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Endopeptidases

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Definition: A subclass of PEPTIDE HYDROLASES that catalyze the internal cleavage of PEPTIDES or PROTEINS.     
Examples Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; ATP-Dependent Endopeptidases; Brinolase; Coagulase; Cysteine Endopeptidases; Metalloendopeptidases; Serine Endopeptidases; Streptokinase 		Other names Peptide Peptidohydrolases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
USP46 protein, rat  EC 3.4.-   *Endopeptidases. PLoS One. 2011;6(10):e26297.
USP46 protein, mouse  EC 3.4.-   *Endopeptidases. Nat Genet. 2009 Jun;41(6):688-95.
AlpB endopeptidase, Lysobacter  EC 3.4.-   *Bacterial Outer Membrane Proteins *Endopeptidases. Dokl Biochem Biophys. 2011 Nov-Dec;441():298-301
Rpn11 protein, Drosophila  EC 3.4.-   *Endopeptidases *Drosophila Proteins. Exp Gerontol. 2012 Feb;47(2):170-8
TRABID protein, human  EC 3.4.-   *Endopeptidases. Biochem J. 2001 Aug 1;357(Pt 3):617-23.
SENP-1 protein, rat  EC 3.4.-   *Endopeptidases. J Cereb Blood Flow Metab. 2012 Jan;32(1):17-22
MYSM1 protein, mouse  EC 3.4.99.-   *Endopeptidases. Immunity. 2011 Dec 23;35(6):883-96
inner mitochondrial membrane peptidase 2-like protein, mouse  EC 3.4.-   *Endopeptidases *Mitochondrial Proteins Membrane Proteins. Aging Cell. 2011 Aug;10(4):584-94.
katanin-like 1 protein, human  EC 3.4.-   *Endopeptidases. Cell Cycle 2010 Jun 15;9(12):2403-11
ubiquitin-specific peptidase 46, human  EC 3.4.-   *Endopeptidases. J Hum Genet 2010 Mar;55(3):133-6
USP13 protein, human  EC 3.4.-   *Endopeptidases. J Biol Chem 2011 Aug 5;286(31):27333-41
UBP13 protein, Arabidopsis  EC 3.4.99.-   *Endopeptidases *Arabidopsis Proteins. New Phytol 2011 Jul;191(1):92-106
UBP12 protein, Arabidopsis  EC 3.4.99.-   *Endopeptidases *Arabidopsis Proteins. New Phytol 2011 Jul;191(1):92-106
Ubp15 protein, S cerevisiae  EC 3.4.99.-   *Endopeptidases *Saccharomyces cerevisiae Proteins. Biochemistry 2011 Jul 26;50(29):6423-32
deubiquitinase USP37, human  EC 3.4.99.-   *Endopeptidases. Mol Cell. 2011 May 20;42(4):511-23
USP19 protein, human  EC 3.4.-   *Endopeptidases. EMBO Rep 2009 Jul;10(7):755-61
ovarian tumor domain-containing 6B protein, human  EC 3.4.-   *Endopeptidases. PLoS One 2011;6(1):e14514
Cops6 protein, zebrafish  EC 3.4.-   *Endopeptidases *Zebrafish Proteins. Int J Dev Biol 2011;55(1):19-24
USP46 protein, Xenopus  EC 3.4.-   *Endopeptidases *Xenopus Proteins. J Biol Chem 2011 Mar 4;286(9):7190-201
USP12 protein, Xenopus  EC 3.4.-   *Endopeptidases *Xenopus Proteins. J Biol Chem 2011 Mar 4;286(9):7190-201
ATXN3L protein, human  EC 3.4.19.12   *Endopeptidases. J Biol Chem 2011 Feb 11;286(6):4555-65
Usp39 protein, zebrafish  EC 3.4.-   *Endopeptidases *Zebrafish Proteins. PLoS Genet 2011;7(1):e1001271
USP6 protein, mouse  EC 3.4.-   *Endopeptidases. J Biol Chem 2010 Nov 19;285(47):37111-20
purpurase protein, Cryptelytrops purpureomaculatus  EC 3.4.-   *Crotalid Venoms *Endopeptidases. Comp Biochem Physiol C Toxicol Pharmacol 2010 Jan;151(1):131-6
L-alanoyl-D-glutamate peptidase, bacteriophage T5  EC 3.4.99.-   *Endopeptidases *Viral Proteins. FEBS J. 2009 Dec;276(24):7329-42
BA1952 protein, Bacillus anthracis  EC 3.4.-   *Bacterial Proteins *Endopeptidases. Appl Environ Microbiol. 2009 Oct;75(19):6157-67
Usp8 protein, mouse  0   *Endopeptidases *Ubiquitin Thiolesterase *Endosomal Sorting Complexes Required for Transport.
USP8 protein, human  0   *Endopeptidases *Ubiquitin Thiolesterase *Endosomal Sorting Complexes Required for Transport. Trends Biochem Sci. 2007 Dec;32(12):561-73
ubiquitin specific protease 36, Drosophila  EC 3.4.99.-   *Endopeptidases *Drosophila Proteins. Science 2009 Jan 9;323(5911):248-51
SENP7 protein, human  EC 3.4.22.-   *Endopeptidases. J Biol Chem 2008 Nov 14;283(46):32045-55
Usp30 protein, human  EC 3.1.2.15   *Thiolester Hydrolases *Mitochondrial Proteins Endopeptidases. Mol Biol Cell 2008 May;19(5):1903-11
taspase1, Drosophila  EC 3.4.22.-   *Drosophila Proteins *Endopeptidases. Mol Cell Biol 2007 Oct;27(20):7063-72
yjgB protein, Lactococcus lactis  EC 3.4.99.-   *Endopeptidases. Appl Environ Microbiol 2007 Sep;73(18):5825-31
deubiquitinating enzyme A, human  EC 3.4.-   *Endopeptidases. Science 2007 Dec 7;318(5856):1628-32
MV-L lysin, bacteriophage phiMR11  EC 3.4.99.-   *Endopeptidases. J Infect Dis 2007 Oct 15;196(8):1237-47
USP-33 protein, rat  EC 3.4.-   *Endopeptidases. Endocrinology 2007 Oct;148(10):4865-74
Pros26 protein, Drosophila  EC 3.4.-   *Endopeptidases *Drosophila Proteins. Genetics 2006 Jul;173(3):1377-87
Prosbeta2 protein, Drosophila  EC 3.4.-   *Endopeptidases *Drosophila Proteins. Genetics 2006 Jul;173(3):1377-87
Pros25 protein, Drosophila  EC 3.4.-   *Endopeptidases Protein Subunits. Biochim Biophys Acta 1993 Aug 19;1174(2):215-7
taspase1, mouse  EC 3.4.22.-   *Endopeptidases. Genes Dev 2006 Sep 1;20(17):2397-409
AESP protein, Arabidopsis  EC 3.4.22.49   *Endopeptidases *Cell Cycle Proteins. Plant Cell 2006 May;18(5):1213-25
xFAM protein, Xenopus  EC 3.4.99.-   *Endopeptidases *Xenopus Proteins Ubiquitins. Science. 2005 Dec 2;310(5753):1499-504
N(pro) protein, swine fever virus  EC 3.4.-   *Endopeptidases *Viral Proteins. Virology 2005 Sep 30;340(2):265-76
Usp7 protein, rat  EC 3.4.99.-   *Endopeptidases. FEBS Lett 2005 Aug 29;579(21):4867-72
Bre5 protein, S cerevisiae  EC 3.4.99.-   *Endopeptidases *Saccharomyces cerevisiae Proteins. J Biol Chem 2005 Aug 12;280(32):29176-85
UBP8 protein, S cerevisiae  EC 3.4.99.-   *Endopeptidases. Mol Cell Biol 2005 Jul;25(14):6123-39
Senp1 protein, mouse  EC 3.4.-   *Endopeptidases. Mol Cell Biol 2005 Jun;25(12):5171-82
RN-tre protein, Drosophila  EC 3.4.99.-   *Endopeptidases *Drosophila Proteins.
Aph1C protein, mouse  EC 3.4.99.-   *Endopeptidases. Proc Natl Acad Sci U S A 2005 Feb 1;102(5):1719-24
Aph1b protein, mouse  EC 3.4.99.-   *Endopeptidases. Proc Natl Acad Sci U S A 2005 Feb 1;102(5):1719-24
Aph1a protein, mouse  EC 3.4.99.-   *Endopeptidases. Proc Natl Acad Sci U S A 2005 Feb 1;102(5):1719-24
lonofibrase  EC 3.4.-   *Endopeptidases. Thromb Res 2004;113(2):147-54
myulchikinase  EC 3.4.99.-   *Endopeptidases. Biotechnol Lett 2004 Mar;26(5):393-7
UBP14 protein, Arabidopsis  0   *Endopeptidases *Arabidopsis Proteins.
RCE1 protein, human  EC 3.4.22   *Endopeptidases Lipoproteins Protein Processing, Post-Translational.
Rce1 protein, mouse  EC 3.4.22   *Endopeptidases Protein Processing, Post-Translational.
AtUBP3 protein, Arabidopsis  EC 3.4.-   *Endopeptidases *Arabidopsis Proteins.
trypanolysin protein, Schistocerca gregaria  EC 3.4.-   *Endopeptidases *Insect Proteins *Lectins. East Afr Med J 2003 Nov;80(11):575-80
SENP1b protein, Xenopus  EC 3.4.-   *Endopeptidases *Xenopus Proteins. Genes Cells 2004 Aug;9(8):723-36
SENP1a protein, Xenopus  EC 3.4.-   *Endopeptidases *Xenopus Proteins. Genes Cells 2004 Aug;9(8):723-36
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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