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Papaverine

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Definition: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.     
Pharmacological Action Phosphodiesterase Inhibitors; Vasodilator Agents
Examples Tetrahydropapaveroline 		Other names Hydrochloride, Papaverine; Pavatym; Pavabid; Papaverine Hydrochloride; Cerespan
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
papaverinol N-oxide  0   *Cyclic N-Oxides Papaverine/*analogs & derivatives. Phytochemistry 2000 Mar;53(6):675-8
papaverine salicylate  0   Papaverine/*analogs & derivatives. Agents Actions 1994 Aug;42(1-2):29-33
SDZ ISQ 844  143526-87-8   Papaverine/*analogs & derivatives. Arerugi 1994 Apr;43(4):551-6
atropine, dipyridamole, ifenprodil tartrate, papaverine, piribedil, yohimbine drug combination  0   *Atropine *Dipyridamole *Papaverine *Piperidines *Piribedil *Yohimbine Drug Combinations. J Urol 1991;145(2):287
3'-hydroxypapaverine  18694-10-5   Papaverine/*analogs & derivatives. In Vitro Cell Dev Biol 1990;26(5):515
4'-hydroxypapaverine  18813-60-0   Papaverine/*analogs & derivatives. In Vitro Cell Devl Biol 1990;26(5):515
6-hydroxypapaverine  18813-63-3   Papaverine/*analogs & derivatives. In Vitro Cell Dev Biol 1990;26(5):515
monothreane  0   *Papaverine *Quinine Drug Combinations. Vestn Otorinolaringol 1989;(5):20
A 69024  58939-37-0 7-Isoquinolinol, 1-((2-bromo-4,5-dimethoxyphenyl)methyl)-1,2,3,4-tetrahydro-6-methoxy-2-methyl  Papaverine/*analogs & derivatives Tetrahydroisoquinolines. Eur J Pharmacol 1989;166(3):481
nicospan  99390-77-9   *Nicotinic Acids Drug Combinations Papaverine/*analogs & derivatives. Farmakol Toksikol 1988;51(1):38
papaverine, phentolamine drug combination  0   *Papaverine *Phentolamine Drug Combinations. Urologe (A) 1988;27(1):2
6,7-dimethoxy-4-(4'-amino-3'-iodobenzyl)isoquinoline  104672-05-1   Papaverine/*analogs & derivatives. Mol Pharmacol 1986;30(4):379
perphyllon  8066-99-7   *Atropine Derivatives *Papaverine *Phenobarbital *Theophylline Drug Combinations. Wien Med Wochenschr 1986;136(9):213
spasmo-eunalgit  138230-24-7   *Aminopyrine *Barbiturates *Papaverine *Plant Extracts Drug Combinations. Cesk Patol 1984;20(4):215
papaverine lauryl sulfate  37933-68-9   *Papaverine *Sodium Dodecyl Sulfate Drug Combinations. Pharm Acta Helv 1984;59(11):310
oxadilene  0   *Oxadiazoles *Papaverine Drug Combinations. Phlebologie 1984;37(3):369
papaverinol  482-76-8   Papaverine/*analogs & derivatives. Boll Chim Farm 1983;122(7);322
papaveraldine  522-57-6   Papaverine/*analogs & derivatives. Boll Chim Farm 1983;122(7):322
6,7-dimethoxy-4-(4-chlorobenzyl)isoquinoline  32871-99-1   Papaverine/*analogs & derivatives. Ann Pharm Fr 1983;41(2):151
N-methylpapaverine  2679-26-7 Isoquinolinium, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-2-methyl-, iodide  Papaverine/*analogs & derivatives. J Nat Prod 1983;46(2):226
1-(4-aminophenyl)isoquinoline  58992-84-0   Papaverine/*analogs & derivatives. J Med Chem 1983;26(2):174
1-(4-aminobenzyl)isoquinoline  42398-69-6   Papaverine/*analogs & derivatives. J Med Chem 1983;26(2):174
drotaverine, acephyllinate drug combination  61954-97-0   Drug Combinations Papaverine/*analogs & derivatives Theophylline/*analogs & derivatives. Acta Vet Acad Sci Hung 1981;29(2):173
spasmofen  82824-08-6 Morphinan 3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-, hydrochloride, mixt. with (5alpha,6alpha)-7,8-didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol hydrochloride, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxyisoquinoline hydrochl  *Codeine *Morphine *Noscapine *Papaverine *Scopolamine Derivatives Drug Combinations. Lancet 1982;1(8281):1096
Pencardin  80186-95-4 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-phenyl-, mixt. with 2,2-bis(hydroxymethyl)-1,3-propanediol, 1-((3,4-diethoxyphenyl)methylene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride and 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione compd. wi  *Aminophylline *Phenobarbital *Propylene Glycols Drug Combinations Papaverine/*analogs & derivatives. Pneumonol Pol 1981;49(1):43
Migraine-Kranit  77193-78-3 Acetamide, N-(4-hydroxyphenyl)-, mixt. with 1-((3,4-diethoxyphenyl)methyl)-6,7-diethoxyisoquinoline hydrochloride, 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3H-pyrazol-3-one, 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione and 5-ethyl-5-phenyl  *Acetaminophen *Caffeine *Phenobarbital Antipyrine/*analogs & derivatives Drug Combinations Papaverine/*analogs & derivatives. Arzneim Forsch 1981;31(1):105
Myocardon  0   *Aminophylline *Atropine *Nitroglycerin *Papaverine *Phenobarbital Drug Combinations. ZFA (Stuttgart) 1980;56(7):511
3-azapapaverine  10089-99-3 Phthalazine, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy  Papaverine/*analogs & derivatives. J Pharm Sci 69(1):120;1980
6'-bromodihydropapaverine  41823-67-0 1-((2-bromo-4,5-dimethoxyphenyl)methyl)-3,4-dihydro-6,7-dimethoxyisoquinoline  Papaverine/*analogs & derivatives. Acta Physiol Pharmacol Bulg 1979;5(3):82
6'-iododihydropapaverine  0   Papaverine/*analogs & derivatives. Acta Physiol Pharmacol Bulg 1979;5(3):82
3,4-dihydropapaverine  6957-27-3 1-(3,4-dimethoxyphenylmethyl)-3,4-dihydro-6,7-dimethoxyisoquinoline  Papaverine/*analogs & derivatives. Acta Physiol Pharmacol Bulg 1979;5(3):82
succinyltrimethylpapaveroline  0   Papaverine/*analogs & derivatives. Biochemistry 17(16):3297;1978
Spasmo-Bilicura  0   *Plant Extracts *Scopolamine Hydrobromide Drug Combinations Papaverine/*analogs & derivatives. Fortschr Med 95(47-48):2829;1977
quarelin  62201-28-9   *Dipyrone Drug Combinations Papaverine/*analogs & derivatives. Ther Hung 25(1):32;1977
papaverine codecarboxylate  56896-69-6   Papaverine/*analogs & derivatives. Phlebologie 28(4):9;1975
papaverine adenylate  39024-96-9   Papaverine/*analogs & derivatives. Sem Hop Paris 50(10):661;1975
Hylakombun  77572-85-1 Pancreatin, mixt. with 5,7-dichloro-8-quinolinol and 1-((3,4-diethoxyphenyl)methyl)-6,7-diethoxyisoquinoline hydrochloride  *Hydroxyquinolines *Pancreatin *Papaverine Drug Combinations. Wien Med Wochenschr Suppl 25:1;1975
diprosine  0   Papaverine/*analogs & derivatives Parasympatholytics. Digestion 11(1-2):72;1974
Broncho-binotal  63952-75-0 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((aminophenylacetyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta(S*)))-, mixt. with 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxyisoquinoline hyd  *Ampicillin *Guaifenesin *Papaverine *Theophylline Drug Combinations Bronchitis/drug therapy. Arzneim Forsch 24(12):2035;1974
ethaverine  486-47-5 6,7-diethoxy-1-(3,4-diethoxybenzyl)isoquinoline  Papaverine/*analogs & derivatives.
Pharma Action Parasympatholytics 		Arch Int Pharmacodyn Ther 221(1):163;1976; Arzneim Forsch 28(5):794;1978; C R Soc Biol (Paris) 171(1):214;1977; C R Soc Biol (Paris) 171(5):1075;1977; Curr Ther Res 16(10):1096;1974; Fortschr Med 95(47-48):2829;1977; J Pharmacol Exp Ther 204(3):645;1978
drotaverin  14009-24-6 1-benzyl-3',4',6,7-tetraethoxy-1,2,3,4- tetrahydroisoquinoline  Papaverine/*analogs & derivatives.
Pharma Action Analgesics ; Parasympatholytics ; Vasodilator Agents 		Acta Med Acad Sci Hung 31(3-4):157;1974; Acta Pharm Hung 48(suppl):13;1979; Acta Pharm Hung 49(2):50;1979; Acta Physiol Acad Sci Hung 1979;53(3):369; Basic Res Cardiol 71(3):264;1976; Eur J Drug Metab Pharmacokinet 1979;4(4):213; Farm Z 5:88;1977; Farmakol Toksikol 38(3):324;1975; Farmakol Toksikol 39(3):304;1976; Farmakol Toksikol 40(5):547;1977; Fiziol Zh 24(3):366;1978; Fiziol Zh 61(10):1539;1975; Khirurgiia 10:85;1978; Pharm Acta Helv 1979;54(12):363; Pharm Acta Helv 1979;54(7-8):210; Pharmazie 30(3):174;1975; Vestn Oftalmol 2:71;1978; Vestn Oftalmol 5:68;1976; Vrach Delo 2:60;1977; Vrach Delo 3:13;1977
moxaverine  10539-19-2 1-benzyl-3-ethyl-6,7-dimethoxyisoquinoline  Papaverine/*analogs & derivatives.
Pharma Action Parasympatholytics 		Arzneim Forsch 26(4b):693;1976; Eksp Med Morfol 14(4):182;1975; Ther Ggw 116(7):1348;1977
Eutergine  0   *Dihydroergotoxine *Papaverine *Sparteine Drug Combinations Cerebrovascular Disorders/drug therapy. Lille Med 17(5):819;1972
L 989  0   *Dimethylpolysiloxanes *Enzymes *Papaverine Drug Combinations. Rev Bras Med 29(5):258;1972
Dilpavan  76391-74-7 D-Ascorbic acid, mixt. with (E)-1-(4-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2-hydroxy-6-methoxyphenyl)-3-(3-hydroxy-4-methoxyphenyl)-2-propen-1-one, 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxyisoquinoline hydrochloride and 5  *Flavonoids *Papaverine *Pyridoxine Drug Combinations. Bordeaux Med 4(10):2921;1971

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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