiocin 102  0   Novobiocin/*analogs & derivatives. Chem Biol 2003 Mar;10(3):279-88
novclobiocin 101  0   Novobiocin/*analogs & derivatives. Chem Biol 2003 Mar;10(3):279-88
TPU-0031-B  0   Novobiocin/*analogs & derivatives Streptomyces. J Antibiot (Tokyo) 2001 May;54(5):441-7
TPU-0031-A  0   Novobiocin/*analogs & derivatives Streptomyces. J Antibiot (Tokyo) 2001 May;54(5):441-7
dihydronovobiocin  29826-16-2   Novobiocin/*analogs & derivatives Enzyme Inhibitors. Biochemistry 1996 Apr 16;35(15):5083
2''-O-carbamylnovobiocin  138686-58-5   Novobiocin/*analogs & derivatives. J Antibiotic (Tokyo) 1991;44(10):1096
albamycin T  8021-84-9   Novobiocin Tetracycline. Przegl Dermatol 1988;75(3):204
novenamine  31026-09-2 2H-1-Benzopyran-2-one, 3-amino-7-((3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-alpha-L-lyxo-hexopyranosyl)oxy)-4-hydroxy-8-methyl  Novobiocin/*analogs & derivatives. J Antibiot (Tokyo) 1986;39(2):272
Albacillin  8025-50-1 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenylacetyl)amino)- (2S-(2alpha,5alpha,6beta))-, mixt. with N-(7-((3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-beta-L-lyxo-hexopyranosyl)oxy)-4-hydroxy-8-methyl-2-o  *Glycerides *Novobiocin *Penicillin G Procaine. J Dairy Sci 1984;67(8):1841
antibiotic 2562  76773-72-3   Novobiocin/analogs & derivatives. Antibiotiki 1980;25(7):483
isonovobiocin  10543-94-9 Benzamide, N-(7-((2-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-alpha-L-lyxo-hexopyranosyl)oxy)-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl)-4-hydroxy-3-(3-methyl-2-butenyl)  *Novobiocin. Antibiotiki 23(8):686;1978
descarbamylnovobiocin  10544-02-2 Benzamide, N-(7-((6-deoxy-5-C-methyl-4-O-methyl-beta-L-lyxo-hexopyranosyl)oxy)-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl)-4-hydroxy-3-(3-methyl-2-butenyl)  Novobiocin/*analogs & derivatives. Antibiotiki 23(8):686;1978
clorobiocin  39868-96-7   Novobiocin/*analogs & derivatives. J Antibiotics 26(3):121;1973; MGG 1979;177(1):103

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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