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Phenylethanolamine N-Methyltransferase

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Definition: A methyltransferase that catalyzes the reaction of S-adenosyl-L-methionine and phenylethanolamine to yield S-adenosyl-L-homocysteine and N-methylphenylethanolamine. It can act on various phenylethanolamines and converts norepinephrine into epinephrine. (From Enzyme Nomenclature, 1992) EC 2.1.1.28.      Other names Phenethanolamine N-Methyltransferase; Phenylethanolamine N Methyltransferase; Phenethanolamine N Methyltransferase; Norepinephrine N Methyltransferase; Noradrenaline N Methyltransferase; Noradrenalin N Methyltransferase; Methyltransferase, Norepinephrine; Norepinephrine N-Methyltransferase; Norepinephrine Methyltransferase; Noradrenaline N-Methyltransferase; Noradrenalin N-Methyltransferase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-fluoromethyl-7-(3,3,3-trifluoropropylsulfonyl)-1,2,3,4-tetrahydroisoquinoline  0   *Sulfones *Isoquinolines Phenylethanolamine N-Methyltransferase/antagonists & inhibitors. J Med Chem 2006 Sep 7;49(18):5424-33
3-fluoromethyl-7-(N-3,3,3-trifluoropropylaminosulfonyl)-1,2,3,4-tetrahydroisoquinoline  0   *Isoquinolines *Sulfonamides Phenylethanolamine N-Methyltransferase/antagonists & inhibitors. J Med Chem 2005 Mar 24;48(6):1806-12
3-fluoromethyl-7-(N-2,2,2-trifluoroethylaminosulfonyl)-1,2,3,4-tetrahydroisoquinoline  0   *Isoquinolines *Sulfonamides Phenylethanolamine N-Methyltransferase/antagonists & inhibitors. J Med Chem 2005 Mar 24;48(6):1806-12
7-iodo-1,2,3,4-tetrahydroquinoline  0   *Quinolines Phenylethanolamine N-Methyltransferase/antagonists & inhibitors. J Med Chem 2004 Jan 1;47(1):37-44
3-chloromethyl-7-nitro-1,2,3,4-tetrahydroisoquinoline  0   *Tetrahydroisoquinolines Phenylethanolamine N-Methyltransferase/antagonists & inhibitors. J Med Chem 1999 Oct 21;42(21):4351-61
3-fluoromethyl-7-N-(4-chlorophenyl)aminosulfonyl-1,2,3,4-tetrahydroquinoline  0   *Isoquinolines Phenylethanolamine N-Methyltransferase/antagonists & inhibitors. J Med Chem 1999 Oct 21;42(21):4351-61
3-fluoromethyl-7-cyano-1,2,3,4-tetrahydroisoquinoline  0   *Tetrahydroisoquinolines Phenylethanolamine N-Methyltransferase/antagonists & inhibitors. J Med Chem 1999 Oct 21;42(21):4351-61
3-trifluoromethyl-7-bromo-1,2,3,4-tetrahydroisoquinoline  0   *Tetrahydroisoquinolines Phenylethanolamine N-Methyltransferase/antagonists & inhibitors. J Med Chem 1999 Aug 26;42(17):3315-23
3-trifluoromethyl-7-nitro-1,2,3,4-tetrahydroisoquinoline  0   *Tetrahydroisoquinolines Phenylethanolamine N-Methyltransferase/antagonists & inhibitors. J Med Chem 1999 Aug 26;42(17):3315-23
7-aminosulfonyl-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline  0   *Sulfonamides *Tetrahydroisoquinolines Phenylethanolamine N-Methyltransferase/antagonists & inhibitors. J Med Chem 1999 Jun 3;42(11):1982-90
4,9-dihydro-7-methoxy-3H-pyrido(3,4b)indole  31652-37-6   *Carbolines Phenylethanolamine N-Methyltransferase/antagonists & inhibitors. J Pharmacol Exp Ther 1990;252(1):117
4,5-dichloro-1-aminioindan  67236-34-4   *Indans Phenylethanolamine N-Methyltransferase/antagonists & inhibitors. Neurosci Lett 1987;83(1-2):138
2-cyclooctyl-2-hydroxyethylamine  57230-13-4   *Ethanolamines Phenylethanolamine N-Methyltransferase/antagonists & inhibitors. J Pharmacol Exp Ther 1982;223(2):375
8-chloro-tetrahydroisoquinoline-7-sulfonamide  81134-73-8 7-Isoquinolinesulfonamide, 8-chloro-1,2,3,4-tetrahydro  *Tetrahydroisoquinolines Phenylethanolamine N-Methyltransferase/antagonists & inhibitors. Endocrinology 1982;110(4):1102
1,2,3,4-tetrahydroisoquinoline-7-sulfonamide  31404-61-2 7-Isoquinolinesulfonamide, 1,2,3,4-tetrahydro  *Isoquinolines Phenylethanolamine N-Methyltransferase/antagonists & inhibitors. J Pharmacol 208(1):24;1979
7,8-dichloro-1,2,3,4-tetrahydroisoquinoline  57987-77-6   *Tetrahydroisoquinolines Phenylethanolamine N-Methyltransferase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors ; Monoamine Oxidase Inhibitors 		Arch Pharm (Naun Schmiedeberg) 299(3):219;1977; Can J Biochem 55(7):761;1977; Clin Pharmacol Ther 25(6):837;1979; Enzyme 22(6):371;1977; J Pharmacol Exptl Therap 197(3):623;1976; Life Sci 21(2):261;1977; Naunyn Schmiedeberg Arch Pharm 295(2):127;1976; Naunyn Schmiedeberg Arch Pharm 297(3):245;1977; Res Cancer Chem Pathol Pharm 17(2):201;1977
SK&F 9208A  52047-19-5 cyclopropanamine, 2-(2,5-dichlorophenyl)-, hydrochloride  *Propylamines Phenylethanolamine N-Methyltransferase/antagonists & inhibitors. Mol Pharmacol 9(6):718;1973
SK&F 7698  53464-65-6   *Pyridines Phenylethanolamine N-Methyltransferase/antagonists & inhibitors. Can J Biochem 55(7):761;1977; J Pharmacol Exp Ther 190(3):551;1974; Neurochem Res 3(1):15;1978; Science 191(4226):484;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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