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Phenylpropanolamine

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Definition: A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant.     
Pharmacological Action Adrenergic alpha-Agonists; Appetite Depressants; Nasal Decongestants; Sympathomimetics
Examples p-Hydroxynorephedrine; Metaraminol
Other names Norephedrine; Hydrochloride, Phenylpropanolamine; Propagest; Prolamine; Phenylpropanolamine Hydrochloride; Dexatrim
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
acetaminophen, chlorpheniramine, dextromethorphan, phenylpropanolamine drug combination  0   *Acetaminophen *Chlorpheniramine *Dextromethorphan *Phenylpropanolamine Drug Combinations. Vet Hum Toxicol 2002 Jun;44(3):169-71
lipokinetix  0   *Benzofurans *Caffeine *Diiodothyronines *Phenylpropanolamine *Yohimbine. Ann Intern Med 2002 Apr 16;136(8):590-5
Night Nurse  0   *Acetaminophen *Dextromethorphan *Phenylpropanolamine *Promethazine Drug Combinations. Eye 2001 Apr;15(Pt 2):248-9
N-fluoroisopropylnorephedrine  176587-88-5   Phenylpropanolamine/*analogs & derivatives. Nucl Med Biol 1996 Feb;23(2):155-7
tolterodine  124937-51-5   *Benzhydryl Compounds *Cresols *Phenylpropanolamine.
Pharma Action Muscarinic Antagonists
Neurourol Urodyn 1995;14(6):647-55DETROL; DETROL LA; TOLTERODINE; TOLTERODINE TARTRATE
rhinopront syrup  0   *Phenylpropanolamine *Pyridines Drug Combinations. Clin Trials Metaanal 1994 Oct;29(2-3):113-24
chlorpheniramine, phenylpropanolamine drug combination  0   *Chlorpheniramine *Phenylpropanolamine Drug Combinations.
Pharma Action Sympathomimetics
Am Pharm 1993 Aug;NS33(8):42COLD CAPSULE IV; DRIZE; TRIAMINIC-12; PHENYLPROPANOLAMINE HYDROCHLORIDE W/ CHLORPHENIRAMINE MALEATE; CONTAC; CHLOROHENIRAMINE MALEATE AND PHENYLPROPANOLAMINE HYDROCHLORIDE; CONTAC 12 HOUR; DEMAZIN; COLD CAPSULE V; CHLORPHENIRAMINE MALEATE AND PHENYLPROPANOLAMINE HYDROCHLORIDE
Falepsin  56343-96-5   *Phenobarbital *Phenylpropanolamine Drug Combinations. Kardiologiia 1987;27(5):48
D 16427  106697-24-9   Phenylpropanolamine/*analogs & derivatives. Arch Pharm (Weinheim) 1986;319(12):1113
Triaminicin  138331-08-5   *Aspirin *Chlorpheniramine *Phenylpropanolamine Drug Combinations. JAMA 1985;253(18):2646
2-methyl-3,3-diphenyl-3-propanolamine  33860-73-0   Phenylpropanolamine/*analogs & derivatives. Pharmacol Biochem Behav 1984;20(2):209
pholcolix  90326-84-4 Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-17-methyl-3-(2-(4-morpholinyl)ethoxy)-, (5alpha,6alpha)-, mixt. with (R*,S*)-(+-)-alpha-(1-aminoethyl)benzenemethanol and N-(4-hydroxyphenyl)acetamide  *Acetaminophen *Phenylpropanolamine Codeine/*analogs & derivatives Drug Combinations. Curr Med Res Opin 1983;8(8):594
antiadipositum X 112  92526-18-6 Antiadipositum X 112  *Nikethamide *Phenylpropanolamine *Salicylic Acids Drug Combinations. JAMA 1983;250(16):2112
rhinasal  89212-58-8 Acetamide, N-(4-hydroxyphenyl)-, mixt. with (R-(R*,S*))-alpha-(1-aminoethyl)benzenemethanol hydrochloride and Trasinanium methanesulfonate  *Acetaminophen *Phenylpropanolamine Drug Combinations. Presse Med 1983;12(27):1725
chlorpheniramine, phenylephrine, phenylpropanolamine drug combination  0   *Chlorpheniramine *Phenylephrine *Phenylpropanolamine Multi-Ingredient Cold, Flu, and Allergy Medications. J Laryngol Otol 1983;97(3):CORSYM
chlorpheniramine, phenylephrine, phenylpropanolamine, phenyltoloxamine drug combination  0   *Benzhydryl Compounds *Chlorpheniramine *Phenylephrine *Phenylpropanolamine Drug Combinations Multi-Ingredient Cold, Flu, and Allergy Medications. J Pediatr 1982;101(1):132
3-phenyl-2-amino-1,3-propanediol decanoylamide  35922-20-4   Phenylpropanolamine/*analogs & derivatives. Brain Res 102(2):267;1976
acetaminophen, phenylpropanolamine, phenyltoloxamine drug combination  0   *Acetaminophen *Benzhydryl Compounds *Phenylpropanolamine Drug Combinations. Med J Aust 1(24):763;1975
Ornade  50808-49-6   *Quaternary Ammonium Compounds *Chlorpheniramine *Phenylpropanolamine Drug Combinations. Clin Toxicol 7(6):573;1974ORNADE
4-chloronorpseudoephedrine  52373-27-0 Benzenemethanol, alpha-(1-aminoethyl)-4-chloro-, hydrochloride, (S-(R*,R*))  Phenylpropanolamine/*analogs & derivatives. J Med Chem 17(4):416;1974
4-chloronorephedrine  23933-83-7   Phenylpropanolamine/*analogs & derivatives. J Med Chem 17(4):416;1974
HSP 525 A  39471-18-6 beta-aminobenzenepropanol, mixt. with 2-(2-(1-(4-chlorophenyl)-1-phenylethoxy)ethyl)-1-methylpyrrolidine  *Clemastine *Phenylpropanolamine Drug Combinations. Int J Clin Pharmacol Ther Toxicol 8(1):58;1973TAVIST-D
N-diethylnorpseudoephedrine  37025-60-8   Phenylpropanolamine/*analogs & derivatives. J Pharm Pharmacol 25(2):119;1973
N-ethylnorpseudoephedrine  18259-40-0   Phenylpropanolamine/*analogs & derivatives. J Pharm Pharmacol 25(2):119;1973
norpseudoephedrine  36393-56-3   *Phenylpropanolamine.
Pharma Action Appetite Depressants
East Afr Med J 22(6):330;1975; J Pharm Pharmacol 25(2):119;1973
norephendrinetheophylline  14535-83-2   Phenylpropanolamine/*analogs & derivatives Theophylline/*analogs & derivatives Hypotension/drug therapy. Arzneim Forsch 22(4):693;1972
Eskornade Spansules  77306-14-0 Benzenepropanaminium, gamma-(aminocarbonyl)-N-methyl-N,N-bis(1-methylethyl)-gamma-phenyl-, iodide, mixt. with (R*,S*)-(+-)-alpha-(1-aminoethyl)benzenemethanol hydrochloride and 4-(diphenylmethoxy)-1-methylpiperidine hydrochloride  *Quaternary Ammonium Compounds *Phenylpropanolamine *Piperidines Drug Combinations. S Afr Med J 46(19):579;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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