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Phenethylamines

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Definition: A group of compounds that are derivatives of beta- aminoethylbenzene which is structurally and pharmacologically related to amphetamine. (From Merck Index, 11th ed)     
Examples Albuterol; Amphetamines; Butoxamine; Dexfenfluramine; Dimethoxyphenylethylamine; Dobutamine; Ephedrine; Fendiline; Fenfluramine; Hexoprenaline; 2-Hydroxyphenethylamine; Isoxsuprine; Mescaline; Methoxamine; p-Methoxy-N-methylphenethylamine; Nylidrin; Octopamine; Oxyfedrine; Prenylamine; Pseudoephedrine; Ritodrine; Selegiline; Suloctidil; Verapamil 		Other names Phenylethylamines
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4-ethyl-2,5-dimethoxyphenethylamine  0   *Phenethylamines Street Drugs. MMWR Morb Mortal Wkly Rep. 2012 Feb 10;61(5):85-8.
credneramide A  0   *Phenethylamines *Fatty Acids Neurotransmitter Agents. J Nat Prod. 2012 Jan 27;75(1):60-6
2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine  0   *Benzylamines *Phenethylamines Carbon Radioisotopes Ligands Receptor, Serotonin, 5-HT2A. J Nucl Med 2010 Nov;51(11):1763-70
N-allylidene-1,1-diphenylethanamine  0   *Phenethylamines. Org Lett. 2010 Aug 20;12(16):3571-3
N-((6-(methyloxy)-4'-(trifluoromethyl)-3-biphenylyl)methyl)-1-phenylethanamine  0   *Biphenyl Compounds *Phenethylamines. Eur J Pharmacol 2009 Aug 15;616(1-3):306-13
4'-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)ethyl)-3-methoxybiphenyl-4-carboxylic acid  0   *Biphenyl Compounds *Phenethylamines Receptors, Adrenergic, beta-3/agonists. Br J Pharmacol 2009 Jan;156(1):127-34
N,N-dimethyl-3,4-methylenedioxyphenethylamine  0   *Phenethylamines. J Psychoactive Drugs 2008 Jun;40(2):219-22
BVT116429  0   *Phenethylamines *Thiazoles. BMC Pharmacol. 2008;8() (dup#1):3
2-(2,5-dimethoxy-4-isopropylsulfanylphenyl)ethanamine  0   *Phenethylamines Psychoses, Substance-Induced Designer Drugs. Psychiatry Clin Neurosci 2008 Apr;62(2):243
phenoprolamine hydrochloride  0   *Phenethylamines. Biomed Chromatogr 2008 Mar;22(3):333-8
hostasinine A  0   *Phenethylamines Alkaloids. Org Lett. 2007 Dec 6;9(25):5279-81
meta-phenylene ethynylene  0   *Alkynes *Phenethylamines. Antimicrob Agents Chemother 2007 Nov;51(11):4125-32
2,5-dimethoxy-4-methylthiophenethylamine  0   *Phenethylamines. J Chromatogr A 2007 Aug 3;1159(1-2):198-202
2,5-dimethoxy-4-cyclohexylthiophenethylamine  0   *Phenethylamines. J Chromatogr A 2007 Aug 3;1159(1-2):198-202
2,5-dimethoxy-4-methyl-beta-phenethylamine  0   *Phenethylamines. J Mass Spectrom 2006 Nov;41(11):1509-19
N,N-dimethyl-1-phenethylamine  0   *Phenethylamines. Bioorg Med Chem. 2005 Apr 15;13(8):3047-55
2-dimethylamino-1-(4-hydroxyphenyl)-8,10-dimethyl-6-dodecene-3-one  0   *Ketones *Phenethylamines. J Antibiot (Tokyo) 2004 Sep;57(9):569-72
2,5-dimethoxy-4-n-propylthiophenethylamine  0   *Phenethylamines Substance-Related Disorders. J Anal Toxicol. 2003 Oct;27(7):493-8
1-phenylethylaminopyridine  0   *Phenethylamines *Pyridines. J Org Chem 2003 May 30;68(11):4527-30
2-(2-methylphenoxy)-1-phenylethanamine  0   *Phenethylamines *Phenyl Ethers. J Med Chem 2003 Nov 20;46(24):5238-48
N-acetyl-N-(2-(naphth-1-yloxy)ethyl)-4-methanesulfonamidophenethylamine  0   *Phenethylamines *Sulfonamides. J Med Chem 2002 Jul 4;45(14):2953-69
GYKI 16638  0   *Phenethylamines *Sulfonamides. Eur J Pharmacol 2000 Sep 15;404(1-2):181-90
hermitamide A  0   *Amides *Phenethylamines. J Nat Prod 2000 Jul;63(7):952-5
2-(N-methyl-N-(4-toluenesulfonyl)amino)-1-phenylpropan-1-ol  0   *Phenethylamines *Sulfonamides. Acta Crystallogr C 2000 Feb;56( Pt 2):227-8
KCB 328  0   *Phenethylamines *Sulfonamides Potassium Channels/antagonists & inhibitors. J Cardiovasc Pharmacol 1998 Apr;31(4):609-17
desmethylmebeverine alcohol  155172-67-1   *Phenethylamines. J Chromatogr B Biomed Appl 1996 Jul 12;602(2):273-81
aletamine  4255-23-6 alpha-2-propenyl benzeneethanamine  *Phenethylamines.
CT 435  0   *Phenethylamines. J Cell Sci 1994 Nov;107(Pt 11):3055-64
1-(2,5-dimethoxy-4-(trifluoromethyl)phenyl)-2-aminopropane  0   *Phenethylamines. J Med Chem 1994 Dec 9;37(25):4346-51
1,4-dihydro--2,6-dimethyl-4-(2-trifluoromethylphenyl)-3,5-pyridinedicarboxylic acid 2-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-3-(s-indacene)propionylamino)ethylethyl ester  0   *Dihydropyridines *Phenethylamines. Biochemistry 1994 Oct 4;33(39):11875-83
FPL 12495  118910-28-4   *Phenethylamines Stereoisomerism. Drug Metab Dispos 1994 May-Jun;22(3):443-6
4-dimethylaminophenethylamine  52632-05-0   *Phenethylamines. Life Sci 1994;54(25):1955-63
bamethan  3703-79-5 Benzenemethanol, alpha-((butylamino)methyl)-4-hydroxy  *Ethanolamines *Phenethylamines.
Pharma Action Vasodilator Agents
2-(N-n-3-fluoropropyl-N-(4-fluorophenyl)ethylamino)-5-hydroxytetralin  147703-11-5   *Phenethylamines *Tetrahydronaphthalenes Fluorine Radioisotopes. Appl Radiat Isot 1993 Mar;44(3):473-80
2-(N-n-3-fluoropropyl-N-(4-methylphenyl)ethylamino)-5-hydroxytetralin  147703-10-4   *Phenethylamines *Tetrahydronaphthalenes Fluorine Radioisotopes. Appl Radiat Isot 1993 Mar;44(3):473-80
1,2,3-tristriphenylethylaminopropane  144785-93-3   *Phenethylamines. Ukr Biokhim Zh 1992 Sep-Oct;64(5):100-3
RG 14893  141835-49-6   *Naphthols *Phenethylamines. J Med Chem 1992 Oct 30;35(22):4253-5
PD 136450  139067-52-0   *Indoles *Phenethylamines. Gastroenterology 1992 Nov;103(2):1596-601
mebeverine alcohol  14367-47-6   *Phenethylamines. Anal Chem 1992 Apr 1;64(7):802-6
14-debromoprearaplysillin I  136685-30-8   *Hydroxylamines *Phenethylamines. J Nat Prod 1991 Jul-Aug;54(4):1137-40
14-debromoaraplysillin I  136685-29-5 1-Oxa-2-azaspiro(4.5)deca-2,6,8-triene-3-carboxamide, N-(3-(4-(2-aminoethyl)-2-bromophenoxy)propyl)-7,9-dibromo-10-hydroxy-8-methoxy-, (5S-trans)  *Isoxazoles *Phenethylamines. J Nat Prod 1991 Jul-Aug;54(4):1137-40
araplysillin I  129313-98-0 1-Oxa-2-azaspiro(4.5)deca-2,6,8-triene-3-carboxamide, N-(3-(4-(2-aminoethyl)-2,6-dibromophenoxy)propyl)-7,9-dibromo-10-hydroxy-8-methoxy-, (5S-trans)  *Isoxazoles *Phenethylamines. J Nat Prod 1991 Jul-Aug;54(4):1137-40
5-amino-2,4-dihydroxy-alpha-methylphenylethylamine  106868-44-4   *Phenethylamines Neurotoxins. Pharmacol Biochem Behav 1991 Jul;39(3):737-42
5-(3-(3-(4,4-difluoro-5,7-dimethyl-3,4-diaza-4-bora-indacen-3-yl)propionamido)phenethyl-N-methylamino)-2-isopropyl-2-(3,4,5-trimethoxyphenyl)valeronitrile  139972-87-5   *Nitriles *Phenethylamines. J Biol Chem 1992 Feb 5;267(4):2179-89
1-(3-methoxy-4-methylphenyl)-2-aminopropane  87179-33-7   *Phenethylamines. J Med Chem 1991;34(5):1662
dofetilide  115256-11-6   *Phenethylamines *Sulfonamides.
Pharma Action Anti-Arrhythmia Agents ; Potassium Channel Blockers 		J Med Chem 1990;33(4):1151TIKOSYN
2-((2-aminoethylamino)carbonylethylphenylethylamino)-5'-N-ethylcarboxamidoadenosine  126828-50-0   *Phenethylamines Adenosine/*analogs & derivatives. FEBS Lett 1990;261(1):67
BRL 35135  91097-81-3   *Phenethylamines.
Pharma Action Adrenergic beta-Agonists 		Int J Obes 1989;13(6):757
podocarpamide  121880-09-9 2-Propenamide, 3-(1,3-benzodioxol-5-yl)-N-(2-(4-methoxyphenyl)ethyl)-N-methyl-, (E)  *Amides *Dioxoles *Phenethylamines Zanthoxylum. Yao Hsueh Hsueh Pao 1989;24(1):67
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine  120225-54-9   *Phenethylamines Adenosine/*analogs & derivatives.
Pharma Action Antihypertensive Agents ; Adenosine A2 Receptor Agonists 		J Pharmacol Exp Ther 1989;251(1):47
2-phenethylamino-5'-N-ethylcarboxamidoadenosine  120225-53-8 beta-D-Ribofuranuronamide, 1-(6-amino-2-((2-phenylethyl)amino)-9H-purin-9-yl)-1-deoxy-N-ethyl  *Phenethylamines Adenosine/*analogs & derivatives. J Pharmacol Exp Ther 1989;251(1):47
FLA 365  67759-58-4   *Phenethylamines. Naunyn Schmiedebergs Arch Pharmacol 1989;339(6):684
ractopamine  97825-25-7   *Phenethylamines Growth Substances.
Pharma Action Adrenergic beta-Agonists 		J Anim Sci 1989;67(6):1455
fantofarone  114432-13-2 Benzeneethanamine, 3,4-dimethoxy-N-methyl-N-(3-(4-((2-(1-methylethyl)-1-indolizinyl)sulfonyl)phenoxy)propyl)  *Indolizines *Phenethylamines Sphingomyelin Phosphodiesterase/antagonists & inhibitors.
Pharma Action Calcium Channel Blockers ; Enzyme Inhibitors ; Vasodilator Agents 		Naunyn Schmiedebergs Arch Pharmacol 1989;339(1-2):31
2,4,5-trimethoxyphenethylamine  15394-83-9   *Phenethylamines. Int J Rad Appl Instrum (B) 1989;16(1):91
pentafluorobenzoyl-N-phenylethylamine  38842-14-7   *Benzoates *Phenethylamines. Biomed Environ Mass Spectrom 1988;16(1-12):327
N,N',N''-tris-4-(3-iodo-4-methoxyphenyl)butyl-1,3,5-benzenetriethanamine  0   *Phenethylamines. Arch Oharm (Weinheim) 1988;321(11):813
1-(2,6-dimethylphenoxy)-2-(3,4-dimethoxyphenylethylamino)propane  113346-50-2   *Phenethylamines. Chung Kuo Yao Li Hsueh Pao 1988;9(1):64
Q 2636  99291-29-9 Benzeneethanamine, 4-amino-3,5-dichloro-N-(1,1-dimethylethyl)-beta-(((1,2-dimethylpropyl)dimethylsilyl)oxy)  *Phenethylamines *Organosilicon Compounds. Eur J Pharmacol 1988;151(2):177
2-(4-aminophenyl)ethylamine  13472-00-9   *Phenethylamines. Carbohydr Res 1988;177:222
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