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Peptide Synthases

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Definition: Ligases that catalyze the joining of adjacent AMINO ACIDS by the formation of carbon-nitrogen bonds between their carboxylic acid groups and amine groups.     
Examples Glutamate-Cysteine Ligase; Glutathione Synthase 		Other names Peptide Synthetases; Synthetases, Peptide; Synthases, Peptide; Ligases, Acid-Amino-Acid; Acid Amino Acid Ligases; Acid-Amino-Acid Ligases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MurE protein, Mycobacterium tuberculosis  EC 6.3.2.13   *Bacterial Proteins *Peptide Synthases. J Antimicrob Chemother. 2010 Oct;65(10):2101-7
TTLL12 protein, human  EC 6.3.2.-   *Peptide Synthases. Int J Cancer 2010 Dec 1;127(11):2542-53
paics protein, zebrafish  0   *Carboxy-Lyases *Peptide Synthases *Zebrafish Proteins. Development. 2009 Aug;136(15); 2601-11
Ttll3 protein, zebrafish  EC 6.3.2.-   *Peptide Synthases *Zebrafish Proteins. Dev Cell 2009 Jun;16(6):867-76
epsilon-poly-L-lysine synthethase, Streptomyces albulus  EC 6.3.2.-   *Peptide Synthases. Nat Chem Biol 2008 Dec;4(12):766-72
Ade5 protein, Candida albicans  EC 4.1.1.21   *Carboxy-Lyases *Peptide Synthases. Microbiology 2007 Jul;153(Pt 7):2351-62
Atg3 protein, rat  EC 6.3.2.-   *Peptide Synthases. Mol Vis 2006;12:1292-302
Pes1 protein, Aspergillus fumigatus  EC 6.3.2.   *Fungal Proteins *Peptide Synthases. FEBS 2006 Jul;273(13):3038-53
TTLL6 protein, human  EC 6.3.2.-   *Peptide Synthases. Gene 2006 Mar 29;370:58-63
folC protein, E coli  EC 6.3.2.-   *Multienzyme Complexes *Peptide Synthases *Escherichia coli Proteins.
Dfp protein, E coli  0   *Carboxy-Lyases *Multienzyme Complexes *Peptide Synthases *Escherichia coli Proteins.
3,4-dihydroxy-2-butanone 4-phosphate synthase, C albicans  EC 6.3.2.   *Peptide Synthases. J Mol Biol. 2004 Aug 20;341(4):1085-96
arthrofactin synthetase  EC 6.3.2.-   *Peptide Synthases. Chem Biol 2003 Sep;10(9):869-80
FemX UDP-MurNAc-pentapeptide l-alanine ligase  EC 6.3.2.-   *Peptide Synthases. Acta Crystallogr D Biol Crystallogr. 2003 Jun;59(Pt 6):1055-7
penicillin-binding protein 2a, Streptococcus  0   *Peptide Synthases *Penicillin-Binding Proteins.
IndC protein, Erwinia chrysanthemi  EC 6.3.2.-   *Bacterial Proteins *Peptide Synthases. J Bacteriol 2002 Feb;184(3):654-65
gamma-polyglutamic acid synthetase  EC 6.3.2.-   *Peptide Synthases. J Bacteriol 2002 Jan;184(2):337-43
Psy1 protein, Trichoderma virens  EC 6.3.2.-   *Fungal Proteins *Peptide Synthases. Appl Environ Microbiol 2001 Nov;67(11):5055-62
microcystin synthetase A  EC 6.3.2.-   *Bacterial Proteins *Peptide Synthases Microcystins. Appl Environ Microbiol 2001 Jun;67(6):2810-8
Sid2 protein, Ustilago maydis  EC 6.3.2.-   *Fungal Proteins *Peptide Synthases. J Bacteriol 2001 Jul;183(13):4040-51
AM-toxin synthetase  EC 6.3.2.-   *Peptide Synthases. Mol Plant Microbe Interact 2000 Jul;13(7):742-53
PFSYN depsipeptide synthetase  EC 6.3.2.-   *Peptide Synthases Depsipeptides. J Biol Chem 2000 Jun 9;275(23):17909-15
ade5 protein, Drosophila  EC 4.1.1.21   *Carboxy-Lyases *Peptide Synthases *Drosophila Proteins. Genetics 2000 Mar;154(3):1239-53
MurN protein, Streptococcus pneumoniae  EC 6.3.2.-   *Bacterial Proteins *Peptide Synthases. Proc Natl Acad Sci U S A 2000 Apr 25;97(9):4891-6
MurM protein, Streptococcus pneumoniae  EC 6.3.2.-   *Bacterial Proteins *Peptide Synthases. Proc Natl Acad Sci U S A 2000 Apr 25;97(9):4891-6
VibF protein, bacteria  EC 6.3.2.-   *Bacterial Proteins *Peptide Synthases. J Bacteriol 2000 Mar;182(6):1731-8
MbtB protein, Mycobacterium tuberculosis  EC 6.3.2.-   *Bacterial Proteins *Peptide Synthases. Chem Biol 1998 Nov;5(11):631-45
homoglutathione synthase  EC 6.3.2.23   *Peptide Synthases. Plant Physiol 1999 Nov;121(3):753-61
aryl-4,2-bisthiazoline synthetase, Pseudomonas aeruginosa  EC 6.3.2.-   *Bacterial Proteins *Peptide Synthases. Biochemistry 1999 Nov 9;38(45):14941-54
VanD protein, Enterococcus faecium  EC 6.3.2.4   *Bacterial Proteins *Peptide Synthases. J Infect Dis 1999 Oct;180(4):1177-85
subtiligase  EC 6.3.2.-   *Peptide Synthases *Subtilisins. Biochem Biophys Res Commun 1999 Jan 8;254(1):147-51
FxbB protein, Mycobacterium smegmatis  EC 6.3.2.-   *Bacterial Proteins *Peptide Synthases. Mol Microbiol 1998 Jul;29(2):629-39
FxbC protein, Mycobacterium smegmatis  EC 6.3.2.-   *Bacterial Proteins *Peptide Synthases. Mol Microbiol 1998 Jul;29(2):629-39
cyanophycin synthase, bacteria  EC 6.3.2.-   *Bacterial Proteins *Peptide Synthases. Eur J Biochem 1998 May 15;254(1):154-9
tubulin polyglutamylase  EC 6.3.2.-   *Peptide Synthases Polyglutamic Acid Tubulin. Biochemistry 1998 Jun 9;37(23):8395-404
fengycin synthetase  EC 6.3.2.-   *Peptide Synthases. J Bacteriol 1998 Mar;180(5):1338-41
VanC protein, Enterococcus  EC 6.3.2.-   *Bacterial Proteins *Peptide Synthases Drug Resistance, Microbial. Proc Natl Acad Sci U S A 1997 Sep 16;94(19):10040-4
APS protein, Amycolatopsis mediterranei  EC 6.3.2.-   *Bacterial Proteins *Peptide Synthases. J Biotechnol 1997 Aug 11;56(2):115-28
pipecolate-incorporating enzyme, Streptomyces  EC 6.3.2.-   *Bacterial Proteins *Peptide Synthases. Eur J Biochem 1997 Jul 15;247(2):526-34
lysergyl peptide synthetase  EC 6.3.2.-   *Peptide Synthases. J Biol Chem 1996 Nov 1;271(44):27524-30
non-ribosomal peptide synthase  EC 6.3.2.-   *Peptide Synthases. Mol Gen Genet 1997 Jan 27;253(4):415-27
pristinamycin I synthetase  EC 6.3.2.-   *Peptide Synthases Multienzyme Complexes. J Bacteriol 1997 Feb;179(3):697-704
L-phenylglycine-AMP ligase  EC 6.3.2.-   *Bacterial Proteins *Peptide Synthases. J Bacteriol 1997 Feb;179(3):697-704
4-dimethylamino-L-phenylalanine thioester N-methylating enzyme  EC 6.3.2.-   *Bacterial Proteins *Peptide Synthases Multienzyme Complexes. J Bacteriol 1997 Feb;179(3):697-704
SnbC protein, Streptomyces pristinaespiralis  EC 6.3.2.-   *Bacterial Proteins *Peptide Synthases Multienzyme Complexes. J Bacteriol 1997 Feb;179(3):697-704
SnbA protein, Streptomyces pristinaespiralis  EC 6.3.2.-   *Bacterial Proteins *Peptide Synthases. J Bacteriol 1997 Feb;179(3):697-704
aspartic acid activating enzyme  EC 6.3.2.-   *Peptide Synthases. J Biol Chem 247(16):5095;1972
MAPEP1 protein, Microcystis aeruginosa  EC 6.3.2.-   *Bacterial Proteins *Peptide Synthases. FEMS Microbiol Lett 1996 Jan 15;135(2-3):295-303
SafA protein, Myxococcus xanthus  EC 6.3.2.-   *Bacterial Proteins *Peptide Synthases. Microbiology 1995 Aug;141( Pt 8):1793-803
alpha-aminoadipyl-cysteinyl-valine synthetase  EC 6.3.2.-   *Peptide Synthases. J Bacteriol 1986 Nov;168(2):947-52
SyrC protein, Pseudomonas syringae  EC 6.3.2.-   *Bacterial Proteins *Peptide Synthases. J Bacteriol 1995 Jul;177(14):4009-20
SYRB1 protein, Pseudomonas syringae  EC 6.3.2.-   *Bacterial Proteins *Peptide Synthases. J Bacteriol 1995 Jul;177(14):4009-20
pyoverdine synthetase protein, Pseudomonas  EC 6.3.2.-   *Bacterial Proteins *Peptide Synthases. J Bacterial 1995 Jan;177(1):252-8
SDZ 90-215 synthetase  EC 6.3.2.-   *Multienzyme Complexes *Peptide Synthases. Biochem Mol Biol Int 1993 Dec;31(5):797-805
PurC protein, Bacteria  EC 6.3.2.6   *Bacterial Proteins *Peptide Synthases. J Bacteriol 1993 Oct 1;175(19):6364-67
peptolide SDZ 214-103 synthetase  138576-33-7 Synthetase, peptolide  *Multienzyme Complexes *Peptide Synthases. J Biol Chem 1993 Sep 25;268(27):20452-65
HC-toxin synthetase 2  EC 6.3.2.-   *Amino Acid Isomerases *Peptide Synthases Ascomycota. J Biol Chem 1992 Dec 25;267(36):26044-9
lipoate-protein ligase  EC 6.3.2.-   *Peptide Synthases. FEBS Lett 1991;295(1-3):13
surfactin synthetase  EC 6.3.2.-   *Bacterial Proteins *Peptide Synthases. Biochemistry 1991;30(26):6503
pipecolate-activating enzyme  EC 6.3.2.-   *Peptide Synthases. Biochemistry 1991;30(23):5789
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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