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Phosphogluconate Dehydrogenase

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Definition: An enzyme of the oxidoreductase class that catalyzes the reaction 6-phospho-D-gluconate and NADP+ to yield D-ribulose 5-phosphate, carbon dioxide, and NADPH. The reaction is a step in the pentose phosphate pathway of glucose metabolism. (From Dorland, 27th ed) EC 1.1.1.43.      Other names Dehydrogenase, Phosphogluconate; Dehydrogenase, 6-Phosphogluconate; 6 Phosphogluconate Dehydrogenase; 6-Phosphogluconate Dehydrogenase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ethylenesulfonic acid  1184-84-5   *Ethylenes *Sulfonic Acids Phosphogluconate Dehydrogenase/antagonists & inhibitors. Mycopathologia 1993 Sep;123(3):155-8
phosphogluconate dehydrogenase (decarboxylating)  EC 1.1.1.44   *Phosphogluconate Dehydrogenase. Biochim Biophys Acta 1981;657(1):232
lyapolate  26101-52-0   *Polyvinyls *Sulfonic Acids Phosphogluconate Dehydrogenase/antagonists & inhibitors. J Exp Zool 186(2):175;1973; J Virol 16(5):1146;1975

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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