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Phosphonoacetic Acid

More information in Books or onNLM PubMed
Definition: A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.     
Pharmacological Action Antiviral Agents; Enzyme Inhibitors; Reverse Transcriptase Inhibitors
Examples Foscarnet 		Other names Phosphonoacetate; Sodium, Fosfonet; Phosphonoacetate, Disodium; Acid, Phosphonoacetic; Acid, Phosphonacetic; Phosphonacetic Acid; Fosfonet Sodium; Disodium Phosphonoacetate
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
6-methacryloyloxyhexyl phosphonoacetate  0   *Methacrylates Phosphonoacetic Acid/*analogs & derivatives. Dent Mater J 2009 Sep;28(5):558-64
adenosine phosphonoacetic acid  0   Adenosine Diphosphate/*analogs & derivatives Phosphonoacetic Acid/*analogs & derivatives. Med Chem 2005 Nov;1(6):529-36
N-phosphonomethyliminodiacetic acid  0   Phosphonoacetic Acid/*analogs & derivatives. Can J Microbiol 1997 Jan;43(1):97-101
phosphonoacetohydroxamate  89873-30-3   *Hydroxamic Acids Phosphonoacetic Acid/*analogs & derivatives. Biochemistry 1994 May 24;33(20):6295-300
triethyl phosphonoacetate  867-13-0   Phosphonoacetic Acid/*analogs & derivatives. Int J Pept Protein Res Mar;39(3):273-7
2-bromophosphonoacetic acid  97730-55-7   Phosphonoacetic Acid/*analogs & derivatives. Am J Physiol 1990;258(4 Pt 1):C583
alpha-chloro-alpha-bromophosphonoacetic acid  111863-21-9   Phosphonoacetic Acid/*analogs & derivatives. Biochem Biophys Res Commun 1988;153(3):1152
ethyl diethyl-phosphonoformate  1474-78-8 diethyoxyphosphinecarboxylic acid, ethyl ester, oxide  Phosphonoacetic Acid/*analogs & derivatives. Virology 1980;102(1):226
preparation 1311  69152-47-2 4-Pyridinecarboxylic acid, 2-(phosphonoacetyl)hydrazide  Isoniazid/*analogs & derivatives Phosphonoacetic Acid/*analogs & derivatives. Probl Tubercl 11:79;1978
N-(phosphonoacetyl)putrescine  67023-07-8 Phosphonic acid, (2-((4-aminobutyl)amino)-2-oxoethyl)  Phosphonoacetic Acid/*analogs & derivatives Putrescine/*analogs & derivatives. FEBS Lett 88:94;1978
methylacetylphosphonate  40962-37-6   Phosphonoacetic Acid/*analogs & derivatives. J Am Chem Soc 99(13):4504;1977
NSC 224131  51321-79-0 N-(phosphonoacetyl)-L-aspartic acid  Aspartic Acid/*analogs & derivatives Phosphonoacetic Acid/*analogs & derivatives.
Pharma Action Antimetabolites, Antineoplastic ; Antiviral Agents ; Enzyme Inhibitors 		Arch Biochem Biophys 161:76;1974; Biochem Pharmacol 26:81;1977; Biochemistry 17(5):784;1978; Cancer 40(5)Suppl:2640;1977; Cancer Chemother Pharmacol 1979;3(3):135; Cancer Chemother Pharmacol 2(3):183;1979; Cancer Res 1979;39(10):3992; Cancer Res 1980;40(1):86; Cancer Res 36:2720;1976; Cancer Res 37(9):3080;1977; Cancer Res 38(11):3745;1978; Cancer Res 38:371;1978; Cancer Res 39(8):3089;1979; Cancer Trat Rep 1979;63(8):1291; Cancer Treat Rep 1979;63(11-12):1909; Cancer Treat Rep 62(10):1503;1978; Cancer Treat Rep 63(5):775;1979; Cancer Treat Rep 63(6):1095;1979; Cell 9(4):541;1976; Experientia 33(4):428;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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