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Type C Phospholipases

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Definition: A subclass of phospholipases that hydrolyze the phosphoester bond found in the third position of GLYCEROPHOSPHOLIPIDS. Although the singular term phospholipase C specifically refers to an enzyme that catalyzes the hydrolysis of PHOSPHATIDYLCHOLINE (EC 3.1.4.3), it is commonly used in the literature to refer to broad variety of enzymes that specifically catalyze the hydrolysis of PHOSPHATIDYLINOSITOLS.  general; many specifics are available   
Examples Glycosylphosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C 		Other names Phospholipases, Type C; Phospholipase C; Lecithinase C; Phospholipases C
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Plc1 protein, S cerevisiae  EC 3.1.4.3   *Type C Phospholipases *Saccharomyces cerevisiae Proteins. Mol Biol Cell 2007 Jul;18(7):2419-28
plcb3 protein, zebrafish  EC 3.1.4.11   *Type C Phospholipases *Zebrafish Proteins. Dev Biol 2007 Apr 1;304(1):194-207
NPC4 protein, Arabidopsis  EC 3.1.4.3   *Type C Phospholipases *Arabidopsis Proteins. J Biol Chem 2005 Mar 4;280(9):7469-76
3-nitrocoumarin  0   *Coumarins *Nitro Compounds Type C Phospholipases/antagonists & inhibitors. Cell Biochem Funct 2001 Dec;19(4):229-35
phospholipase C1  EC 3.1.4.-   *Type C Phospholipases. Plant Cell 2001 May;13(5):1143-54
ISC1 protein, S cerevisiae  EC 3.1.4.-   *Type C Phospholipases *Saccharomyces cerevisiae Proteins. J Biol Chem 2000 Dec 15;275(50):39793-8
uncarinic acid A  0   Oleanolic Acid/*analogs & derivatives Type C Phospholipases/antagonists & inhibitors Uncaria. Bioorg Med Chem Lett 1999 May 17;9(10):1429-32
myristoylated-GLFRKAMRLRFPV  0   *Oligopeptides Type C Phospholipases/antagonists & inhibitors. J Biochem (Tokyo) 1997 Oct;122(4):738-42
myristoylated-GLYRKAMRLRYPV  0   *Oligopeptides Type C Phospholipases/antagonists & inhibitors. J Biochem (Tokyo) 1997 Oct;122(4):738-42
phosphatidylcholine-specific phospholipase C  EC 3.1.4.3   *Type C Phospholipases Metalloproteins Phosphatidylcholines. J Biol Chem 1997 Apr 25;272(17):11011-6
deacetylcaloporoside  0   *Salicylic Acids Mannose/*analogs & derivatives Type C Phospholipases/antagonists & inhibitors. J Antibiot (Tokyo) 1996 Jul;49(7):713-5
MpcB protein, Mycobacterium tuberculosis  EC 3.1.4.3   *Bacterial Proteins *Type C Phospholipases. Infect Immun 1996 Aug;64(8):3259-66
MpcA protein, Mycobacterium tuberculosis  EC 3.1.4.3   *Bacterial Proteins *Type C Phospholipases. Infect Immun 1996 Aug;64(8):3259-66
VP 616L  0   *Phosphonic Acids Inositol/*analogs & derivatives Type C Phospholipases/antagonists & inhibitors. J Biol Chem 1996 Jun 28;271(26):15468-77
Ppp1r14b protein, mouse  0   *Proteins Type C Phospholipases. Biochem Biophys Res Commun 1996 Jun 14;223(2):335-40
caloporoside  160471-36-3 D-Mannonic acid, 5-O-(2-O-acetyl-beta-D-mannopyranosyl)-, 16-(2-carboxy-3-hydroxyphenyl)-1-methylhexadecyl ester, 2-acetate, (R)  *Salicylic Acids Mannose/*analogs & derivatives Type C Phospholipases/antagonists & inhibitors. J Antibiot (Tokyo) 1994 Nov;47(11):1188-94
hispidospermidin  0   Spermidine/*analogs & derivatives Type C Phospholipases/antagonists & inhibitors. J Antibiot (Tokyo) 1994 Jan;47(1):6-15
U 73343  142878-12-4   *Estrenes *Pyrrolidinones Type C Phospholipases/antagonists & inhibitors. Endocrinology 1992 Jun;130(6):3475-83
1-S-phosphocholine-2-O-hexadecanoyl-1-mercapto-2-ethanol  73130-93-5   *Fatty Acids *Phosphorylcholine Type C Phospholipases/antagonists & inhibitors. Lipids 1991 Nov 26(11):957-9
demethoxyviridin  56660-21-0   *Androstenes Type C Phospholipases/antagonists & inhibitors Phospholipase D/antagonists & inhibitors Phospholipases A/antagonists & inhibitors. Br J Pharmacol 1991;103(1):1237
p47 (gag-crk) protein, Avian sarcoma virus  0   *Retroviridae Proteins *Oncogene Protein v-crk Type C Phospholipases. Cold Spring Harb Symp Quant Biol 1988;53(Pt 2):907
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione  112648-68-7 1H-Pyrrole-2,5-dione, 1-(6-(((17beta)-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)  *Estrenes *Pyrrolidinones Type C Phospholipases/antagonists & inhibitors.
Pharma Action Phosphodiesterase Inhibitors ; Platelet Aggregation Inhibitors 		Adv Prostaglandin Thromboxane Leukotriene Res 1989;19:590
tricyclodecane-9-yl-xanthogenate  83373-60-8   *Bridged Compounds *Thiones Type C Phospholipases/antagonists & inhibitors Sphingomyelin Phosphodiesterase/antagonists & inhibitors.
Pharma Action Antineoplastic Agents ; Antioxidants ; Antiviral Agents ; Phosphodiesterase Inhibitors 		J Gen Virol 1985;66(Pt 9):1953
alpha toxin, Clostridium perfringens  EC 3.1.4.3   *Bacterial Toxins *Calcium-Binding Proteins *Type C Phospholipases Metalloproteins. Arch Dis Child 1984;59(3):270
2-nitro-4-carboxyphenyl-N,N-diphenylcarbamate  10556-88-4 Benzoic acid, 4-(((diphenylamino)carbonyl)oxy)-3-nitro  *Phenylcarbamates Type C Phospholipases/antagonists & inhibitors.
Pharma Action Phosphodiesterase Inhibitors ; Protease Inhibitors 		Adv Prostaglandin Thromboxane Res 1980;6:321

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