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Pepsin A

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Definition: Formed from pig pepsinogen by cleavage of one peptide bond. The enzyme is a single polypeptide chain and is inhibited by methyl 2-diaazoacetamidohexanoate. It cleaves peptides preferentially at the carbonyl linkages of phenylalanine or leucine and acts as the principal digestive enzyme of gastric juice.  /biosyn /physiol permitted   
Pharmacological Action Gastrointestinal Agents 		Other names Pepsin; Pepsin 3; Pepsin 1
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
pepsin inhibitor PI-3  0   *Helminth Proteins Pepsin A/antagonists & inhibitors. FEBS Lett 2000 Jun 2;474(2-3):252-6
pepsin B  EC 3.4.23.2   *Pepsin A. Arch Biochem Biophys 1995 Oct 1;322(2):417-22
ecabet  33159-27-2   *Diterpenes, Abietane Pepsin A/antagonists & inhibitors.
Pharma Action Anti-Infective Agents ; Anti-Ulcer Agents ; Protease Inhibitors ; Anticarcinogenic Agents 		Jpn J Pharmacol 1989;51(1):65
phenylalanyl-glycyl-valyl-statyl-alanyl-phenylalanine methyl ester  112317-46-1   *Oligopeptides Pepsin A/antagonists & inhibitors. J Med Chem 1988;31(3):625
phenylalanyl-glycyl-histidyl-statyl-alanyl-phenylalanine methyl ester  112317-45-0   *Oligopeptides Pepsin A/antagonists & inhibitors. J Med Chem 1988;31(3):625
H 256  100111-08-8 L-Glutamic acid, N-(N2-(N-(3-phenyl-2-((N-(N-L-prolyl-L-threonyl)-L-alpha-glutamyl)amino)propyl)-L-phenylalanyl)-L-arginyl)-, (S)  *Oligopeptides Pepsin A/antagonists & inhibitors. Biochem Soc Trans 1987;15(4):751
valyl-leucyl-prolyl-phenylalanyl-phenylalanyl-valyl-leucine  91269-93-1 D-Leucine, N-(N-(N-(N-(1-(N-L-valyl-D-leucyl)-L-prolyl)-L-phenylalanyl)-L-phenylalanyl)-L-valyl)-, (E)  *Oligopeptides Pepsin A/antagonists & inhibitors. Anal Biochem 1984;139(2):265
diazoacetylglycine ethyl ester-pepsin  0   Glycine Pepsin A. Can J Biochem 1979;57(8):1090
gastricsin  EC 3.4.23.3   *Pepsin A. Biochem Biophys Res Commun 63(4):1106;1975
Streptomyces pepsin inhibitor  11076-29-2   *Pepstatins Pepsin A/antagonists & inhibitors Hydroxyl Radical Proteinase Inhibitory Proteins, Secretory. Biochim Biophys Acta 452(2):521;1976; J Biochem (Tokyo) 1980;87(2):573
spasmocanulase  79173-12-9 D-Glutamic acid, hydrochloride, mixt. with cellulose, dimethicone, 1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine hydrochloride, pancreatin, pepsin A and sodium (5beta)-3,7,12-trioxocholan-24-oate  *Dehydrocholic Acid *Dimethylpolysiloxanes *Glutamates *Pancreatin *Pepsin A *Thioxanthenes Drug Combinations. S Afr Med J 48(53):2205;1974
diskilene  76403-97-9 Pancreatin, mixt. with 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide monohydrochloride, oxybis(butanol) and pepsin A  *Ethers *Metoclopramide *Pancreatin *Pepsin A *Silicones Drug Combinations. Clin Terap 78:253;1976; Clin Terap 84:491;1978; Rev Esp Enferm Apar Dig 44(2):187;1974
pepstanone A  38752-31-7   *Pepstatins Pepsin A/antagonists & inhibitors. J Antibiot 25(8):489;1972; Proteases Biol Control W3 C162N:439;1975

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