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Oxidoreductases

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Definition: The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)  X refs OXIDASES; REDUCTASES & DEHYDROGENASES are GEN only: see Tree D8 under OXIDOREDUCTASES for all indentions & choose the most specific   
Examples Alcohol Oxidoreductases; Arsenate Reductases; Ascorbate Oxidase; Ceruloplasmin; Electron Transport Complex IV; Hydrogenase; Laccase; Luciferases; 5,10-Methylenetetrahydrofolate Reductase (FADH2); NADH, NADPH Oxidoreductases; Nitrogenase; Nitroreductases; Oxidoreductases Acting on Aldehyde or Oxo Group Donors; Oxidoreductases Acting on CH-CH Group Donors; Oxidoreductases Acting on CH-NH Group Donors; Oxidoreductases Acting on CH-NH2 Group Donors; Oxidoreductases Acting on Sulfur Group Donors; Oxidoreductases, O-Demethylating; Oxygenases; Methionine Sulfoxide Reductases; Peroxidases; Plastoquinol-Plastocyanin Reductase; Ribonucleotide Reductases; Succinate Cytochrome c Oxidoreductase; Superoxide Dismutase; Urate Oxidase 		Other names Reductase; Oxidase; Dehydrogenase; Reductases; Oxidases; Dehydrogenases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
DHRS7c protein, human  EC 1.-   *Oxidoreductases. Eur J Heart Fail. 2012 Jan;14(1):5-13.
ARC2 protein, human  EC 1.-   *Membrane Proteins *Oxidoreductases Mitochondrial Proteins. Eukaryot Cell. 2011 Oct;10(10):1270-82.
TYW1 protein, S cerevisiae  EC 1.-   *Oxidoreductases *Saccharomyces cerevisiae Proteins Iron-Sulfur Proteins. J Biol Chem. 2011 Nov 4;286(44):38488-97.
KefF protein, E coli  EC 1.-   *Oxidoreductases *Escherichia coli Proteins. J Bacteriol 2011 Sep;193(18):4925-32
Foxred2 protein, rat  EC 1.-   *Oxidoreductases. Cell Mol Life Sci 2011 Jun;68(12):2115-27
MCO3 protein, Drosophila  EC 1.-   *Oxidoreductases *Drosophila Proteins. J Exp Biol 2011 Mar 15;214(Pt 6):971-8
Schlank protein, drosophila  EC 1.3.1.-   *Oxidoreductases *Drosophila Proteins. Results Probl Cell Differ. 2010;52():175-81
mitochondrial amidoxime reducing component 1, human  EC 1.-   *Oxidoreductases *Mitochondrial Proteins. J Biol Chem 2010 Nov 26;285(48):37847-59
mitochondrial amidoxime reducing component 2, human  EC 1.-   *Oxidoreductases *Mitochondrial Proteins. J Biol Chem 2010 Nov 26;285(48):37847-59
ATR3 protein, Arabidopsis  EC 1.-   *Oxidoreductases *Arabidopsis Proteins. New Phytol 2010 Jul;187(1):67-82
Tah18 protein, S cerevisiae  EC 1.-   *Oxidoreductases *Saccharomyces cerevisiae Proteins. Nat Chem Biol 2010 Oct;6(10):758-65
GliT protein, Aspergillus fumigatus  EC 1.-   *Oxidoreductases. PLoS Pathog 2010;6(6):e1000952
2-oxoacid dehydrogenase complex, Haloferax volcanii  EC 1.-   *Oxidoreductases *Archaeal Proteins. Microbiology. 2010 Feb;156(Pt 2):521-9
Grx3 protein, S cerevisiae  EC 1.-   *Oxidoreductases *Saccharomyces cerevisiae Proteins. Biochemistry 2009 Oct 13;49(40):9569-81
Bli-3 protein, C elegans  EC 1.-   *Oxidoreductases *Caenorhabditis elegans Proteins. Eukaryot Cell 2009 Aug;8(8):1218-27
LPR1 protein, Arabidopsis  EC 1.-   *Oxidoreductases *Arabidopsis Proteins. Proc Natl Acad Sci U S A 2009 Aug 18;106(33):14174-9
DsbL protein, E coli  EC 1.-   *Oxidoreductases *Escherichia coli Proteins. J Bacteriol 2009 Jun;191(12):3901-8
brassinin oxidase, Leptosphaeriae maculans  EC 1.-   *Oxidoreductases. FEBS J 2008 Jul;275(14):3691-705
HYL-2 ceramide synthase, C elegans  EC 1.3.1.-   *Oxidoreductases *Caenorhabditis elegans Proteins. Science. 2009 Apr 17;324(5925):343-4
DHRS4 protein, human  EC 1.1.1.184   *Oxidoreductases Protein Isoforms. Biosci Rep. 2009 Feb;29(1):47-56
Bile acid synthesis defect, congenital, 2  0   *Cholestasis *Metabolism, Inborn Errors Oxidoreductases/deficiency.
amidoxime reducing component, human  EC 1.-   *Oxidoreductases Metalloproteins. J Med Chem 2008 Dec 25;51(24):8173-7
artemisinic aldehyde delta11(13) reductase, Artemisia annua  EC 1.-   *Oxidoreductases *Plant Proteins. J Biol Chem 2008 Aug 1;283(31):21501-8
Aifm2 protein, mouse  EC 1.-   *Oxidoreductases *Apoptosis Regulatory Proteins. Apoptosis 2008 May;13(5):729-32
corrin reductase, Brucella melitensis  EC 1.-   *Oxidoreductases. J Biol Chem 2008 Apr 18;283(16):10813-21
Des2 protein, rat  EC 1.3.1.-   *Oxidoreductases. Biochimie 2007 Dec;89(12):1553-61
Des1 protein, rat  EC 1.3.1.-   *Oxidoreductases. Biochimie 2007 Dec;89(12):1553-61
tRNA dihydrouridine synthase-2, human  EC 1.3.-   *Oxidoreductases. Nucleic Acids Res 2008 Feb;36(3):998-1008
Fre7 protein, S cerevisiae  EC 1.-   *Oxidoreductases *Saccharomyces cerevisiae Proteins. J Biol Chem Sep 28;292(39):28619-26
Fre6 protein, S cerevisiae  EC 1.-   *Oxidoreductases *Saccharomyces cerevisiae Proteins. J Biol Chem Sep 28;292(39):28619-26
IspD protein, E coli  EC 1.1.1.267   *Multienzyme Complexes *Oxidoreductases *Aldose-Ketose Isomerases *Escherichia coli Proteins. J Org Chem. 2006 Nov 10;71(23):8824-34
salutaridine reductase, Papaver  EC 1.1.1.248   *Oxidoreductases. Chem Res Toxicol 1998 Oct;11(10):1176-83
MsrB protein, mouse  EC 1.8.4.6   *Oxidoreductases. Free Radic Res 2007 Feb;41(2):162-71
phycocyanobilin-ferredoxin oxidoreductase, Nostoc  EC 1.3.7.5   *Oxidoreductases. Biochemistry 2007 Feb 13;46(6):1484-94
HY2 protein, Arabidopsis  EC 1.3.7.4   *Oxidoreductases. Plant Cell 2001 Feb;13(2):425-36
DMSP demethylase, Roseobacter  EC 1.-   *Oxidoreductases. Science 2006 Oct 27;314(5799):649-52
LAC1 protein, S cerevisiae  EC 1.3.-   *Oxidoreductases *Saccharomyces cerevisiae Proteins Protein Subunits. Eukaryot Cell 2004 Aug;3(4):880-92
arsenate reductase 2, Arabidopsis  EC 1.-   *Multienzyme Complexes *Oxidoreductases *cdc25 Phosphatases *Arabidopsis Proteins. Proc Natl Acad Sci U S A 2006 Apr 4;103(14):5413-8
NinaG protein, Drosophila  EC 1.-   *Oxidoreductases *Drosophila Proteins. J Biol Chem 2006 Apr 7;281(14):9205-9
YieF protein, E coli  EC 1.-   *Oxidoreductases *Escherichia coli Proteins. Appl Environ Microbiol 2004 Feb;70(2):873-82
SKS6 protein, Arabidopsis  0   *Oxidoreductases. Planta 2005 Nov;222(4):652-66
MET16 protein, S cerevisiae  EC 1.-   *Oxidoreductases *Saccharomyces cerevisiae Proteins. Nucleic Acids Res 2006;34(3) (dup#3):976-85
triphenylmethane reductase, Citrobacter  EC 1.-   *Oxidoreductases. Appl Environ Microbiol 2005 Dec;71(12):7955-60
Hsdl2 protein, mouse  EC 1. -   *Oxidoreductases. Mol Biol (Mosk). 2005 Sep-Oct;39(5):799-805
YhcB protein, E coli  EC 1.9.3.-   *Oxidoreductases *Escherichia coli Proteins Protein Subunits Electron Transport Chain Complex Proteins. J Biol Chem 2005 Oct 14;280(41):34409-19
divinyl reductase; Arabidopsis  EC 1.3.-   *Oxidoreductases *Arabidopsis Proteins. Plant Cell. 2005 Jan;17(1):233-40
STEAP4 protein, human  EC 1.16.1.-   *Membrane Proteins *Oxidoreductases. Oncogene 2005 Jul 21;24(31):4934-45
short fiber generating factor, Gloeophyllum trabeum  EC 1.-   *Fungal Proteins *Oxidoreductases. Biotechnol Lett 2004 Dec;26(23):1799-802
PCB2 protein, Arabidopsis  EC 1.-   *Oxidoreductases *Arabidopsis Proteins. Plant Cell Physiol 2005 Mar;46(3):467-73
gamma-N-methylaminobutyrate demethylating oxidase  EC 1.-   *Oxidoreductases. Eur J Biochem 2004 Dec;271(23-24):4677-84
dihydromethyl-trisporate dehydrogenase  EC 1.-   *Oxidoreductases. Gene 2005 Mar 28;348:33-44
cueO protein, E coli  EC 1.-   *Oxidoreductases *Escherichia coli Proteins.
Cybrd1 protein, mouse  EC 1.6.99.-   *Cytochrome b Group *Oxidoreductases.
YedY protein, E coli  EC 1.-   *Oxidoreductases *Escherichia coli Proteins Membrane Proteins. J Biol Chem 2004 Nov 26;279(48):50391-400
fluorinase  EC 1.-   *Bacterial Proteins *Oxidoreductases. Nature 2002 Mar 21;416(6878):279
quiescin sulfhydryl oxidase, rat  EC 1.8.3.-   *Oxidoreductases. J Endocrinol 2004 Nov;183(2):353-63
hydroxymethylbutenyl diphosphate reductase, Lycopersicon esculentum  EC 1.-   *Oxidoreductases *Plant Proteins. Plant J 2004 Oct;40(2);188-99
TDR1 protein, Leishmania major  EC 1.16.-   *Oxidoreductases. Biochem J 2004 Jul 15;381(Pt 2):405-12
phycocyanobilin-ferredoxin oxidoreductase, Anabaena  EC 1.3.7.5   *Oxidoreductases. J Am Chem Soc 2004 Jul 21;126(28):8682-93
IRL protein, Citrus x paradisi  0   *Carrier Proteins *Plant Proteins Oxidoreductases.
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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