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Phenylurea Compounds

More information in Books or onNLM PubMed
Definition:   DF: PHENYLUREA CPDS   
Examples Carbanilides; Celiprolol; Diflubenzuron; Diuron; Linuron 		Other names Phenylcarbamides; Compounds, Phenylurea
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PQ 401  0   *Aminoquinolines *Phenylurea Compounds. Mol Cancer Ther. 2006 Apr;5(4):1079-86.
1-(4-(2-ethoxy-4-methyl-1H-pyrrol-1-yl)-3-hydroxy-2,2-dimethylchroman-6-yl)-3-phenylurea  0   *Phenylurea Compounds Cromakalim/*analogs & derivatives. Int J Oncol. 2011 Dec;39(6):1609-17.
BPR1K653  0   *Phenylurea Compounds *Bicyclo Compounds, Heterocyclic. PLoS One. 2011;6(8):e23485.
3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea  0   *Phenylurea Compounds *Pyrimidines Receptor, Fibroblast Growth Factor, Type 1/antagonists & inhibitors. J Med Chem. 2011 Oct 27;54(20):7066-83.
SB 656933  0   *Phenylurea Compounds *Sulfonamides Receptors, Interleukin-8B/antagonists & inhibitors. Br J Clin Pharmacol. 2011 Aug;72(2):282-93.
N-(2-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)ethyl)glycyrrhetinamide  0   *Phenylurea Compounds Glycyrrhetinic Acid/*analogs & derivatives. J Med Chem. 2011 Oct 13;54(19):6501-13.
1-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno(2,3-d)pyrimidin-6-yl)phenyl)-3-methoxyurea  0   *Phenylurea Compounds *Pyrimidinones Receptors, LHRH/antagonists & inhibitors. J Med Chem 2011 Jul 28;54(14):4998-5012
1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea  0   *Phenylurea Compounds *Piperidines Epoxide Hydrolases/antagonists & inhibitors. J Cardiovasc Pharmacol 2011 Mar;57(3):273-81
1-(1-(2-amino-pyridin-4-ylmethyl)-1H-indol-4-yl)-3-(5-bromo-2-methoxyphenyl)urea  0   *Indoles *Phenylurea Compounds Receptor, EphB4/antagonists & inhibitors. Biomed Chromatogr 2011 Jul;25(7):794-800
3,4-dichlorophenylurea  0   *Phenylurea Compounds. J Hazard Mater. 2011 Jun 15;190(1-3):930-7
XZH-5 compound  0   *Phenylurea Compounds Histidine/*analogs & derivatives. Apoptosis 2011 May;16(5):502-10
4-(4-(((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)amino)-3-fluorophenoxy)-n-methylpyridine-2-carboxamide  0   *Phenylurea Compounds *Pyridines. Int J Cancer 2011 Jul 1;129(1):245-55
1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo(3,4-b)pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea  0   *Phenylurea Compounds *Bicyclo Compounds, Heterocyclic. J Med Chem 2011 Mar 24;54(6):1667-81
(5-hydroxycarbamoyl-5-(3-(1-hydroxycarbamoyl-3-methyl-butyl)ureido)pentyl)carbamic acid benzyl ester  0   *Phenylurea Compounds Lysine/*analogs & derivatives. Bioorg Med Chem. 2011 Jan 15;19(2):900-6
1-(1-nicotinoylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea  0   Niacinamide/*analogs & derivatives Phenylurea Compounds Epoxide Hydrolases/antagonists & inhibitors. Eur J Pharmacol 2011 Mar 1;654(1):68-74
DP 802  0   *Phenylurea Compounds *Pyrazoles p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors. Bioorg Med Chem Lett 2010 Oct 1;20(19):5793-8
H128 compound  0   *Biphenyl Compounds *Phenylurea Compounds Diacylglycerol O-Acyltransferase/antagonists & inhibitors. Acta Pharmacol Sin 2010 Nov;31(11):1470-7
1-(2-fluoro-4-((5-methyl-5H-pyrrolo(3,2-d)pyrimidin-4-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea  0   *Phenylurea Compounds *Bicyclo Compounds, Heterocyclic Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors. Bioorg Med Chem 2010 Oct 15;18(20):7260-73
1-(2-chloro-4-((5-methyl-5H-pyrrolo(3,2-d)pyrimidin-4-yl)oxy)phenyl)-3-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)urea  0   *Phenylurea Compounds *Bicyclo Compounds, Heterocyclic Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors Receptor, Fibroblast Growth Factor, Type 1/antagonists & inhibitors. Bioorg Med Chem 2010 Oct 15;18(20):7150-63
GDP 366  0   *Phenylurea Compounds *Bicyclo Compounds, Heterocyclic. Cancer Biol Ther 2010 Apr;9(8):640-50
tivozanib  0   *Phenylurea Compounds *Quinolines Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors. IDrugs 2010 Sep;13(9):636-45
1-(2-(2-(6-aminohexylamino)ethoxy)-5-bromophenyl)-3-(2-chlorophenyl)urea  0   *Phenylurea Compounds Alzheimer Disease/drug therapy. Bioorg Med Chem. 2010 Aug 1;18(15):5610-5
1-(2-hydroxy-1-phenylethyl)-3-(4-(pyridin-4-yl)phenyl)urea  0   *Phenylurea Compounds *Pyridines rho-Associated Kinases/antagonists & inhibitors. J Pharmacol Exp Ther 2010 Sep 1;334(3):955-63
ABT 116  0   *Indazoles *Phenylurea Compounds TRPV Cation Channels. Bioorg Med Chem Lett 2010 Jun 1;20(11):3291-4
PKI 402  0   *Phenylurea Compounds *Pyrimidines Phosphatidylinositol 3-Kinases/antagonists & inhibitors. Mol Cancer Ther 2010 Apr;9(4):976-84
1-(2-bromophenyl)-3-(7-cyano-3H-benzotriazol-4-yl)urea  0   *Triazoles *Phenylurea Compounds Receptors, Interleukin-8B. Br J Pharmacol 2009 Sep;158(1):328-38
N-(2-(dimethylamino)ethyl)-N-methyl-4-(((4-(4-morpholin-4-yl-7-(2,2,2-trifluoroethyl)-7H-pyrrolo(2,3-d)pyrimidin-2-yl)phenyl)carbamoyl)amino)benzamide  0   *Benzamides *Phenylurea Compounds Phosphatidylinositol 3-Kinases/antagonists & inhibitors. J Med Chem 2010 Apr 22;53(8):3169-82
N6-(((4-(4-(acetylamino)benzyl)phenyl)amino)carbonyl)lysine  0   *Phenylurea Compounds Lysine/*analogs & derivatives. Chem Res Toxicol 2009 Dec;22(12):1975-83
N6-(((4-(4-aminobenzyl)phenyl)amino)carbonyl)lysine  0   *Phenylurea Compounds Lysine/*analogs & derivatives. Chem Res Toxicol 2009 Dec;22(12):1975-83
WYE 125132  0   *Phenylurea Compounds *Pyrazoles. Cancer Res 2010 Jan 15;70(2):621-31
nelotanserin  0   *Pyrazoles *Phenylurea Compounds. J Pharmacol Exp Ther 2010 Jan;332(1):281-90
1-(4-(6-amino-5-(methoxyiminomethyl)pyrimidin-4-yloxy)-2-chlorophenyl)-3-ethylurea  0   *Oximes *Phenylurea Compounds Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors. Angiogenesis 2009;12(3):287-96
AC220 compound  0   *Benzothiazoles *Phenylurea Compounds. Blood 2009 Oct 1;114(14):2984-92
(IR,2R)-2-(4'-(3-phenyl-ureido)-biphenyl-4-carbonyl)cyclopentanecarboxylic acid  0   *Biphenyl Compounds *Phenylurea Compounds Diacylglycerol O-Acyltransferase/antagonists & inhibitors. J Pharmacol Exp Ther. 2009 Aug;330(2):526-31
SB 408124  0   *Phenylurea Compounds. Biol Psychiatry 2009 May 15;65(10):857-62
1-(3,5-bis-trifluoromethylphenyl)-3-(2,4-dibromo-6-(1H-tetrazol-5-yl)phenyl)urea  0   *Phenylurea Compounds *Tetrazoles. Cardiovasc Res 2009 Mar 1;81(4):686-94
N,N'-bis(2-(phenylthio)phenyl)urea  0   *Phenylurea Compounds *Sulfides. Pharm Dev Technol 2009;14(1):27-37
1-(3-iodophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)urea  0   *Benzodiazepines *Phenylurea Compounds Receptor, Cholecystokinin A/antagonists & inhibitors Receptor, Cholecystokinin B/antagonists & inhibitors. J Med Chem 2009 Apr 9;52(7):2138-47
CEP 14083  0   *Carbazoles *Phenylurea Compounds. Blood 2006 Feb 15;107(4):1617-23
1-(5-(2-(3,5-dimethoxyphenyl)vinyl)-2-methoxyphenyl)-3-(2-morpholin-4-ylethyl)urea  0   *Morpholines *Phenylurea Compounds. Invest New Drugs 2009 Feb;27(1):41-52
N-(4-methyl-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)phenyl)-N'-phenylurea  0   *Phenylurea Compounds *Pyrimidines. J Cardiovasc Pharmacol 2008 Nov;52(5):403-12
SNS 314  0   *Phenylurea Compounds *Thiazoles. Bioorg Med Chem Lett 2008 Sep 1;18(17):4880-4
4-(3-chloro-4-(N'-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxamide  0   *Phenylurea Compounds *Quinolines. Int J Cancer 2008 Feb 1;122(3):664-71
AR 246686  0   *Phenylurea Compounds Receptor, Serotonin, 5-HT2A/antagonists & inhibitors. Eur J Pharmacol 2008 May 31;586(1-3):234-43
1-(4-(3-amino-7-methoxybenzo(d)isoxazol-4-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea  0   *Isoxazoles *Phenylurea Compounds Receptor Protein-Tyrosine Kinases/antagonists & inhibitors. J Med Chem 2008 Mar 13;51(5):1231-41
AVN 944  0   *Carbamates *Phenylurea Compounds IMP Dehydrogenase/antagonists & inhibitors. Leuk Res 2008 Jan;32(1):131-41
1-(4-chlorophenyl)-3-(3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl)urea  0   *Phenylurea Compounds *Pyridines Receptor, Cannabinoid, CB1/antagonists & inhibitors. Br J Pharmacol 2007 Nov;152(5):805-14
JNJ 10397049  0   *Dioxanes *Phenylurea Compounds. Am J Physiol Endocrinol Metab 2007 Oct;293(4):E977-85
1-(5-chloro-2-hydroxyphenyl)-3-(2-chloro-5-trifluoromethylphenyl)urea  0   *Phenylurea Compounds. J Pharmacol Exp Ther 2007 Oct;323(1):294-307
N-(phenylcarboxamido)cytosine  0   *Phenylurea Compounds Cytosine/*analogs & derivatives. Nucleic Acids Symp Ser (Oxf) 2006;(50):201-2
N-(phenylcarboxamido)adenosine  0   *Phenylurea Compounds Adenosine/*analogs & derivatives. Nucleic Acids Symp Ser (Oxf) 2006;(50):201-2
S 30621  0   *Hydroxamic Acids *Phenylurea Compounds Arachidonate 5-Lipoxygenase/antagonists & inhibitors. Carcinogenesis 2007 May;28(5):957-61
S 29606  0   *Hydroxamic Acids *Phenylurea Compounds Arachidonate 5-Lipoxygenase/antagonists & inhibitors. Carcinogenesis 2007 May;28(5):957-61
1-(2-fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)urea  0   *Benzodiazepinones *Phenylurea Compounds. J Med Chem 2007 Apr 5;50(7):1685-92
1,1'-(1,2-phenylene)bis(3-phenylurea)  0   *Phenylurea Compounds. Chem Commun (Camb) 2005 Oct 7;(37):4696-8
N(1)-phenyl-N(2)-(2-pyridinylmethyl)diazenedicarboxamide  0   *Aza Compounds *Phenylurea Compounds. Cell Biol Toxicol 2006 Jan;22(1):61-71
VX 702  0   *Phenylurea Compounds. Curr Opin Investig Drugs 2006 Nov;7(11):1020-5
N-(4-((6,7-dimethoxy-4-quinolyl)oxy)-2-methoxyphenyl)-N'-(1-(1,3-thiazole-2-yl)ethyl)urea  0   *Phenylurea Compounds *Thiazoles. Mol Cancer Ther 2006 Nov;5(11):2634-43
4-((N'-2-methylphenyl)ureido)phenylalanyl-leucyl-alpha-aspartyl-valyl-prolyl-alanyl-alanyl-lysine  0   *Oligopeptides *Phenylurea Compounds. Blood 2007 Jan 1;109(1):176-84
4-(1-(3-chloro-4-(N-(2-methylphenyl)ureido)phenylacetyl)-4-fluoropyrrolidine-2-yl)methoxybenzoic acid  0   *Phenylurea Compounds *Pyrrolidines Integrin alpha4beta1/antagonists & inhibitors. J Pharmacol Exp Ther 2007 Jan;320(1):124-32
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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