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Peptide Hydrolases

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Definition: Hydrolases that specifically cleave the peptide bonds found in PROTEINS and PEPTIDES. Examples of sub-subclasses for this group include EXOPEPTIDASES and ENDOPEPTIDASES.     
Examples Aspartic Acid Proteases; ATP-Dependent Proteases; Cathepsins; Cysteine Proteases; Endopeptidases; Exopeptidases; Metalloproteases; Proprotein Convertases; Proteasome Endopeptidase Complex; Serine Proteases 		Other names Proteolytic Enzymes; Proteinases; Proteases; Peptidases; Esteroproteases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ALV003  EC 3.4.-   *Peptide Hydrolases Celiac Disease/drug therapy. Dig Dis Sci. 2012 Feb;57(2):440-50
ERMP1 protein, human  EC 3.4.-   *Peptide Hydrolases. Oncogene. 2012 Jan 19;31(3):333-41.
TRY-5 protein, C elegans  EC 3.4.-   *Peptide Hydrolases *Caenorhabditis elegans Proteins Seminal Plasma Proteins. PLoS Genet. 2011 Nov;7(11):e1002375.
48-kDa protease, Artocarpus heterophyllus  EC 3.4.-   *Peptide Hydrolases. Eur Rev Med Pharmacol Sci. 2012 Jan;16(1):132-7
SepA protein, E coli  EC 3.4.-   *Peptide Hydrolases *Escherichia coli Proteins Virulence Factors. J Infect Dis. 2012 Feb;205(3):431-44.
ROM4 protein, Toxoplasma gondii  EC 3.4.-   *Peptide Hydrolases *Protozoan Proteins. Med Sci (Paris). 2011 Jun-Jul;27(6-7):576-8
Aph1b protein, rat  EC 3.4.-   *Membrane Proteins *Peptide Hydrolases.
Aph1a protein, rat  EC 3.4.-   *Membrane Proteins *Peptide Hydrolases.
Arxes2 protein, mouse  EC 3.4.-   *Peptide Hydrolases. Nucleic Acids Res 2011 Apr;39(8):3224-39
Arxes1 protein, mouse  EC 3.4.-   *Peptide Hydrolases. Nucleic Acids Res 2011 Apr;39(8):3224-39
Losac protein, Lonomia obliqua  EC 3.4.-   *Peptide Hydrolases *Insect Proteins Factor X/agonists. J Biol Chem 2011 Mar 4;286(9):6918-28
FSAP protein, rat  0   *Peptide Hydrolases. Int J Mol Med 2010 Oct;26(4):549-55
SENP6 protein, rat  EC 3.4.-   *Peptide Hydrolases. J Androl 2010 Jul-Aug;31(4):406-18
SLC7A6OS protein, human  0   *Peptide Hydrolases. BMB Rep 2010 May;43(5):375-81
eumiliin, Euphorbia milii  EC 3.4.-   *Peptide Hydrolases. Phytochemistry. 2010 May;71(7):708-15
CRBN protein, zebrafish  EC 3.4.-   *Peptide Hydrolases *Zebrafish Proteins. Science. 2010 Mar 12;327(5971):1345-50
SPC1 protein, S cerevisiae  0   *Peptide Hydrolases *Saccharomyces cerevisiae Proteins.
SpyCEP protein, Streptococcus pyogenes  EC 3.4.-   *Peptide Hydrolases. J Infect Dis 2005 Sep 1;192(5):783-90
ClpX protein, Campylobacter jejuni  EC 3.4.-   *Peptide Hydrolases. Appl Environ Microbiol 2007 Dec;73(24):7803-13
ClpA protein, Campylobacter jejuni  EC 3.4.-   *Peptide Hydrolases. Appl Environ Microbiol 2007 Dec;73(24):7803-13
DUG2 protein, S cerevisiae  EC 3.4.-   *Peptide Hydrolases *Saccharomyces cerevisiae Proteins. Genetics 2007 Mar;175(3):1137-51
CSN4 protein, Drosophila  EC 3.4.-   *Peptide Hydrolases. Mol Biol Cell 2007 Apr;18(4):1179-86
Avizyme 1502  0   *Amylases *Peptide Hydrolases *Endo-1,4-beta Xylanases Dietary Supplements. Poult Sci. 2007 Mar;86(3)
Gcp glycoprotease, Staphylococcus aureus  EC 3.4.-   *Peptide Hydrolases. FEMS Microbiol Lett 2005 Apr 15;245(2):279-85
ALTU-135  EC 3.-   *Amylases *Lipase *Peptide Hydrolases. J Pediatr 2006 Nov;149(5):658-662
ROM4 protein, Plasmodium falciparum  EC 3.4.-   *Peptide Hydrolases *Protozoan Proteins. J Cell Biol 2006 Sep 25;174(7):1023-33
PrtV protein, Vibrio cholerae  EC 3.4.-   *Peptide Hydrolases. Proc Natl Acad Sci U S A 2006 Jun 13;103(24):9280-5
Senp5 protein, human  EC 3.4.-   *Peptide Hydrolases. J Biol Chem 2006 Jun 9;281(23):15869-77
presequence protease PreP, Arabidopsis  EC 3.4.-   *Peptide Hydrolases *Arabidopsis Proteins. EMBO J 2006 May 3;25(9):1977-86
tropolysin, Trypanosoma  EC 3.4.-   *Peptide Hydrolases *Protozoan Proteins. Biochemistry 2005 Nov 8;44(44):14658-69
microfilarial protease, Brugia malayi  EC 3.4.-   *Peptide Hydrolases. Indian J Exp Biol 2005 Sep;43(9):759-68
AVP protein, Human adenovirus type 2  EC 3.4.-   *Peptide Hydrolases Viral Proteins. Biochemistry 2005 Jun 21;44(24):8721-9
CRBN protein, human  EC 3.4.-   *Peptide Hydrolases. Neurology 2004 Nov 23;63(10):1927-31
PrePII protein, Arabidopsis  EC 3.4.-   *Peptide Hydrolases *Arabidopsis Proteins. J Mol Biol 2005 Jun 17;349(4):847-60
PrePI protein, Arabidopsis  EC 3.4.-   *Peptide Hydrolases *Arabidopsis Proteins. J Mol Biol 2005 Jun 17;349(4):847-60
CSN5 protein, Drosophila  EC 3.4.-.-   *Peptide Hydrolases *Intracellular Signaling Peptides and Proteins.
Cops5 protein, mouse  EC 3.4.-.-   *Peptide Hydrolases *Intracellular Signaling Peptides and Proteins.
COPS5 protein, human  EC 3.4.-.-   *Peptide Hydrolases *Intracellular Signaling Peptides and Proteins.
ompT protein, E coli  0   *Bacterial Outer Membrane Proteins *Peptide Hydrolases *Escherichia coli Proteins.
Senp3 protein, mouse  EC 3.4.   *Peptide Hydrolases.
Stambpl1 protein, mouse  EC 3.4.19.-   *Peptide Hydrolases. Biochem Biophys Res Commun 2003 Sep 12;309(1):135-42
APH1B protein, human  EC 3.4.-   *Membrane Proteins *Peptide Hydrolases. Biochem Biophys Res Commun. 2003 Jun 6;305(3):502-9
APH1A protein, human  EC 3.4.-   *Membrane Proteins *Peptide Hydrolases. Biochem Biophys Res Commun. 2003 Jun 6;305(3):502-9
polyglutamyl gamma-hydrolase  EC 3.4.-   *Peptide Hydrolases. Biomacromolecules 2000 Spring;1(1):75-83
factor V activating enzyme  EC 3.4.-   *Peptide Hydrolases Coagulants Viper Venoms. Biochem Biophys Res Commun 1999 Aug 27;262(2):328-32
cyanophycinase  EC 3.4.-   *Peptide Hydrolases. Eur J Biochem 1999 Jul;263(1):163-9
DEVDase  EC 3.4.99.-   *Peptide Hydrolases Caspase 3. Oncogene 1997 Sep 25;15(13):1573-81
catalytin  0   *Quaternary Ammonium Compounds *Amylases *Peptide Hydrolases Enzymes, Immobilized. Antibio Khimioter 1997;42(3):11-4
SOM1 protein, S cerevisiae  0   *Peptide Hydrolases *Mitochondrial Proteins *Saccharomyces cerevisiae Proteins. Mol Gen Genet 1996 Sep 25;252(4):437-45
peptidase L1  EC 3.4.99.-   *Peptide Hydrolases. Biokhimiia 1996 Apr;61(4):656-63
PepB oligopeptidase, Streptococcus  EC 3.4.-   *Bacterial Proteins *Peptide Hydrolases. Infect Immun 1996 Aug;64(8):3401-6
protease I, Pyrococcus furiosus  EC 3.4.-   *Peptide Hydrolases *Recombinant Fusion Proteins *Archaeal Proteins Archaeal Proteins. J Bacteriol 1996 May;178(9):2605-12
pfaP protein, Leptospira borgpetersenii  EC 3.4.21.-   *Bacterial Proteins *Peptide Hydrolases. Gene 1995 Jul 4;160(1):133-4
COP9 signalosome complex  0   *Peptide Hydrolases *Multiprotein Complexes. Cell 1994 Jul 15;78(1):117-24
p80 protein, bovine viral diarrhea virus  156532-58-0   *Peptide Hydrolases *Viral Nonstructural Proteins *RNA Helicases. J Virol 1994 May;68(5):3289-97
Persil  0   Lipids *Peptide Hydrolases *Polyphosphates Surface-Active Agents. Int Endod J 1993 Nov;26(6):334-43
somilase  EC 3.-   *Amylases *Peptide Hydrolases. Eksp Klin Farmakol 1992 May-Jun;55(3):24-6
teralgim  0   *Alginates *Amylases *Peptide Hydrolases Drug Combinations. Stomatologiia (Mosk) 1991 Sep-Oct;(5):46-7
immozymase  EC 3.4.99.-   *Peptide Hydrolases Enzymes, Immobilized. Probl Tuberk 1991;(6):42-5
SpoIIGA protein, Bacillus subtilis  EC 3.4.23.-   *Bacterial Proteins *Membrane Proteins *Peptide Hydrolases. J Bacteriol 1991;173(24):7821
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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