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Oligonucleotides

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Definition: Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)  2-12 nucleotides   
Examples Aptamers, Nucleotide; Morpholinos; Oligodeoxyribonucleotides; Oligonucleotides, Antisense; Oligoribonucleotides; Peptide Nucleic Acids; Phosphorothioate Oligonucleotides; Pyrimidine Dimers
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
cenersen  872847-66-0   *Oligonucleotides. Cancer. 2012 Jan 15;118(2):418-27
LY 2275796  0   *Oligonucleotides. Clin Cancer Res. 2011 Oct 15;17(20):6582-91.
ODN JG244  0   *Oligonucleotides. Mol Ther. 2010 Jan;18(1):188-97.
CYT003-QbG10  0   *Oligonucleotides. Mol Interv 2011 Apr;11(2):103-6
ASO 144367  0   *Oligonucleotides Oligonucleotides, Antisense. J Am Coll Cardiol. 2011 Apr 12;57(15):1611-21
EZN 3042  0   *Oligonucleotides. Nucleosides Nucleotides Nucleic Acids 2010 Feb;29(2):97-112
S110 compound  0   *Oligonucleotides Azacitidine/*analogs & derivatives. Mol Cancer Ther 2010 May;9(5):1443-50
SurKex  0   *Oligonucleotides. Int J Cancer 2010 May 15;126(10):2426-36
5'-oleic-TAGGGTTAGACAA-3'  0   *Oligonucleotides Telomerase/antagonists & inhibitors. Breast Cancer Res Treat 20-09 Nov;118(1):21-32
AVI-4658  0   *Oligonucleotides. Curr Opin Neurol. 2009 Oct;22(5):532-8
T30923  0   *Oligonucleotides. Thromb Haemost. 2009 Sep;102(3):529-37
GS 101  0   *Oligonucleotides. J Pharmacol Exp Ther 2009 May;329(2):496-504
CpG-ODN DSP30  0   *Oligonucleotides. Exp Hematol 2000 May;28(5):558-68
EZN 2968  0   *Oligonucleotides. Mol Cancer Ther 2008 Nov;7(11):3598-608
ISIS 183891  0   *Oligonucleotides. Prostate 2008 Sep 1;68(12):1283-95
RX 0047  0   *Oligonucleotides. J Cell Biochem 2008 Jun 1;104(3):985-94
LY 2181308  0   *Oligonucleotides. Int J Radiat Oncol Biol Phys 2008 May 1;71(1):247-55
ENA-1 oligonucleotide  0   *Oligonucleotides. Nucleic Acids Symp Ser (Oxf) 2007;(51):111-2
amino-LNA  0   *Oligonucleotides. Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1645-7
PRO051  0   *Oligonucleotides. N Engl J Med. 2007 Dec 27;357(26):2677-86
ISIS 301012  0   *Oligonucleotides. Circulation 2006 Oct 17;114(16):1729-35
antagomir-122  0   *Oligonucleotides. Nature 2005 Dec 1;438(7068):685-9
ISIS 110159  0   *Oligonucleotides. Mol Cancer Ther 2006 Nov;5(11):2727-36
RB 007  0   *Oligonucleotides. Circulation 2006 Dec 5;114(23):2490-7
5'-O-phosphoryl-1'-deoxy-2'-isoadenylyl-3'-5'-cytidine  0   *Oligonucleotides. Acta Crystallogr C 2005 Aug;61(Pt 8):o518-20
ATL 227446  0   *Oligonucleotides Oligonucleotides, Antisense. J Endocrinol 2006 Apr;189(1):147-54
NOX-B11  0   *Oligonucleotides. Gut 2006 Jun;55(6):754-5
r(GGCGBrUGCGCU)2  0   *Oligonucleotides. Acta Crystallogr D Biol Crystallogr. 2006 Mar;62(Pt 3):331-8
NOX-B11-2  0   *Oligonucleotides. Endocrinology 2006 Mar;147(3):1517-26
HYB-2055  0   *Oligonucleotides. Curr Opin Mol Ther 2005 Aug;7(4):376-83
GRN163L peptide  0   *Oligonucleotides Telomerase. Hepatology 2005 Nov;42(5):1127-36
ODN ID35  0   *Oligonucleotides. Cell Microbiol. 2005 Mar;7(3):403-14
oligonucleotide 5005  0   *Oligonucleotides. Oligonucleotides 2004;14(3):199-209
edifoligide  0   *Oligonucleotides. Vasc Endovascular Surg 2005 Jan-Feb;39(1):15-23
d(G3T4G4)2  0   *Oligonucleotides. Nucleic Acids Res. 2005;33(11) (dup#3):3691-7
AEG 35156  0   *Oligonucleotides. Br J Cancer 2005 Feb 14;92(3);532-8
psoAG10 compound  0   *Oligonucleotides Trioxsalen/*analogs & derivatives. J Biol Chem 1995 Sep 22;270(38):22595-601
ORI 9020  0   *Oligonucleotides. Antimicrob Agents Chemother 2004 Jun;48(6):2318-20
11mer daunomycin-conjugated GT  0   *Daunorubicin *Oligonucleotides. Nucleic Acids Res 2004;32(8) (dup#3):2396-410
RBI 011  0   *Oligonucleotides. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1733-6
GRN163  0   *Oligonucleotides. Cancer Res. 2003 Oct 1;63(19):6187-94
locked nucleic acid  0   *Oligonucleotides. Trends Biotechnol 2003 Feb;21(2):74-81
C274 oligonucleotide  0   *Oligonucleotides. J Leukoc Biol. 2003 Jun;73(6):781-92
GTI2501  236391-67-6   *Oligonucleotides. Curr Opin Investig Drugs 2001 Oct;2(10):1467-70
technetium MAG3-cMORF  0   *Oligonucleotides *Organotechnetium Compounds. J Nucl Med 2002 Mar;43(3):384-91
alpha-homo-DNA  0   *Oligonucleotides. Chemistry 2001 Dec 3;7(23):5183-94
INX-3280  0   *Oligonucleotides Genes, myc. Antisense Nucleic Acid Drug Dev 2001 Jun;11(3):155-63
AS-3m oligonucleotide  0   *Oligonucleotides. Blood 2001 Sep 15;98(6):1904-13
LR-3280  0   *Oligonucleotides. Antisense Nucleic Acid Drug Dev 2001 Apr;11(2):99-106
NX1838  0   *Oligonucleotides. Pharm Res 2000 Dec;17(12):1503-10
GEM231  0   *Oligonucleotides. J Chromatogr B Biomed Sci Appl 2001 Jan 5;750(1):129-35
oligonucleotide 4625  0   *Oligonucleotides. J Natl Cancer Inst 2001 Mar 21;93(6):463-71
9-(2-deoxy-2-fluoro-arabinofuranosyl)-adenine  0   *Oligonucleotides. Nucleosides Nucleotides Nucleic Acids 2000 Oct-Dec;19(10-12)
FSU oligonucleotide  0   *Oligonucleotides Telomerase/antagonists & inhibitors. Anal Biochem 2000 Jun 15;282(1):80-8
pentadecathymidylic acid  0   *Oligonucleotides. Nucleic Acids Res 2000 May 1;28(9):E40
CHEVP, oligonucleotide  0   *Oligonucleotides *Porphyrins. FEBS Lett 1999 Dec 3;462(3):467-71
HYB 165  0   *Oligonucleotides Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors. Clin Cancer Res 1999 Apr;5(4):875-81
LJP 685  0   *Oligonucleotides. Lupus 1998;7 Suppl 2:S166-69
2'-deoxythymidylyl-(3'-5')-N(4)-palmitoyl-2',3'-dideoxycytidine  0   *Oligonucleotides *Dideoxynucleotides. Antivir Chem Chemother 1998 Mar;9(2):117-26
N(4)-hexadecyl-2'-deoxycytidylyl--(3'-5')-2',3'-dideoxycytidine  0   *Oligonucleotides. Antivi Chem Chemother 1998 Mar;9(2):117-26
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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