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Oleanolic Acid

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Definition: A pentacyclic triterpene that occurs widely in many PLANTS as the free acid or the aglycone for many SAPONINS. It is biosynthesized from lupane. It can rearrange to the isomer, ursolic acid, or be oxidized to taraxasterol and amyrin.      Other names Oleanol; Triterpenes, Oleanane; Oleanane Triterpenes; Hederins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-O-beta-D-glucopyranosyl-28-O-(beta-D-glucopyranosyl(1-2))-beta-D-glucopyranosyl-21beta,22alpha-dihydroxyl-olean-12-ene  0   *Saponins Oleanolic Acid/*analogs & derivatives. J Asian Nat Prod Res. 2012;14(3):216-23
3-O-beta-D-glucopyranosyl(1-6)-(angeloyl(1-2))-beta-D-glucopyranosyl-28-O-alpha-L-rhamnopyranosyl(1-2)-(beta-D-glucopyranosyl(1-6))-beta-D-glucopyranosyl-21beta,22alpha-dihydroxyl-olean-12-ene  0   *Saponins Oleanolic Acid/*analogs & derivatives. J Asian Nat Prod Res. 2012;14(3):216-23
vaccaroside B  0   *Saponins Oleanolic Acid/*analogs & derivatives. Fitoterapia. 2011 Oct;82(7):1106-9
olean-13(18)-ene-3,12,19-trione  0   Oleanolic Acid/*analogs & derivatives. Fitoterapia. 2011 Oct;82(7):960-3
3beta-hydroxy-11alpha,12alpha-epoxyoleanan-28,13beta-olide  0   Oleanolic Acid/*analogs & derivatives. Nat Prod Commun. 2011 Nov;6(11):1569-72
mussaendoside T  0   *Saponins Oleanolic Acid/*analogs & derivatives. J Asian Nat Prod Res. 2011 Oct;13(11):1008-13
3beta,4beta,23-trihydroxy-24-nor-olean-12-en-28-oic acid  0   Oleanolic Acid/*analogs & derivatives. J Nat Prod. 2011 Oct 28;74(10):2116-21
3beta,23-dihydroxy-30-nor-olean-12,20-dien-28-oic acid  0   Oleanolic Acid/*analogs & derivatives. J Nat Prod. 2011 Oct 28;74(10):2116-21
23-deoxypaeonenoide A  0   Oleanolic Acid/*analogs & derivatives. J Nat Prod. 2011 Oct 28;74(10):2116-21
(2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) trifluoroethylamide  0   Oleanolic Acid/*analogs & derivatives. Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5339-47.
dipsacus saponin K  0   *Saponins Oleanolic Acid/*analogs & derivatives. Asian Nat Prod Res. 2011 Sep;13(9):851-60
dipsacus saponin J  0   *Saponins Oleanolic Acid/*analogs & derivatives. Asian Nat Prod Res. 2011 Sep;13(9):851-60
fatsicarpain A  0   Oleanolic Acid/*analogs & derivatives. J Nat Prod. 2011 Aug 26;74(8):1744-50
3-oxoolean-12-en-27-oic acid  0   Oleanolic Acid/*analogs & derivatives. Anticancer Res 2011 Jun;31(6):2179-85
ZCVI4-2  0   Oleanolic Acid/*analogs & derivatives. Chem Pharm Bull (Tokyo). 2011;59(6):734-41
celosin B  0   *Saponins Oleanolic Acid/*analogs & derivatives. Nat Prod Res. 2011 Apr;25(8):772-80
celosin A  0   *Saponins Oleanolic Acid/*analogs & derivatives. Nat Prod Res. 2011 Apr;25(8):772-80
1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl)-4-ethynylimidazole  0   *Imidazoles Oleanolic Acid/*analogs & derivatives. Bioorg Med Chem Lett 2011 Apr 15;21(8):2188-91
1alpha,3beta-dihydroxy-olean-9(11),12-dien  0   *Oleanolic Acid. Chem Pharm Bull (Tokyo). 2011;59(4):496-8
1alpha,3beta-dihydroxy-11a -methoxy-olean-12-ene  0   *Oleanolic Acid. Chem Pharm Bull (Tokyo). 2011;59(4):496-8
2,3-seco-olean-12-ene-2,3,28-trioic acid  0   Oleanolic Acid/*analogs & derivatives. Chem Pharm Bull (Tokyo). 2011;59(3):397-401
3-O-(alpha-L-arabinopyranosyl(1-2)-alpha-L-arabinopyranosyl(1-6))-2-acetamido-2-deoxy-beta-D-glucopyranosyl acacic acid lactone  0   *Saponins Oleanolic Acid/*analogs & derivatives. J Nat Prod. 2011 Mar 25;74(3):477-82
3-O-(alpha-L-arabinopyranosyl(1-6))-2-acetamido-2-deoxy-beta-D-glucopyranosyl oleanolic acid  0   *Saponins Oleanolic Acid/*analogs & derivatives. J Nat Prod. 2011 Mar 25;74(3):477-82
chichipegenin  0   Oleanolic Acid/*analogs & derivatives. Z Naturforsch C. 2011 Jan-Feb;66(1-2):24-30
1beta-hydroxy-3-oxo-olean-11-en-28,13-lactone  0   Oleanolic Acid/*analogs & derivatives. Planta Med. 2010 Nov;76(16):1904-7
1beta,11alpha,21beta-trihydroxy-3-oxo-olean-12-en-28-oic acid  0   Oleanolic Acid/*analogs & derivatives. Planta Med. 2010 Nov;76(16):1904-7
1beta,11alpha-dihydroxy-3-oxo-olean-12-en-28-oic acid  0   Oleanolic Acid/*analogs & derivatives. Planta Med. 2010 Nov;76(16):1904-7
glaucaside C  0   Oleanolic Acid/*analogs & derivatives Saponins. Magn Reson Chem. 2011 Feb;49(2):83-9
glaucaside B  0   *Saponins Oleanolic Acid/*analogs & derivatives. Magn Reson Chem. 2011 Feb;49(2):83-9
glaucaside A  0   *Saponins Oleanolic Acid/*analogs & derivatives. Magn Reson Chem. 2011 Feb;49(2):83-9
julibroside J  0   *Oleanolic Acid. Fitoterapia. 2010 Oct;81(7):859-63
5-(4-dimethylamino-phenyl)-penta-2,4-dienoic acid  0   Oleanolic Acid/*analogs & derivatives. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Jan;78(1):463-8
3-hydroxyolean-12-en-27-oic acid  0   Oleanolic Acid/*analogs & derivatives. J Asian Nat Prod Res. 2011 Feb;13(2):188-91
3-oxo-28-(phthaloyl-4')erythrane  0   Oleanolic Acid/*analogs & derivatives Protein Tyrosine Phosphatase, Non-Receptor Type 1/antagonists & inhibitors. J Nat Prod. 2010 Nov 29;73(11):1743-50
12-oleanene-3beta,21beta-diol  0   *Oleanolic Acid. Pharm Biol. 2010 Mar;48(3):264-8
polygonoide D  0   *Saponins Oleanolic Acid/*analogs & derivatives. J Asian Nat Prod Res. 2010 Sep;12(9):801-8
polygonoide C  0   *Saponins Oleanolic Acid/*analogs & derivatives. J Asian Nat Prod Res. 2010 Sep;12(9):801-8
polygonoide E  0   *Saponins Oleanolic Acid/*analogs & derivatives. J Asian Nat Prod Res. 2010 Sep;12(9):801-8
terminaliaside A  0   *Saponins Oleanolic Acid/*analogs & derivatives. Phytochemistry. 2010 Jan;71(1):95-9
3-O-beta-D-glucopyranosyl olean-11,13(18)-diene-23,28-dioic acid 28-O-beta-D-glucopyranoside  0   *Saponins Oleanolic Acid/*analogs & derivatives. J Asian Nat Prod Res. 2010 Jun;12(6):458-63
3-O-beta-D-glucopyranosyl olean-9(11),12-diene-23,28-dioic acid 28-O-beta-D-glucopyranoside  0   *Saponins Oleanolic Acid/*analogs & derivatives. J Asian Nat Prod Res. 2010 Jun;12(6):458-63
3,3'-(hexane-1,6-diylbis(1H-1,2,3-triazole-1,4-diylmethanediyloxy))bisolean-12-en-28-oic acid  0   *Triazoles Oleanolic Acid/*analogs & derivatives Glycogen Phosphorylase/antagonists & inhibitors. Chem Biodivers 2010 Mar;7(3):690-7
iminobis(ethane-2,1-diylimino(3b)-28-oxoolean-12-ene-28,3-diyl) diacetate  0   Oleanolic Acid/*analogs & derivatives Glycogen Phosphorylase/antagonists & inhibitors. Chem Biodivers 2010 Mar;7(3):690-7
lysimachiagenoside F  0   *Saponins Oleanolic Acid/*analogs & derivatives. J Asian Nat Prod Res. 2010 Mar;12(3):204-8
lysimachiagenoside E  0   *Saponins Oleanolic Acid/*analogs & derivatives. J Asian Nat Prod Res. 2010 Mar;12(3):204-8
3-O-(beta-D-glucopyranosyl-(1-2)-beta-D-glucopyranosyl-(1-3)-beta-D-glucopyranosyl)-oleanolic acid  0   *Saponins Oleanolic Acid/*analogs & derivatives. Nat Prod Commun. 2010 Feb;5(2):191-5
xanifolia O54  0   *Saponins Oleanolic Acid/*analogs & derivatives. J Nat Med. 2010 Jan;64(1):80-4
sorbifoliaside  0   *Saponins Oleanolic Acid/*analogs & derivatives. J Nat Med. 2010 Jan;64(1):80-4
27-hydroxyoleanolic acid 3-O-alpha-L-arabinopyranosyl-(1 -3)-alpha-L-rhamnopyranosyl-(1-2)-alpha-L -arabinopyranoside  0   *Saponins Oleanolic Acid/*analogs & derivatives. J Nat Med. 2010 Jan;64(1):50-4
27-hydroxyoleanolic acid 3-O-beta-D-glucopyranosyl- (1-4)-alpha-L-arabinopyranoside  0   *Saponins Oleanolic Acid/*analogs & derivatives. J Nat Med. 2010 Jan;64(1):50-4
3-O-beta-D-glucopyranosyl-3-beta-hydroxyolean-12-en-28-oic acid 28-O-(beta-D-glucopyranosyl-(1-2)-beta-D-galactopyranosyl)ester  0   *Saponins Oleanolic Acid/*analogs & derivatives. J Nat Prod. 2010 Feb 26;73(2):247-51
3-O-beta-D-glucopyranosyl-3-beta-hydroxyolean-12-en-28-oic acid 28-O-(beta-D-apiofuranosyl-(1-2)-beta-D-glucopyranosyl)ester  0   *Saponins Oleanolic Acid/*analogs & derivatives. J Nat Prod. 2010 Feb 26;73(2):247-51
3-O-beta-D-glucopyranosyl-3-beta-hydroxyolean-12-en-28-oic acid 28-O-(alpha-L-rhamnopyranosyl-(1-2)-beta-D-glucopyranosyl)ester  0   *Saponins Oleanolic Acid/*analogs & derivatives. J Nat Prod. 2010 Feb 26;73(2):247-51
lysimachigenoside D  0   Oleanolic Acid/*analogs & derivatives. J Asian Nat Prod Res. 2009 Jun;11(6):529-33
lysimachigenoside C  0   *Saponins Oleanolic Acid/*analogs & derivatives. J Asian Nat Prod Res. 2009 Jun;11(6):529-33
dh404 compound  0   Oleanolic Acid/*analogs & derivatives. PLoS One 2009;4(12):e8391
ardipusilloside V  0   *Saponins Oleanolic Acid/*analogs & derivatives. Chem Biodivers. 2009 Sep;6(9):1443-52
3beta,6beta-dihydroxyolean-12-en-28-oic acid  0   Oleanolic Acid/*analogs & derivatives. Nat Prod Commun. 2009 Oct;4(10):1323-6
polygalasaponin XXXIII  0   *Saponins Oleanolic Acid/*analogs & derivatives. Acta Pharmacol Sin. 2009 Sep;30(9):1211-9
coriarioside B  0   *Saponins Oleanolic Acid/*analogs & derivatives. J Nat Prod. 2009 Oct;72(10):1725-30
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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