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Phthalic Acids

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Definition: A group of compounds that has the general structure of a dicarboxylic acid-substituted benzene ring. The ortho-isomer is used in dye manufacture. (Dorland, 28th ed)     
Examples Dibutyl Phthalate; Diethylhexyl Phthalate; o-Phthalaldehyde; Phthalic Anhydrides; Phthalimides 		Other names Acids, Phthalic
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1,3-bis(4-isobutyramidobenzamido)-2,4-bis(3-methoxy-4-(thiophene-2-carbonyloxy)phenyl)cyclobutane-1,3-dicarboxylic acid  0   *Cyclobutanes *Phthalic Acids. J Med Chem. 2012 Jan 12;55(1):250-67.
bis(2-ethyltridecyl)phthalate  0   *Phthalic Acids. J Asian Nat Prod Res. 2012;14(1):22-6
bis(2-ethylundecyl)phthalate  0   *Phthalic Acids. J Asian Nat Prod Res. 2012;14(1):22-6
(2RS,3RS)-5-amino-3-(4-(3-methoxyphenyl)piperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-ol  0   *Phthalic Acids *Piperazines. Acta Crystallogr C. 2011 Nov;67(Pt 11):o469-72
poly(nonamethylene terephthalate)  0   *Phthalic Acids Polymers. Phys Chem Chem Phys. 2011 Oct 21;13(39):17841-51
3-(((3-carboxycyclohexyl)amino)carbonyl)-4-(3-(4-(4-phenoxybutoxy)phenyl)propoxy)benzoic acid  0   *Cyclohexanecarboxylic Acids *Phthalic Acids. J Pharmacol Exp Ther. 2011 Dec;339(3):768-78.
5-tert-butyl isophthalate  0   *Phthalic Acids. Dalton Trans. 2011 Oct 14;40(38):9731-6
VEA 260  0   *Hydrazines *Phthalic Acids. Chem Biol 2011 Jun 24;18(6):711-21
JCP 666  0   *Hydrazines *Phthalic Acids. Chem Biol 2011 Jun 24;18(6):711-21
3,4,5,6-tetrachloro-N-(methyl-2-pyridyl)phthalmic acid  0   *Phthalic Acids *Pyridines. Acta Crystallogr C. 2011 Jul;67(Pt 7):o255-8
o-(pentafluorobenzyloxycarbonyl)-2,3,4,5-tetrafluorobenzoyl chloride  0   *Phthalic Acids. Anal Bioanal Chem 2011 Jun;400(8):2623-30
methylterephthalamide  0   *Amides *Phthalic Acids Ligands. Chem Commun (Camb). 2011 Jun 14;47(22):6392-4
di-(2-ethylhexyl)phthalate  0   *Phthalic Acids. Nat Prod Res. 2011 Apr;25(8):806-14
XL 888  0   *Phthalic Acids *Azabicyclo Compounds HSP90 Heat-Shock Proteins/antagonists & inhibitors. PLoS One 2011;6(3):e17692
butyl isobutyl phthalate  0   *Phthalic Acids alpha-Glucosidases/antagonists & inhibitors. J Biochem 2011 Jan;149(1):27-33
GRL 8234  0   *Phthalic Acids *Sulfonamides Amyloid Precursor Protein Secretases/antagonists & inhibitors. FASEB J 2011 Feb;25(2):775-84
2-bromo-5-tert-butylisophthalic acid  0   *Phthalic Acids. Chemistry. 2010 Sep 10;16(34):10576-91
poly(2,5-bis((6-(4-butoxy-4'-oxybiphenyl)hexyl)oxycarbonyl)styrene)  0   *Phthalic Acids *Polystyrenes. J Am Chem Soc 2010 Jun 16;132(23):8071-80
2-(2-carboxybenzoylamino)-4-(3'-chloro-4'-fluorobiphenyl-4-yl)thiophene-3-carboxylic acid ethyl ester  0   *Phthalic Acids *Thiophenes Protein Tyrosine Phosphatase, Non-Receptor Type 1/antagonists & inhibitors. Bioorg Med Chem 2010 Mar 1;18(5):1773-82
3-(((3-carboxycyclohexyl)amino)carbonyl)-4-(3-(4-(4-(cyclohexyloxy)butoxy)phenyl)propoxy)benzoic acid  0   *Cyclohexanecarboxylic Acids *Phthalic Acids. Br J Pharmacol 2010 May;160(2):399-409
5-sulfoisophthalic acid  0   *Phthalic Acids. Biotechnol Lett. 2010 Mar;32(3):445-50
beta-phthaliminoacrylate ester  0   *Acrylates *Phthalic Acids. J Am Chem Soc. 2010 Jan 20;132(2):464-5
1,4-benzenedicarboxylate  0   *Phthalic Acids. Science. 2010 Feb 12;327(5967):846-50
XVA 143  0   *Phthalic Acids beta-Alanine/*analogs & derivatives. Antimicrob Agents Chemother 2009 Nov;53(11):4656-66
bis(benzoyloxyethyl)terephthalate  0   *Benzoates *Phthalic Acids. J Biochem Biophys Methods 2006 Nov 30;69(1-2):207-12
disila-tamibarotene  0   *Phthalic Acids *Organosilicon Compounds. ChemMedChem 2009 Nov;4(11):1797-802
4-sulfophthalic acid 1,2-(di-2-ethylhexyl) ester  0   *Phthalic Acids *Sulfonic Acids. Spectrochim Acta A Mol Biomol Spectrosc 2009 Sep 15;74(1):174-9
4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic acid hexahydrate  0   *Hydrocarbons, Fluorinated *Phthalic Acids. Acta Crystallogr C. 2009 Jun;65(Pt 6):o287-9
5-amino-2,4,6-tribromoisophthalic acid  0   *Phthalic Acids. Acta Crystallogr C. 2009 May;65(Pt 5):o237-9
N1-(2-aminophenyl)-N4-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)terephthalamide  0   *Phthalic Acids *Pyrimidines Histone Deacetylases/antagonists & inhibitors Protein-Tyrosine Kinases/antagonists & inhibitors. J Med Chem 2009 Apr 23;52(8):2265-79
2,3,5,6-tetramethyl-1,4-benzenedicarboxylic acid  0   *Phthalic Acids. Dalton Trans 2009 Feb 7;(5):763-6
tyrammonium 4-nitrophthalate dihydrate  0   *Phthalic Acids Tyrosine/*analogs & derivatives. Amino Acids. 2009 Jan;36(1):29-33
dextran methacylate phthalate  0   *Dextrans *Methacrylates Phthalic Acids. J Drug Target 2008 Nov;16(9):649-59
melaminium phthalate  0   *Phthalic Acids *Triazines. Spectrochim Acta A Mol Biomol Spectrosc. 2008 Nov 1;71(1):169-74
5-(4-methylthio-2-phthalimidylbutanoylamino)isophthalic acid  0   *Phthalic Acids. Amino Acids. 2008 May;34(4):531-8
N'-morpholino-N-(2'-methoxyphenyl)phthalamide  0   *Morpholines *Phthalic Acids. J Org Chem 2008 May 16;73(10):3730-7
benzamido-N,N-bis(cyclopentyl)carboxamide  0   *Phthalic Acids. Acta Pol Pharm 2007 Jul-Aug;64(4):365-8
benzamido-N-prop-2-ynyl-N-cyclopentylcarboxamide  0   *Phthalic Acids. Acta Pol Pharm 2007 Jul-Aug;64(4):365-8
N(4)-(2-(diethylamino)ethyl)-2-iodo-N(1)-(4-methyl-1-(4-methyl-1-(4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-yl)terephthalamide  0   *Oligopeptides *Phthalic Acids Iodine Radioisotopes. J Med Chem 2008 Feb 28;51(4):1043-7
terephthalic acid isopropylamide  0   *Phthalic Acids. J Clin Lab Anal 2008;22(1):21-8
4,5-dichlorophthalic acid  0   *Phthalic Acids. Acta Crystallogr C 2008 Mar;64(Pt 3):o180-3
3-nitroisophthalic acid  0   *Phthalic Acids. Acta Crystallogr C 2008 Mar;64(Pt 3):o123-7
4-nitroisophthalic acid  0   *Phthalic Acids. Acta Crystallogr C 2008 Mar;64(Pt 3):o123-7
5-nitroisophthalic acid  0   *Phthalic Acids. Acta Crystallogr C 2008 Mar;64(Pt 3):o123-7
cyclo-tris-ethylene terephthalate  0   *Phthalic Acids. Biotechnol Prog 2006 Jul-Aug;22(4):1209-14
hexyl methyl phthalate  0   *Phthalic Acids. J Appl Microbiol 2007 Jan;102(1):221-8
(2.2)(1,4)phthalocyaninophane  0   *Nitriles *Phthalic Acids. J Am Chem Soc 2007 Apr 18;129(15):4516-7
diisopropylammonium 2-((2,4-dinitrophenyl)sulfanylaminocarbonyl)benzoate  0   *Phthalic Acids. Acta Crystallogr C 2007 Jan;63(Pt 1):o48-50
N-(1-(3,5-difluorobenzyl)-2-hydroxy-3-(3-iodobenzylamino)propyl)-5-methyl-N',N'-dipropylisophthalamide  0   *Phthalic Acids Amyloid Precursor Protein Secretases/antagonists & inhibitors. J Med Chem 2007 Feb 22;50(4):776-81
monomethyl phthalate  0   *Phthalic Acids. Spectrochim Acta A Mol Biomol Spectrosc. 2006 Nov;65(3-4):689-94
2-methoxyisophthalamide  0   *Amides *Phthalic Acids. J Org Chem. 2006 Nov 24;71(24):9035-44
WK-X-50  0   *Phthalic Acids *Quinolines. Cancer Chemother Pharmacol 2007 Jan;59(1):61-9
XR 9577  0   *Phthalic Acids *Quinolines. Cancer Chemother Pharmacol 2007 Jan;59(1):61-9
barbatic acid  0   *Phthalic Acids. Biosci Biotechnol Biochem. 2006 Jan;70(1):266-8
poly(L-lysine iso-phthalamide)  0   *Phthalic Acids *Polylysine *Polymers. J Control Release 2005 Nov 2;108(1):63-72
3-aminophthalate  0   *Phthalic Acids. J Agric Food Chem. 2005 Nov 2;53(22):8443-6
N(1)-((diethylamino)ethyl)-N(4)-(4-methyl-1-(4-methyl-1-(4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-yl)terephthalamide  0   *Oligopeptides *Phthalic Acids. J Med Chem 2005 Oct 20;48(21):6731-40
5-octadecyloxyisophthalic acid  0   *Phthalic Acids. J Am Chem Soc. 2005 Sep 21;127(37):12750-1
(N-N'-bis-(2-(1H-indol-3-yl)-ethyl)-N,N'-bis-(3-thiomorpholin-4-yl-propyl)-phthalamide)  0   *Indoles *Morpholines *Phthalic Acids. Eur J Pharmacol. 2005 Jun 1;516(2):104-111
poly(m-phenyleneisophthalamide)  0   *Amides *Phthalic Acids Polymers. Anal Chem. 2005 Feb 1;77(3):780-4
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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