encyclopedia of medical concepts
ψ 
ψ 

Pancreatic Elastase

More information in Books or onNLM PubMed
Definition: A protease of broad specificity, obtained from dried pancreas. Molecular weight is approximately 25,000. The enzyme breaks down elastin, the specific protein of elastic fibers, and digests other proteins such as fibrin, hemoglobin, and albumin. EC 3.4.21.36.  LEUKOCYTE ELASTASE is also available   
Examples Leukocyte Elastase 		Other names Pancreatopeptidase; Elastase; Elastase, Pancreatic; Elastase I, Pancreatic; Pancreatic Elastase I; Elastase I
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
lobechine  0   *Butyric Acids *Pyrroles Pancreatic Elastase/antagonists & inhibitors. Arch Pharm Res 2011 May;34(5):715-22
lyngbyastatin 10  0   *Depsipeptides Pancreatic Elastase/antagonists & inhibitors. Mar Drugs 2009;7(4):528-38
lyngbyastatin 9  0   *Depsipeptides Pancreatic Elastase/antagonists & inhibitors. Mar Drugs 2009;7(4):528-38
lyngbyastatin 8  0   *Depsipeptides Pancreatic Elastase/antagonists & inhibitors. Mar Drugs 2009;7(4):528-38
microviridin B  0   *Depsipeptides Pancreatic Elastase/antagonists & inhibitors. Angew Chem Int Ed Engl 2008;47(40):7756-9
elastase A, zebrafish  EC 3.4.21.36   *Pancreatic Elastase Zebrafish Proteins. Exp Cell Res 2006 May 15;312(9):1526-39
SSR 69071  0   *Cyclic S-Oxides *Thiazoles Pancreatic Elastase/antagonists & inhibitors. J Pharmacol Exp Ther 2003 May;305(2):451-9
N-phenethylphosphonyl-leucyl-tryptophan  0   *Dipeptides *Phosphonic Acids Pancreatic Elastase/antagonists & inhibitors. Photochem Photobiol 2001 Aug;74(2):283-90
N-phenetylphosphonyl-leucyl-tryptophane  0   *Dipeptides Pancreatic Elastase/antagonists & inhibitors. J Invest Dermatol 2001 Sep;117(3):671-7
CEI protein, Trichuris suis  0   *Proteins Chymotrypsin/antagonists & inhibitors Pancreatic Elastase/antagonists & inhibitors. Exp Parasitol 2000 May;95(1):36-44
ahyB protein, Aeromonas hydrophila  EC 3.4.21.-   *Bacterial Proteins *Pancreatic Elastase. Infect Immun 2000 Jun;68(6):3233-41
ASPI-2 protein, Ascaris suum  0   *Insect Proteins Pancreatic Elastase Serine Proteinase Inhibitors. Mol Biochem Parasitol 1999 Jul 30;102(1):79-89
trifluoroacetyl-lysyl-alaninanilide  0   *Anilides *Dipeptides Pancreatic Elastase/antagonists & inhibitors. Jpn J Pharmacol 1998 Jul;77(3):193-203
tert-butoxycarbonyl-tyrosyl-leucyl-valyl-chloromethane  0   *Oligopeptides Pancreatic Elastase/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1997 Nov;45(11):1845-50
FK 706  0   *Benzoates *Pyrrolidines Pancreatic Elastase/antagonists & inhibitors Leukocyte Elastase/antagonists & inhibitors. Eur J Pharmacol 1997 Oct 15;337(1):63-71
DMP 777  0   *Azetidines *Piperazines Pancreatic Elastase/antagonists & inhibitors. Pharm Res 1996 Dec;13(12):1815-20
trifluoroacetylphenylalanylalanine 4-trifluoromethylanilide  0   *Dipeptides Pancreatic Elastase/antagonists & inhibitors. Biochemistry 1995 Mar 14;34(10):3193-203
trifluoroacetylvalylalanine 4-trifluoromethylanilide  0   *Dipeptides Pancreatic Elastase/antagonists & inhibitors. Biochemistry 1995 Mar 14;34(10):3193-203
FR 901451  0   *Peptides, Cyclic Pancreatic Elastase/antagonists & inhibitors. J Antibiot (Tokyo) 1994 Dec;47(12):1359-64
Myxococcus xanthus alkaline protease 1  EC 3.4.21.-   *Pancreatic Elastase. Eur J Biochem 1994 Aug 1;223(3):775-82
MDL 101146  149859-17-6   *Morpholines *Oligopeptides Pancreatic Elastase/antagonists & inhibitors. J Pharmacol Exp Ther 1994 Jul;270(1):185-91
2-(4-fluorophenyl)-5-((methoxycarbonyl)amino)pyrimidin-4-one-3-ethanoylvaline-trifluoromethylketone  154753-62-5   *Pyrimidinones Pancreatic Elastase/antagonists & inhibitors. J Med Chem 1994 Apr 29;37(9):1259-61
L 680833  127063-08-5   *Lactams *Phenylacetates Pancreatic Elastase/antagonists & inhibitors. Proc Natl Acad Sci U S A 1993 Sep 15;90(18):8727-31
TEI 5624  138006-80-1 Pentanoic acid, 4-(((4-chlorophenyl)sulfonyl)amino)-5-((5-methyl-2-((1-methylethyl)amino)-4-oxo-4H-3,1-benzoxazin-7-yl)amino)-5-oxo-, (S)  *Sulfonamides *Benzoxazines Pancreatic Elastase/antagonists & inhibitors. J Pharmacol Exp Ther 1993 May;265(2):516-23
TEI 6344  149575-57-5 Hexanamide, 6-amino-2-(((4-chlorophenyl)sulfonyl)amino)-N-(5-methyl-2-((1-methylethyl)amino)-4-oxo-4H-3,1-benzoxazin-7-yl)-, monohydrochloride, (S)  *Sulfonamides *Benzoxazines Pancreatic Elastase/antagonists & inhibitors. J Pharmacol Exp Ther 1993 May;265(2):516-23
PVI-3(1) protein, Phaseolus vulgaris  0   *Plant Proteins Pancreatic Elastase/antagonists & inhibitors. Z Lebensm Unters Forsch 1993 Apr;196(4):343-50
L 708286  119720-81-9 L-Prolinamide, N-acetyl-L-alanyl-N-(3,3-difluoro-1-(1-methylethyl)-2,4-dioxo-4-((2-phenylethyl)amino)butyl)-, (S)  *Oligopeptides Pancreatic Elastase/antagonists & inhibitors. Biochemistry 1993 Mar 2;32(8):2031-5
4-nitrophenyl N-(succinyl-alanyl-alanyl-prolylmethyl)-N-isopropylcarbamate  144597-19-3   *Carbamates *Oligopeptides Pancreatic Elastase/antagonists & inhibitors. Am Rev Respir Dis 1992 Aug;146(2):457-61
tetrapeptide carbamate  0   *Carbamates *Oligopeptides Pancreatic Elastase/antagonists & inhibitors. Histochemistry 1992;97(1):69-76
7-((N-tosylphenylalanyl)amino)-4-chloro-3-methoxyisocoumarin  99033-29-1   *Coumarins Phenylalanine/*analogs & derivatives Pancreatic Elastase/antagonists & inhibitors. J Med Chem 1992 Mar 20;35(6):1121-9
N-((4-((((4-chlorophenyl)sulfonyl)amino)carbonyl)phenyl)oxomethyl)-valyl-N-(2,3-dihydro-1H-inden-2-yl)glycine N-(3-(1,1,1-trifluoro-4-methyl-2-oxopentyl))amide  129585-37-1   *Indenes *Oligopeptides Pancreatic Elastase/antagonists & inhibitors. J Med Chem 1992 Feb 21;35(4):641-62
SR 26831  139995-67-8 Thieno(3,2-c)pyridinium, 5-((2-chlorophenyl)methyl)-2-(2,2-dimethyl-1-oxopropoxy)-4,5,6,7-tetrahydro-5-hydroxy  *Pyridines Pancreatic Elastase/antagonists & inhibitors. J Pharmacol Exp Ther 1992 Feb;260(2):809-16
SC 37698  138362-01-3 SC 37698  *Chlorobenzoates Neutrophils Pancreatic Elastase/antagonists & inhibitors. Am J Physiol 1991;261(4 Pt 2):H1255
ICI 200355  105080-32-8 L-Prolinamide, N-(4-((((4-bromophenyl)sulfonyl)amino)carbonyl)benzoyl)-L-valyl-N-(3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl)  *Oligopeptides Pancreatic Elastase/antagonists & inhibitors.
Pharma Action Serine Proteinase Inhibitors 		Eur J Pharmacol 1991;193(2):153
MDL 27399  131374-22-6 L-Phenylalanine, N-(1-(N-(N-(4-methoxy-1,4-dioxobutyl)-L-alanyl)-L-alanyl)-L-prolyl)-, methyl ester  *Oligopeptides Pancreatic Elastase/antagonists & inhibitors. Int J Immunopharmacol 1990;12(7):787
MDL 27324  123285-50-7 L-Prolinamide, N-((5-(dimethylamino)-1-naphthalenyl)sulfonyl)-L-alanyl-L-alanyl-N-(3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl)-, (S)  *Oligopeptides Pancreatic Elastase/antagonists & inhibitors. Int J Immunopharmacol 1990;12(7):777
N-(2-chloromethylphenyl)-3,3-difluoroazetidin-2-one  131230-67-6   Azetidines Pancreatic Elastase/antagonists & inhibitors. Eur J Cell Biol 1990;52(2):213
L 658758  116507-04-1 L-Proline, 1-((3-((acetyloxy)methyl)-7-methoxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-2-yl)carbonyl)-, S,S-dioxide, (6R-cis)  *Cephalosporins Pancreatic Elastase/antagonists & inhibitors.
Pharma Action Serine Proteinase Inhibitors 		Am J Physiol 1990;259(2 Pt 2):H390
trifluoroacetyl-leucyl-alanyl-4-trifluoromethylanilide  119777-90-1   *Dipeptides Pancreatic Elastase/antagonists & inhibitors. J Mol Recognit 1990;3(1)
N-(trifluoroacetyl)valyl-O'-(2,3-epoxypropyl)tyrosyl-valine methyl ester  127132-43-8   *Oligopeptides Pancreatic Elastase/antagonists & inhibitors. J Med Chem 1990;33(6):1620
N-(tert-butoxycarbonyl)alanyl-alanyl-O'-(2,3-epoxypropyl)tyrosine ethyl ester  127132-36-9   *Oligopeptides Pancreatic Elastase/antagonists & inhibitors. J Med Chem 1990;33(6):1620
anhydroelastase  0   *Pancreatic Elastase. J Mol Recognit 1988;1(2):93
methoxysuccinyl-alanyl-alanyl-prolyl-alanine chloromethyl ketone  111682-13-4   *Amino Acid Chloromethyl Ketones Pancreatic Elastase/antagonists & inhibitors. Proc Natl Acad Sci USA 1989;86(1):7
acetylalanyl-prolyl-valyl-trifluoromethyl ketone  116380-62-2   *Oligopeptides Pancreatic Elastase/antagonists & inhibitors. J Mol Biol 1988;201(2):423
(1-(5-methyl-4-oxo-4H-3,1-benzoxazin-2-yl)-2-methylpropyl)carbamic acid 1,1-dimethylethyl ester  108562-42-1   *Carbamates *Benzoxazines Pancreatic Elastase/antagonists & inhibitors. J Mol Biol 1987;198(3):417
lodelaben  111149-90-7   *Chlorobenzoates Neutrophils Pancreatic Elastase/antagonists & inhibitors. Biochem Biophys Res Commun 1987;147(2):666
3-acetoxymethyl-7-chloro-3-cephem-4-carboxylate-1,1-dioxide tert-butylester  95672-01-8   *Lactams Pancreatic Elastase/antagonists & inhibitors. Nature 1987;327(6117):79
3-benzyl-N-(methanesulfonyloxy)succinimide  106847-87-4   *Succinimides Chymotrypsin/antagonists & inhibitors Pancreatic Elastase/antagonists & inhibitors. Biochem Biophys Res Commun 1986;141(2):741
chloroacetyl-N-hydroxyleucyl-alanyl-glycinamide  95602-96-3   *Oligopeptides Pancreatic Elastase/antagonists & inhibitors. J Clin Microbiol 1986;23(1):53
methyl-O-succinyl-alanyl-alanyl-prolyl-borovaline-pinacol  94242-92-9   *Boronic Acids *Oligopeptides Pancreatic Elastase Pancreatic Elastase/antagonists & inhibitors. Am Rec Respir Dis 1986;133(4):635
undecenoyl-aspartyl-dialanyl-proline ethylamide  90068-11-4   *Oligopeptides Pancreatic Elastase/antagonists & inhibitors. Hepatogastroenterology 1985;32(4):206
protease inhibitor protein, Tylosema esculenturm  0   *Plant Proteins Pancreatic Elastase/antagonists & inhibitors. Proc Soc Exp Biol Med 1985;180(2):329
N(alpha)-(1-adamantanesulfonyl)-N(epsilon)-(4-carboxybenzoyl)lysyl-alanyl-valinal  97143-05-0   *Oligopeptides Adamantane/*analogs & derivatives Pancreatic Elastase/antagonists & inhibitors. FEBS Lett 1985;183(2):201
glutaryl-alanyl-alanyl-alanyl-ethylamide  83808-35-9   *Oligopeptides Pancreatic Elastase/antagonists & inhibitors. Cas Lek Cesk 1985;124(2):41
pseudolysin, Pseudomonas aeruginosa  EC 3.4.24.26   *Bacterial Proteins *Metalloendopeptidases Pancreatic Elastase. Can J Microbiol 1984;30(9):1118
alkaline elastase  EC 3.4.21.-   *Pancreatic Elastase Bacillus. Biochem Int 1984;8(2):283
4-hydroxy-6-((1-butyl)heptyl)-2H-pyran-2-one  90632-46-5 2H-Pyran-2-one, 6-(1-butylheptyl)-4-hydroxy  *Pyrones Pancreatic Elastase/antagonists & inhibitors. Experienta 1984;40(4):361
4-methoxy-6-((1-butyl)heptyl)-2H-pyran-2-one  90632-47-6 2H-Pyran-2-one, 6-(1-butylheptyl)-4-methoxy  *Pyrones Pancreatic Elastase/antagonists & inhibitors. Experientia 1984;40(4):361
4-hydroxy-6-undecyl-2H-pyran-2-one  81017-03-0 2H-Pyran-2-one, 4-hydroxy-6-undecyl  *Pyrones Pancreatic Elastase/antagonists & inhibitors. Experienta 1984;40(4):361
ovomucoid inhibitors  0   *Trypsin Inhibitor, Kazal Pancreatic Pancreatic Elastase/antagonists & inhibitors. Biochemistry 1983;22(19):4420
more...

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy