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Phosphinic Acids

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Definition: Inorganic or organic derivatives of phosphinic acid, H2PO(OH). They include phosphinates and phosphinic acid esters.  do not confuse with PHOSPHONIC ACIDS    Other names Hypophosphorous Acids; Acids, Phosphinic; Acids, Hypophosphorous; Acid, Phosphinic; Phosphinic Acid
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
triazacyclononane-phosphinic acid  0   *Aza Compounds *Phosphinic Acids Chelating Agents. Chemistry. 2011 Dec 23;17(52):14718-22
GS-9256  0   *Peptides, Cyclic *Phosphinic Acids. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1394-6.
pirafen  0   *Phosphinic Acids *Pyrimidines Plant Growth Regulators. Dokl Biochem Biophys. 2011 Nov-Dec;441():283-6
2-((3-(hydroxyl(2-phenyl-1-(((benzyloxy)carbonyl)amino)ethyl)phosphinyl)-2-((3-phenylisoxazol-5-yl)methyl)-1-oxo-propyl)amino)-3-(4-hydroxy-phenyl)propanoic acid  0   *Oligopeptides *Phosphinic Acids Angiotensin-Converting Enzyme Inhibitors. Biochem J 2011 May 15;436(1):53-9
methyl 2-(aminocarbonyl)-5-chloro-1H-indol-3-yl-(phenyl)phosphinate  0   *Indoles *Phosphinic Acids HIV Reverse Transcriptase/antagonists & inhibitors. J Med Chem 2011 Jan 13;54(1):392-5
LSP1 2111  0   *Aminobutyric Acids *Phosphinic Acids Receptors, Metabotropic Glutamate/agonists. FASEB J 2009 Oct;23(10):3619-28
bis(2-(3-carboxyphenoxy)carbonylethyl)phosphinic acid  0   *Hydroxybenzoic Acids *Phosphinic Acids Cross-Linking Reagents. Bioconjug Chem. 2010 Aug 18;21(8):1494-507
N-methyl-aminomethyl-P-hydroxymethylphosphinic acid  0   *Phosphinic Acids Urease/antagonists & inhibitors. J Med Chem 2010 Aug 12;53(15):5597-606
IDX989  0   *Indoles *Phosphinic Acids. J Clin Pharmacol. 2009 Dec;49(12):1408-16
phenyl-2,4,6-trimethylbenzoylphosphinate  0   *Phosphinic Acids. Biomaterials 2009 Dec;30(35):6702-7
lesogaberan  0   *Phosphinic Acids *Propylamines Receptors, GABA-A/agonists. IDrugs 2009 Sep;12(9):576-84
IDX 899  0   *Indoles *Phosphinic Acids. Curr Opin Drug Discov Devel 2008 Jul;11(4):458-70
methylphosphinic acid  0   *Phosphinic Acids. Int J Toxicol 2007 Nov-Dec;26(6):503-12
RXP 409  0   *Phosphinic Acids Tryptophan/*analogs & derivatives Matrix Metalloproteinases/antagonists & inhibitors. Hepatalogy 2008 Jan;47(1):177-85
desmethylphosphinothricin  0   *Aminobutyric Acids *Phosphinic Acids. J Med Chem 2007 Sep 20;50(19):4656-64
Cyanex 302  0   *Organothiophosphorus Compounds *Phosphinic Acids. J Hazard Mater 2007 Jun 25;145(1-2):221-6
Cyanex 272  0   *Phosphinic Acids. J Hazard Mater 2007 Jun 25;145(1-2):221-6
3-amino-2-hydroxypropylcyclohexylmethylphosphinic acid  0   *Phosphinic Acids Receptors, GABA-B/antagonists & inhibitors. Br J Pharmacol 2006 Nov;149(5):581-90
1,4,7,10-tetraazacyclododecane-1,4,7-triacetic-10-methyl(4-aminobenzylphosphinic) acid  0   *Aza Compounds *Phosphinic Acids. Inorg Chem. 2006 Apr 3;45(7):3097-102
2,4-dinitrophenyl-homophenylalanyl-psi(PO2HCH2)-phenylalanine  0   *Dipeptides *Phosphinic Acids. Electrophoresis 2006 Nov;27(21):4312-20
benzyloxycarbonyl-homophenylalanyl-psi(PO2HCH2)-phenylalanine methyl ester  0   *Dipeptides *Phosphinic Acids. Electrophoresis 2006 Nov;27(21):4312-20
AR60 compound  0   *Phosphinic Acids Aspartic Acid/*analogs & derivatives Neprilysin/antagonists & inhibitors. Angew Chem Int Ed Engl 2005 Jun 27;44(26):4058-61
AR58 compound  0   *Phosphinic Acids Aspartic Acid/*analogs & derivatives Neprilysin/antagonists & inhibitors. Angew Chem Int Ed Engl 2005 Jun 27;44(26):4058-61
N-((4-deoxy-4-amino-10-methyl)pteroyl)glutamate-gamma-(psiP(O)(OH))-glutarate  0   *Phosphinic Acids Aminopterin/*analogs & derivatives. J Med Chem 2006 Jan 26;49(2):770-88
melaphene  0   *Phosphinic Acids *Triazines. Dokl Biochem Biophys 2005 Mar-Apr;401:136-8
2-(hydroxypentafluorophenylmethylphosphinoylmethyl)pentanedioic acid  0   *Glutarates *Phosphinic Acids Glutamate Carboxypeptidase II/antagonists & inhibitors. J Med Chem 2005 Apr 7;48(7):2319-24
bis(2-(4-phosphonooxyphenoxy)carbonylethyl)phosphinic acid  0   *Phosphinic Acids *Phosphoric Acid Esters. J Med Chem 2004 Nov 18;47(24):5847-59
N,N'-bis(dihexylphosphinoylmethyl)-1,4-diaminocyclohexane  0   *Cyclohexylamines *Phosphinic Acids. Med Sci Monit 2004 Aug;10(8):BR294-9
sodium di-(n-octyl)phosphinate  0   *Phosphinic Acids. Water Res 2004 Apr;38(7):1745-52
7-amino-2-(((2-methyl-1-(3-phenylpropanoylamino)propyl)hydroxyphosphinoyl)methyl)heptanoic acid  0   *Amino Acids *Phosphinic Acids Carboxypeptidase B/antagonists & inhibitors. J Pharmacol Exp Ther 2004 May;309(2):607-15
(1-benzyloxycarbonylamino-2-phenylethyl)-(2-(1-carbamoyl-2-(1H-indol-3-yl)ethylcarbamoyl)-3-(2-methoxyphenylsulfanyl)propyl)phosphinic acid  0   *Indoles *Phosphinic Acids. J Med Chem 2004 Jan 15;47(2):325-36
phenylphosphinic acid  1779-48-2   *Phosphinic Acids. Drug Chem Toxicol. 2003 May;26(2):125-33
RXPA380  0   *Oligopeptides *Phosphinic Acids. Circ Res 2003 Jul 25;93(2):148-54
4,4'-phosphinicobis(butane-1,3-dicarboxylic acid)  0   *Glutarates *Phosphinic Acids. J Med Chem 2002 Sep 12;45(19):4140-52
1alpha-hydroxy A-ring phosphine oxide  0   *Phosphinic Acids. J Org Chem 2002 Mar 8;67(5):1580-7
p-amidinophenylmethylphosphinic acid  0   Phosphinic Acids. Bioorg Med Chem 2002 Jan;10(1):41-6
2-decarboxy-2-(P-methylphosphinico)-16-phenoxytetranorprostaglandin F(2alpha)  0   *Phosphinic Acids Dinoprost/*analogs & derivatives. J Med Chem 2001 Nov 22;44(24):4157-69
bis((bis(carboxymethyl)amino)methyl)phosphinate  0   *Phosphinic Acids Contrast Media. Inorg Chem 2001 Jul 16;40(15):3734-8
CGP 36216  0   *Phosphinic Acids. Eur J Pharmacol 2001 Mar 16;415(2-3):191-5
CGP 67780  0   *Phosphinic Acids *Benzoic Acids. Nucl Med Biol 2000 Aug;27(6):565-9
1-amino-3-(methyl-(5'-deoxy-5'-adenosyl)thio)propylphosphinic acid  0   *Phosphinic Acids Methionine/*analogs & derivatives. Bioorg Khim 2000 Sep;26(9):718-20
1-amino-3-(methylthio)propylphosphinic acid  0   *Phosphinic Acids Methionine/*analogs & derivatives Stereoisomerism. Bioorg Khim 2000 Sep;26(9):718-20
3,3-dichloro-2-dihydroxyphosphinoylmethyl-2-propenoate  0   *Acrylates *Phosphinic Acids Phosphoenolpyruvate Carboxylase/antagonists & inhibitors. Plant Cell Physiol 2000 Jan;41(1):10-5
bis(glutar-2-ylmethyl)phosphinic acid  0   *Glutarates *Phosphinic Acids Receptors, Metabotropic Glutamate/antagonists & inhibitors. J Med Chem 2000 Mar 9;43(5):769-71
CGP 47332A  0   *Phosphinic Acids Receptors, GABA-B/antagonists & inhibitors. Eur J Pharmacol 1999 Oct 27;383(2):137-41
3-aminopropyl-(1,1,-difluoro-n-butyl)phosphinic acid  0   *Phosphinic Acids Receptors, GABA-B/antagonists & inhibitors. Eur J Pharmacol 1999 Jun 25;374(3):351-4
3-aminopropyl-P-(alpha-hydroxybenzyl)phosphinic acid  0   *Phosphinic Acids Receptors, GABA-B/antagonists & inhibitors. Eur J Pharmacol 1999 Jun 25;374(3):351-4
bis(2,2-dimethylaziridinyl)phosphinic amide  0   *Aziridines *Phosphinic Acids. Acta Crystallogr C 1999 Jul 15;55( Pt 7):1173-5
N-(4,4-diphenyl-3-butenyl)piperidinyl-3-phosphinic acid  0   *Phosphinic Acids *Piperidines gamma-Aminobutyric Acid. Bioorg Med Chem Lett 1999 Mar 22;9(6):811-4
piperidinyl-3-phosphinic acid  0   *Phosphinic Acids *Piperidines gamma-Aminobutyric Acid. Bioorg Med Chem Lett 1999 Mar 22;9(6):811-4
2-dihydroxyphosphinoyl-5-(guanin-9'-ylmethyl)tetrahydrofuran  0   *Phosphinic Acids Guanine/*analogs & derivatives. Antimicrob Agents Chemother 1999 Mar;43(3):557-67
bis(phenoxycarbonylethyl)phosphinic acid  0   *Phosphinic Acids. Hemoglobin 1999 Feb;23(1):1-20
RXP 407  0   *Oligopeptides *Phosphinic Acids. Proc Natl Acad Sci U S A 1999 Apr 13;96(8):4330-5
CGP 44532  0   *Phosphinic Acids gamma-Aminobutyric Acid/*analogs & derivatives Receptors, GABA-B/agonists. Life Sci 1998;62(17-18):1525-30
bis(2-(4-carboxyphenoxy)carbonylethyl) phosphinic acid  0   *Hydroxybenzoic Acids *Phosphinic Acids. Artif Cells Blood Substit Immobil Biotechnol 1997 Nov;25(6):511-20
SQ 32709  0   *Phosphinic Acids *Phosphonic Acids. Arch Biochem Biophys 1997 Sep 1;345(1):1-9
CGP 61334  0   *Phosphinic Acids *Benzoic Acids Receptors, GABA-B/antagonists & inhibitors. Eur J Pharmacol 1997 Feb 5;320(1):9-13
(3-(1-((3-(cyclohexylmethyl)hydroxyphosphinyl)-2-hydroxypropyl)amino)ethyl)benzoic acid  153994-81-1   *Phosphinic Acids *Benzoic Acids Receptors, GABA-B/antagonists & inhibitors. Eur J Pharmacol 1997 Feb 5;320(1):9-13
CGP 56999A  0   *Phosphinic Acids Stereoisomerism. Br J Pharmacol 1996 Jul;118(5):1153-60
(1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid  0   *Phosphinic Acids *Pyridines. Mol Pharmacol 1996 Oct;50(4):1024-30
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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