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Phenylbutyrates

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Definition:      
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
glycerol phenylbutyrate  0   *Phenylbutyrates Glycerol/*analogs & derivatives. Mol Genet Metab. 2011 Aug;103(4):323-9.
4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butyl 4-phenylbutyrate  0   *Phenylbutyrates Haloperidol/*analogs & derivatives Receptors, sigma/antagonists & inhibitors. Eur J Med Chem 2011 Jan;46(1):433-8
4-(3-benzyloxy-4-methoxy)phenyl-3-butenoic acid  0   *Phenylbutyrates. ChemMedChem 2010 Sep 3;5(9):1568-76
4-(4-(2-(phenyl-2-pyridinylamino)ethoxy)phenyl)butyric acid  0   *Phenylbutyrates *Aminopyridines. Mol Pharmacol 2010 Nov;78(5):804-10
4-hydroxy-4-(4-(2-azido-5-iodobenzyloxy)phenyl)butanoic acid  0   *Azides *Phenylbutyrates Iodine Radioisotopes. J Pharmacol Exp Ther 2010 Nov;335(2):458-64
4-hydroxy-4-(4-(2-iodobenzyloxy)phenyl)butanoic acid  0   *Phenylbutyrates Iodine Radioisotopes. J Pharmacol Exp Ther 2010 Nov;335(2):458-64
1-phenylethylammonium-2-phenylbutyrate  0   *Phenylbutyrates. Chirality. 2010 May 5;22(4):447-55
Methyl 3-(3',5'-dimethoxyphenyl)-2-(1-(4-methylpiperazin-1-ylcarbamoyl)-2-phenylvinyl)-2-butenoate  0   *Butadienes *Phenylbutyrates. Bioorg Med Chem 2010 Mar 1;18(5):1968-99
2-(4-(4-(2,3-dihydroxy-propoxy)phenyl)-2,5-dioxo-imidazolidin-1-yl)-N-(2-fluoro-4-iodo-phenyl)-3-phenylbutyramide  0   *Phenylbutyrates *Imidazolidines. Mol Cancer Ther 2010 Jan;9(1):134-44
4-((4-hydroxyphenyl)sulfanyl)but-3-en-2-one  0   *Phenylbutyrates *Sulfhydryl Compounds. J Med Chem. 2009 Aug 13;52(15):4973-6
OSU-HDAC42 compound  0   *Phenylbutyrates Histone Deacetylases. Cancer Research 2008 May 15;68(10):3999-4009
HDAC-42  0   *Phenylbutyrates. Clin Cancer Res 2006 Sep 1;12(17):5199-206
butyroyloxymethyl 4-phenylbutyrate  0   *Phenylbutyrates Histone Deacetylases/antagonists & inhibitors. Cancer Lett 2007 Aug 18;253(2):205-14
2-(2-oxoazocan-3-ylamino)-4-phenylbutyric acid  0   *Azepines *Phenylbutyrates. Eur J Mass Spectrum (Chichester, Eng) 2006;12(2):121-7
serialynic acid  0   *Hydroquinones *Phenylbutyrates. J Antibiot (Tokyo) 2007 Apr;60(4):285-8
3-(5-chloroindole-2-carbonyl)amino-2-hydroxy-4-phenylbutyric acid N-methyl-N-methoxyamide  0   *Indoles *Phenylbutyrates. Am J Physiol Endocrinol Metab 2005 Sep;289(3):E366-72
2-((carboxymethyl)sulfanyl)-4-oxo-4-(2,4,6-triethylphenyl)butanoic acid  0   *Phenylbutyrates *Thioglycolates. J Med Chem 2005 Aug 25;48(17):5600-3
2-((carboxymethyl)sulfanyl)-4-oxo-4-(2,5-diisopropylphenyl)butanoic acid  0   *Phenylbutyrates *Thioglycolates. J Med Chem 2005 Aug 25;48(17):5600-3
N-hydroxy-4-(3-methyl-2-phenylbutyrylamino)benzamide  0   *Hydroxamic Acids *Phenylbutyrates Histone Deacetylases/antagonists & inhibitors. J Med Chem 2005 Aug 25;48(17):5530-5
fenbufen ethanolamide  0   *Phenylbutyrates. Arch Pharm (Weinheim). 2004 Oct;337(10):546-8
4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propionylamino)phenyl)butyric acid  0   *Naphthalenes *Phenylbutyrates. J Clin Invest 2002 Apr;109(7):883-93
ethyl 3-phenylbutyrate  0   *Phenylbutyrates. Chemistry. 2003 May 9;9(9):1933-9
thellungianin G  0   *Phenylbutyrates. Zhongguo Zhong Yao Za Zhi 1999 Sep;24(9):551-2, 575
2-amino-4-(3'-hydroxyphenyl)-4-hydroxybutanoic acid  0   *Hydroxybutyrates *Phenylbutyrates. Bioorg Med Chem Lett 2002 Feb 11;12(3):361-3
4-(2-amino-3-hydroxyphenyl)--4-oxobutanoic acid O-diglucoside  0   *Glucosides *Phenylbutyrates. FEBS Lett 2001 Nov 30;509(1):6-10
(4-hydroxymethylphenyl)-2-methylthiomethyl-4-oxobutanoic acid  0   *Phenylbutyrates. Drug Metab Dispos 2001 Jun;29(6):806-12
2,4-diphenylbutanoic acid  0   *Phenylbutyrates. J Org Chem 2000 Aug 25;65(17):5371-81
JE 533  0   *Dipeptides *Phenylbutyrates. Proc Natl Acad Sci USA 1999 Jul 20;96(15):8675-80
JE 2147  0   *Dipeptides *Phenylbutyrates HIV Protease Inhibitors. Proc Natl Acad Sci USA 1999 Jul 20;96(15):8675-80
2-benzyl-4-(3,4-dichlorophenyl)-4-oxobutanoic acid  0   *Phenylbutyrates. Bioorg Med Chem 1998 Oct 20;8(20):2907-12
2-hydroxy-4-(3,4-dichlorophenyl)-4-oxobutanoic acid  0   *Phenylbutyrates. Bioorg Med Chem Lett 1998 Oct 20;8(20):2907-12
4-(2-cyano-5-(3-pyridylmethoxy)phenoxy)-4-(2-methylphenyl)butanoic acid  0   *Phenylbutyrates *Pyridines Receptors, Endothelin/antagonists & inhibitors. J Med Chem 1998 Jul 16;41(15):2732-44
3-methoxy-2-methyl-4-phenylbutyric acid  0   *Phenylbutyrates. Toxicon 1996 Jun;34(6):701-10
KE 758  0   *Phenylbutyrates. Drugs Exp Clin Res 1996;22(1):1-8
4-(4-((2-hydroxybenzoyl)amino)phenyl)butyric acid  0   *Phenylbutyrates. J Med Chem 1996 Jun 21;39(13):2571-8
bucloxic acid  32808-51-8   *Phenylbutyrates.
Pharma Action Neuromuscular Agents
4-(3-(3-(bis(4-isobutylphenyl)methylamino)benzoyl)-1H-indol-1-yl)butyric acid  0   *Indoles *Phenylbutyrates.
Pharma Action 5-alpha Reductase Inhibitors 		J Steroid Biochem Mol Biol 1995 Apr;52(4):357-63
4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-glucoside  156913-43-8   *Glucosides *Phenylbutyrates. FEBS Lett 1994 Jul 11;348(2):173-6
2-hydroxy-4-phenylbutyric acid  4263-93-8 Benzenebutanoic acid, alpha-hydroxy  *Phenylbutyrates. J Biotechnol 1992 Jul;24(3):315-27
4-phenylbutyric acid  1821-12-1   *Phenylbutyrates.
Pharma Action Antineoplastic Agents 		N Engl J Med 1992 Aug 20;327(8):569-70BUPHENYL; SODIUM PHENYLBUTYRATE
ER 001533  142808-46-6 3-Butenamide, 4-(4-(((cyanoamino)(methylamino)methylene)amino)phenyl)-N-(3-((2-(3,5-dimethoxyphenyl)ethyl)methylamino)propyl)-, ethanedioate (1:1)  *Guanidines *Phenylbutyrates. Circ Res 1992 May;70(5):1054-61
4-(3,3-dimethyl-1-triazeno)phenylbutyric acid  138559-70-3   *Phenylbutyrates *Triazenes. Arzneimittelforschung 1991 Nov;41(11):1168-72
2-hydroxy-2-phenylbutyramide  131802-71-6   *Phenylbutyrates. Arzneimittelforschung 1990;40(12):1289
2-aminomethyl-4-(4-chlorophenyl)-4-hydroxybutyric acid  129238-76-2   *Phenylbutyrates. Pol J Pharmacol Pharm 1989;41(1):77
SCH 33861  83602-05-5 1,4-Dithia-7-azaspiro(4.4)nonane-8-carboxylic acid, 7-(2-((1-carboxy-3-phenylpropyl)amino)-1-oxopropyl)-, (8S-(7(R*(R*)),8R*))  *Phenylbutyrates *Spiro Compounds. Am J Ophthalmol 1988;105(6):674
2-hydroxybenzalpyruvate  90293-62-2   *Phenylbutyrates. Indian J Biochem Biophys 1986;23(2):110
L 649923  91542-58-4   *Phenylbutyrates.
Pharma Action Leukotriene Antagonists 		J Med Chem 1986;29(9):1573
4-oxo-4-(3,4,5-trimethoxyphenyl)-2-butenoic acid  84386-11-8   *Phenylbutyrates. Arzneimittelforschung 1985;35(9):1412
methyl 2-(4-chlorophenyl)-3-methylbutyrate  104486-05-7   *Phenylbutyrates. Radioisotopes 1985;34(8):401
2-phenylbutyric acid  1009-67-2   *Phenylbutyrates. J Chromatogr 1983;277:61
metbufen  63472-04-8   *Phenylbutyrates. J Pharm Pharmacol 1983;35(9):526
3-phenylbutyric acid  4593-90-2   *Phenylbutyrates. J Bacteriol 1982;152(1):411
3-(2,3-dihydroxyphenyl)butyric acid  83801-01-8 Benzenepropanoic acid, 2,3-dihydroxy-beta-methyl  *Phenylbutyrates. J Bacteriol 1982;152(1):411
3-amino-2-hydroxy-4-phenylbutanoic acid  62084-21-3   *Phenylbutyrates.
Pharma Action Antimalarials ; Protease Inhibitors 		Life Sci 1982;30(20):1739
beta-benzalbutyramide  7236-47-7   *Phenylbutyrates. Farmaco (Prat) 1981;36(12):532
3-methyl-4-phenyl-3-butenoic acid diethylamide  58458-55-2 N,N-diethyl-3-methyl-4-phenyl-3-butenamide  *Phenylbutyrates. Eur J Drug Metab Pharmacokinet 1979;4(4):231
indobufen  36690-96-7 4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl) alpha- ethylbenzeneacetic acid  *Phenylbutyrates *Isoindoles.
Pharma Action Platelet Aggregation Inhibitors ; Cyclooxygenase Inhibitors 		Arzneim Forsch 29(1):104;1979; Eur J Clin Pharmacol 15(5):323;1979; Haematologica 62(2):127;1977; Pharmacol Res Commun 11(3):279;1979; Thromb Res 1980;17(3-4):303
gamma-hydroxy-gamma-ethyl-gamma-phenylbutyramide  67880-30-2 Benzenebutanamide, gamma-ethyl-gamma-hydroxy  *Phenylbutyrates. Epilepsia 20(2):135;1979
ethyl methylphenylglycidate  77-83-8   *Phenylbutyrates Flavoring Agents. Food Cosmet Toxicol 16(4):331;1978
4-(2-methyl-3-(4-chlorobenzoyl)phenyl)butanoic acid  41651-99-4 Benzenebutanoic acid, 3-(4-chlorobenzoyl)-2-methyl  *Phenylbutyrates. Xenobiot 8(7):429;1978
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