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Phospholipase D

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Definition: An enzyme found mostly in plant tissue. It hydrolyzes glycerophosphatidates with the formation of a phosphatidic acid and a nitrogenous base such as choline. This enzyme also catalyzes transphosphatidylation reactions. EC 3.1.4.4.      Other names Lecithinase D; Phosphatidylcholine Phosphohydrolase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
mitoPLD protein, mouse  EC 3.1.4.4   *Phospholipase D *Mitochondrial Proteins. Dev Cell 2011 Mar 15;20(3):364-75
N-(2-(1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro(4.5)decan-8-yl)ethyl)-2-naphthamide  0   *Naphthalenes *Spiro Compounds Phospholipase D/antagonists & inhibitors. J Med Chem 2010 Sep 23;53(18):6706-19
5-fluoro-2-indolyldeschlorohalopemide  0   *Indoles Domperidone/*analogs & derivatives Phospholipase D/antagonists & inhibitors. Mol Pharmacol 2009 Mar;75(3):437-46
phospholipase D3, mouse  EC 3.1.4.4   *Phospholipase D. J Biol Chem 1998 Nov 20;273(47):31494-504
NAPE-PLD protein, rat  EC 3.1.4.4   *Phospholipase D. J Biol Chem 2004 Feb 13;279(7):5298-305
phospholipase Dzeta2, Arabidopsis  EC 3.1.4.4   *Phospholipase D *Arabidopsis Proteins. Plant Physiol 2006 Feb;140(2):761-70
N-acylphosphatidylethanolamine phospholipase D, mouse  EC 3.1.4.4   *Phospholipase D. Biochem J 2005 Jul 1;389(Pt 1):241-7
phospholipase Dzeta1, Arabidopsis  EC 3.1.4.4   *Phospholipase D *Arabidopsis Proteins. Science 2003 May 30;300(5624):1427-30
SPO14 protein, S cerevisiae  EC 3.1.4.4   *Phospholipase D *Saccharomyces cerevisiae Proteins. J Cell Biol 2002 Dec 23;159(6):1039-49
phospholipase D delta  EC 3.1.4.-   *Phospholipase D. Plant Physiol 2001 Nov;127(3):1102-12
Sch 420789  0   *Fatty Acids, Unsaturated *Naphthalenes Phospholipase D/antagonists & inhibitors. J Antibiot (Tokyo) 2000 Aug;53(8):837-8
phospholipase D1  EC 3.1.4.4   *Phospholipase D. Biochem Biophys Res Commun 1997 Jun 27;235(3):854-9
CT 2584  166981-13-1   *Xanthines Phospholipase D/antagonists & inhibitors. Free Radic Biol Med 1997;22(3):497-507
phospholipase D2  EC 3.1.4.-   *Phospholipase D. J Biol Chem 1997 Apr 25;272(17):11408-13
HAJ11  0   *Furans Phospholipase D/antagonists & inhibitors Protein-Tyrosine Kinases/antagonists & inhibitors. Br J Pharmacol 1997 Jan;120(1):79-87
synaptojanin  EC 3.1.3.-   *Nerve Tissue Proteins *Phosphoric Monoester Hydrolases Phospholipase D/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Nature 1996 Jan 25;379(6563):353-7
demethoxyviridin  56660-21-0   *Androstenes Type C Phospholipases/antagonists & inhibitors Phospholipase D/antagonists & inhibitors Phospholipases A/antagonists & inhibitors. Br J Pharmacol 1991;103(1):1237
glycoprotein phospholipase D  EC 3.1.4.50   *Phospholipase D. Eur J Biochem 1990;190(3):593

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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