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Phosphodiesterase Inhibitors

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Definition: Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.  DF: PHOSPHODIESTERASE INHIB   
Examples Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Phosphodiesterase 5 Inhibitors 		Other names Phosphoric Diester Hydrolase Inhibitors; Phosphodiesterase Antagonists; Antiphosphodiesterases
Substances having this pharmacologic action: cilostamide; prostaglandin Bx; 2-nitro-4-carboxyphenyl-N,N-diphenylcarbamate; edelfosine; dodecylphosphocholine; sulmazole; doxofylline; lipomodulin; ibudilast; piroximone; pimobendan; vesnarinone; imazodan; 4,5-dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2H)-pyridazinone; wortmannin; doxantrazole; simendan; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Theophylline; 1-Methyl-3-isobutylxanthine; Trapidil; Papaverine; Pentoxifylline; Dipyridamole; Dyphylline; Caffeine; Etazolate; Aminophylline; zaprinast; phthalazinol; vinpocetine; E 4021; torborinone; zardaverine; 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one; EMD 53998; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione; 2-(4-amylcinnamoyl)amino-4-chlorobenzoic acid; siguazodan; UD CG 212 Cl; 1,5-dihydro-7-(1-piperidinyl)-imidazo(2,1-b)quinazolin-2(3H)-one; denbufylline; manoalide; tricyclodecane-9-yl-xanthogenate
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
GEBR-7b  0   *Imines *Morpholines Phosphodiesterase Inhibitors Cyclic Nucleotide Phosphodiesterases, Type 4. Br J Pharmacol. 2011 Dec;164(8):2054-63.
hesperetin-7,3'-O-dimethylether  0   Hesperidin/*analogs & derivatives Phosphodiesterase Inhibitors Cyclic Nucleotide Phosphodiesterases, Type 4. J Biomed Sci. 2011;18:84.
cipamfylline  0   *Xanthines Phosphodiesterase Inhibitors. Br J Pharmacol 2002 Aug;147(2):299-7
(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride  0   Sulindac/*analogs & derivatives Phosphodiesterase Inhibitors. J Pharmacol Exp Ther 2001 Nov;299(2):583-92
mesopram  0   *Oxazoles Phosphodiesterase Inhibitors Phosphoric Diester Hydrolases. J Neuroimmunol 2000 Aug 1;108(1-2):136-46
E 4010  0   *Nitriles *Piperidines Phosphodiesterase Inhibitors. J Pharmacol Exp Ther 1999 Aug;290(2):748-52
BBB022A  0   Organic Chemicals Blood-Brain Barrier Phosphodiesterase Inhibitors. J Neuroimmunol 1999 Jun 1;97(1-2):119-28
PLI-B protein, Trimeresurus flavoviridis  0   *Glycoproteins Phosphodiesterase Inhibitors. Gene 1997 May 20;191(1):31-7
PLI-A protein, Trimeresurus flavoviridis  0   *Glycoproteins Phosphodiesterase Inhibitors. Gene 1997 May 20;191(1):31-7
GW 3600  0   *Pyrrolidines Phosphodiesterase Inhibitors. J Med Chem 1995 Dec 22;38(26):4972-5
ICI 145730  0   Organic Chemicals Phosphodiesterase Inhibitors. Biochem Soc Trans 1990;18(3):473
Ro 20-7222  64734-75-4   Organic Chemicals Phosphodiesterase Inhibitors. J Exp Cell Res 95(2):351;1975; J Neurobiol 8(4):371;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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